Gene regulatory network determinants of rapid recall in human memory CD4+ T cells [0.03%]
人记忆CD4+T细胞中快速回忆的基因调控网络决定因素
Alexander Katko,Svetlana Korinfskaya,Anthony T Bejjani et al.
Alexander Katko et al.
Rapid recall is the hallmark of memory T cells. While naive cells require days to mount effector responses to new threats, antigen-experienced memory cells produce cytokines within hours of a repeat encounter. Compared to naive cells, memor...
The effector differentiation of TCRαβ+CD8αα+ intraepithelial lymphocytes is reciprocally regulated by BCL6 and BLIMP1 [0.03%]
BCL6和BLIMP1反向调节TCRαβCD8αalpha+上皮内淋巴细胞效应分化
Qi Xing,Shiyuan Xie,Jiaqi Ma et al.
Qi Xing et al.
CD8αα+TCRαβ+ intraepithelial lymphocytes (IELs) play crucial roles in maintaining intestinal homeostasis and host protection. However, the functional regulation of these cells remains unclear. Here, we have discovered and characterized ...
Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis [0.03%]
MLKL的自抑制调控在坏死性凋亡过程中调控假激酶域磷酸化和寡聚化
Michelle J Pan,Derek W Abbott
Michelle J Pan
Necroptotic cell death triggers the release of inflammatory mediators but the exact mechanisms controlling its activation are not fully understood. Previous studies have identified key steps during necroptosis, which are believed to be coup...
IL-4 triggers salivary duct dilatation via SHH signaling and exacerbates Sjögren's disease [0.03%]
IL-4通过SHH信号通路引发唾液腺导管扩张并加重舍格伦综合征病情
Jingyi Zhang,Jing Zhang,Yanrong Zhao et al.
Jingyi Zhang et al.
Primary Sjögren's disease (pSjD) is a chronic autoimmune disease. Clinically, sialography and lip gland biopsy in patients with pSjD show characteristic ductal dilations. However, the roles of the immune responses in ductal dilation remain...
Ying Zhao,Qin Wei,Rui Zeng et al.
Ying Zhao et al.
Keloids are pathological scars caused by dysregulated wound healing, characterized by fibroblast hyperproliferation and excessive extracellular matrix deposition. Natural killer (NK) cells restrain aberrant cell growth through IFN-γ but al...
Time of day alters olfactory bulb immune state with ramifications for intranasal inflammatory challenge [0.03%]
时间影响嗅球免疫状态并影响鼻内炎症损伤
Gregory L Pearson,Brennan A Baca,Jiexin Wang et al.
Gregory L Pearson et al.
The circadian and immune systems are important for tissue homeostasis, yet their integration in the brain remains understudied. The olfactory bulb, a brain region that exhibits robust circadian rhythms and is regularly exposed to inflammato...
Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages [0.03%]
吞噬性垫状体使初级人单核细胞衍生的巨噬细胞能够有效摄取白色念珠菌auris strains
Konstantin Sopelniak,Rawan Batlouni,Qifan Sun et al.
Konstantin Sopelniak et al.
The yeast Candida auris is an emerging pathogen. Understanding the molecular mechanisms of its uptake and processing by immune cells is thus critical for counteracting the spread of respective infections. We show that the phagocytosis of C....
Phytochrome B modulates high-temperature-induced flowering in soybean by promoting degradation of PSEUDO-RESPONSE REGULATOR 5 proteins [0.03%]
PHYTOCHROME B通过促进PSEUDO-RESPONSE REGULATOR 5蛋白降解调控大豆高温诱导开花反应
Zhihong Hou,Haiyang Li,Yang Tang et al.
Zhihong Hou et al.
High ambient temperature accelerates soybean (Glycine max) flowering to escape stress and accomplish reproduction, but the underlying molecular mechanism remains unclear. Here, we report that phytochrome B1 (phyB1) and phyB2 and the core ci...
Subversion of kynurenine-induced AHR activation in CD8 T cells by kynureninase-expressing antigen-presenting cells [0.03%]
表达犬尿酸酶的抗原呈递细胞通过降解犬尿酸削弱CD8+T细胞中的AhR活化
Michael A Giacomantonio,Vishnu Vijay Vijayan,Preethi G Nair et al.
Michael A Giacomantonio et al.
Kynurenine, an intermediate metabolite of tryptophan metabolism, suppresses the antitumor activity of CD8+ T cells by activating the aryl hydrocarbon receptor (AHR). Its role in adaptive immunity is poorly understood. Outside the liver, kyn...
Identification and characterization of BRAF⇔TP53 interactions in melanoma [0.03%]
黑色素瘤中BRAF与TP53相互作用的鉴定及特征分析
Kayla T O&#x;Toole,Adamaris Martinez,Brandon Murphy et al.
Kayla T O&#x;Toole et al.
Activating mutations in BRAF are common in cutaneous melanoma, yet mutational inactivation of the tumor suppressor TP53 is relatively rare despite widespread attenuation of TP53 function, suggesting alternate mechanisms of TP53 inhibition. ...