Distinct endogenous retroviruses are expressed in mutational subtypes of clear cell renal cell carcinoma and are linked to improved clinical outcomes [0.03%]
不同内源性逆转录病毒在透明细胞肾细胞癌突变亚型中的表达及其与良好临床结果的关系
Kevin Meli,Cora A Ricker,Sabrina Y Camp et al.
Kevin Meli et al.
Distinct mutations in chromatin regulators and aberrant expression of transposable elements (TEs), have been associated with clinical benefit to immunotherapy (IO) in specific clear cell renal cell carcinoma (ccRCC) clinical contexts. Howev...
Yan Wang,Yanping Hu,Zhenhang Chen et al.
Yan Wang et al.
SARS-CoV-2 BA.3.2 sublineages, derived from BA.3 and carrying substantial spike divergence, raised concerns about altered fitness and antigenicity. Using BA.3.2.1 as a representative strain, we engineered live-attenuated SARS-CoV-2 encoding...
ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation [0.03%]
Alix通过控制EGFR活性和PD-L1呈递来调节肿瘤介导的免疫抑制
James Monypenny,Hanna Milewicz,Fabian Flores-Borja et al.
James Monypenny et al.
Published Erratum
Cell reports. 2026 Aug 8;45(8):117882. DOI:10.1016/j.celrep.2026.117882 2026
Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer's disease [0.03%]
基于人诱导多能干细胞的阿尔茨海默病模型中，小胶质细胞APOE3Christchurch保护神经元免受tau病理损害
Guoqiang George Sun,Cheng Wang,Randall C Mazzarino et al.
Guoqiang George Sun et al.
Published Erratum
Cell reports. 2026 Aug 8;45(8):117853. DOI:10.1016/j.celrep.2026.117853 2026
Integrative single-cell eQTL and GWAS analyses identify cell-type-specific regulatory mechanisms underlying ESCC susceptibility [0.03%]
整合单细胞eQTL和GWAS分析识别与食管癌易感性相关的特定细胞类型的调控机制
Lina Song,Miaoxin Pan,Yueping Li et al.
Lina Song et al.
Interpreting genetic risk variants within their relevant cellular contexts remains a central challenge in esophageal squamous cell carcinoma (ESCC), a malignancy with a substantial inherited component. We integrate single-cell RNA sequencin...
Depletion of CARM1 slows in vivo tumorigenicity and rewires developmental programming in glioma stem-like cells [0.03%]
CARM1耗竭抑制胶质瘤干细胞的体内成瘤并重编程其发育分化方向
Dejauwne L Young,Stephanie Stransky,Maria G Molero et al.
Dejauwne L Young et al.
Glioma stem-like cells (GSCs) exploit developmental signaling programs that contribute to glioblastoma heterogeneity and therapy resistance. Here, we define a role for the arginine methyltransferase coactivator-associated arginine methyltra...
Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism [0.03%]
乙酰辅酶A合成酶3（ACCS3）的昼夜调节控制肝脏线粒体赖氨酸-丙二酸化的昼夜节律及每日肝代谢
Enora Le Questel,Charlène Besnard,Florian Atger et al.
Enora Le Questel et al.
Hepatic daily rhythms are coordinated by feeding and the molecular circadian clock, ensuring metabolic homeostasis. Disrupted feeding schedules promote circadian misalignment and metabolic diseases but the underlying mechanisms remain scarc...
IL-19+ monocytes suppress neuroinflammation and promote neurological recovery in young individuals with traumatic brain injury [0.03%]
IL-19+单核细胞通过抑制神经炎症促进年轻创伤性脑损伤患者的神经功能恢复
Zhichao Lu,Jingwei Zhao,Jue Zhu et al.
Zhichao Lu et al.
Young patients with traumatic brain injury (TBI) have a better prognosis than the aged, but the underlying mechanisms are not clear. Here, we identified a population of IL-19+ monocytes derived from cranial bone marrow appearing in the brai...
APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice [0.03%]
人源性APOE3和APOE4星形胶质细胞在嵌合小鼠中对阿尔茨海默病病理变化和小胶质细胞反应的不同调节作用
Joan Cruz-Sese,Marta Mirón-Alcala,María Alfonso-Triguero et al.
Joan Cruz-Sese et al.
Astrocytes and APOE are strongly implicated in Alzheimer's disease (AD), yet the impact of astrocytes carrying different APOE variants on AD hallmarks remains incompletely understood. Here, we generate a chimeric model of AD by transplantin...
Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC [0.03%]
整合的三维基因组和表观基因组分析确定TP53RK和SYBU在HCC中是维持干细胞特性和抗肿瘤免疫的关键调节因子
Yanmei Yang,Peixian Li,Liangbo Zhao et al.
Yanmei Yang et al.
Three-dimensional (3D) genome organization plays a fundamental role in governing gene regulation and tumor cell properties. However, how higher-order chromatin architecture regulates stemness in hepatocellular carcinoma (HCC) remains unclea...