The nBAF complex subunit CREST/SS18L1 regulates hippocampal memory processes via tyrosine 397 and histone acetyltransferase CBP [0.03%]
nBAF复合体亚基CREST/SS18L1通过酪氨酸397和组蛋白乙酰转移酶CBP调节海马记忆过程
Franklin G Garcia,Maria Farias de Albuquerque,Vanessa Johnson et al.
Franklin G Garcia et al.
Chromatin-modifying and -remodeling machineries are important for learning-induced transcriptional activity, yet it remains unclear how they coordinate to drive de novo gene expression for memory formation. Here, we examine the transcriptio...
Antibacterial microcins self-assemble to promote biofilm formation in Acinetobacter baumannii [0.03%]
微环肽抗生素通过促进鲍曼不动杆菌生物被膜形成而自组装
Mady S Telford,Michelle Mikesh,Jennifer K Parker et al.
Mady S Telford et al.
The bacterial pathogen Acinetobacter baumannii forms a resilient biofilm, enhancing bacterial survival in hostile environments. Although biofilm structure is primarily built from polysaccharides and nucleic acids, specific proteins are ofte...
Akirin regulates the cell development and symbiont abundance of bacteriocytes in embryos of whitefly Bemisia tabaci [0.03%]
白飞虱Bemisia tabaci胚胎中植内细胞发育和胞内共生菌丰度受Akirin调控
Shan Jiang,Na-Na Li,Ji-Sheng Hong et al.
Shan Jiang et al.
Insects have specialized host cells, namely bacteriocytes, to house intracellular symbionts. However, knowledge of the mechanisms underlying regulation of bacteriocyte development and associated symbiont abundance during insect embryogenesi...
Astrocytic AEBP1-NPAS3-LIPA pathway coordinates cholesterol homeostasis to regulate Alzheimer's pathology [0.03%]
星形胶质细胞胆固醇稳态轴控制阿尔茨海默病病理变化
Jialin Wu,Xiaonan Lu,Jienian Zhang et al.
Jialin Wu et al.
Astrocytes regulate brain cholesterol homeostasis, but the astrocyte-specific mechanisms disrupted in Alzheimer's disease (AD) are poorly understood. By integrating human bulk transcriptomes with single-nucleus RNA sequencing (RNA-seq), we ...
SETDB2-mediated transcriptional repression of IDE in sensory neurons promotes migraine-like pain behaviors in mice [0.03%]
小鼠感觉神经元中SETDB2介导的IDE转录抑制促进偏头痛样疼痛行为
Yunmei Zhang,Zitong Huang,Yufang Sun et al.
Yunmei Zhang et al.
The persistent headaches characteristic of chronic migraine may stem from the activation and sensitization of primary afferent neurons within the trigeminovascular pathway. However, the underlying molecular mechanisms remain unclear. This s...
CDK1-dependent N-terminal NuMA phosphorylation promotes dynein-dynactin-NuMA assembly for accurate chromosome segregation [0.03%]
CDK1介导的NuMA N端磷酸化促进动力蛋白-动力臂-NuMA组装以保证染色体精确分离
Marvin van Toorn,Merve Aslan,Keishi Shintomi et al.
Marvin van Toorn et al.
The microtubule-based motor dynein and its cofactor dynactin are activated by various adaptors to fulfill essential functions throughout the cell cycle, including organelle transport and mitotic spindle assembly. NuMA is a mitotic adaptor t...
Jonathan E Henninger
Jonathan E Henninger
Acetylation of histones and transcriptional regulators modulates gene expression, but how acetyltransferases define target specificity remains puzzling. In Cell Reports, Gelder et al.1 have shown how intrinsically disordered regions of CBP ...
Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes [0.03%]
来自胰腺和局部引流淋巴结组织的空间转录组学揭示了1型糖尿病的淋巴毒素-β谱型
Miguel A Medina-Serpas,Maigan Brusko,Gregory J Golden et al.
Miguel A Medina-Serpas et al.
This study explores the inflammatory response observed in the pancreas and pancreatic lymph nodes (pLNs) during the natural history of type 1 diabetes (T1D). Using multicell-resolution spatial transcriptomics (ST), we profile individuals wi...
Endocannabinoid modulation of a reciprocal fronto-coerulear connection in contextual discrimination [0.03%]
内源大麻素在情境辨别中的前脑室核-蓝斑核环路的作用
Andrea Locarno,Luca Nava,Noemi Barsotti et al.
Andrea Locarno et al.
The prefrontal cortex (PFC) and locus coeruleus (LC) form a bidirectional circuit essential for cognitive control and arousal. LC-derived norepinephrine (NE) influences PFC network dynamics, yet the mechanisms by which descending PFC inputs...
Prefrontal cortex encodes behavior states decoupled from motor execution [0.03%]
解离于运动执行的行为状态编码：前额叶皮层的作用
Ida Välikangas Rautio,Fredrik Nevjen,Ingeborg Hem et al.
Ida Välikangas Rautio et al.
Prefrontal cortex is often viewed as an extension of the motor system, but little is understood about how it relates to natural motor behavior. We therefore tracked the kinematics of freely moving rats performing minimally structured tasks ...