Cortical prostaglandin D2 contributes to behavioral sensitization and anxiety in peripheral inflammation [0.03%]
外周炎症诱导的行为异常与皮层前列腺素D2有关
Shuji Shimoyama,Tatsuya Ishikawa,Yoshihiko Oke et al.
Shuji Shimoyama et al.
Post-injury inflammation can induce abnormal sensory perception and negative emotions. Previous studies have focused on peripheral and spinal prostaglandins (PGs) in response to chronic pain. Substantially, less is known about the role of P...
PLA2G12A-driven extracellular vesicle-lipid signaling amplifies pathogenic T cell responses in inflammatory diseases [0.03%]
PLA2G12A驱动的细胞外囊泡-脂质信号放大炎症性疾病中的致病性T细胞反应
Chika Mochizuki-Ono,Yoshitaka Taketomi,Atsushi Irie et al.
Chika Mochizuki-Ono et al.
Extracellular vesicles (EVs) contribute to intercellular communication, yet how EV-driven lipid signaling is regulated in immune responses remains incompletely understood. Here, we show that genetic deficiency or antibody-mediated neutraliz...
DCAF8 binds DDB1 via an N-terminal helix-loop-helix motif to assemble CRL4 and promote cell cycle progression [0.03%]
DCAF8通过N端螺旋-环-螺旋基序结合DDB1以组装CRL4并促进细胞周期进程
Miaomiao Shen,Hang Zhang,Min Chen et al.
Miaomiao Shen et al.
Cullin-RING ligase 4 (CRL4) complexes achieve substrate specificity through DDB1-CUL4-associated factors (DCAFs), yet how individual DCAFs engage the adaptor protein DDB1 remains incompletely understood. Here, we report the cryo-electron mi...
NAT10-dependent N4-acetylcytidine reprograms R-loops and promotes cancer stem cell growth [0.03%]
NAT10依赖的N4-乙酰胞苷重新编程R-环并促进癌症干细胞生长
Xujia Wu,Donghai Wang,Suchet Taori et al.
Xujia Wu et al.
R-loop remodeling dynamically regulates chromatin states and gene expression; however, its exploitation by cancer to sustain self-renewal and malignancy remains poorly understood. Here, we find that glioblastoma (GBM) stem cells (GSCs) disp...
A spatial in situ hybridization approach to T cell clonotype analysis using T cell receptor variable gene probes [0.03%]
采用TCR可变基因探针进行T细胞克隆型分析的在体空间杂交方法研究
Cedric Ly,Darius P Schaub,Robin Khatri et al.
Cedric Ly et al.
Resolving T cell clonality at single-cell spatial resolution remains a major challenge. Here, we developed an in situ hybridization panel comprising probes for immune and tissue cell types alongside comprehensive coverage of TRAV, TRBV, TRG...
Characterization of a transmembrane-activating STING agonist using genetically humanized mice [0.03%]
利用转基因人源化小鼠表征跨膜活化的STING激动剂
Nobuyo Mizuno,Jinu Abraham,Kevin Jimenez-Perez et al.
Nobuyo Mizuno et al.
Stimulator of interferon genes (STING) is a pattern recognition receptor that activates type I interferon and proinflammatory responses following cytosolic DNA exposure. Its pharmacologic stimulation enhances vaccine potency and generates a...
Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery, and analyses in mouse pituitary gland research [0.03%]
小鼠垂体腺研究中的共识脑垂体图谱资源及其在注释、新标记物发现和分析中的应用
Bence Kövér,Thea L Willis,Olivia Sherwin et al.
Bence Kövér et al.
Previous single-cell profiling studies of the pituitary gland have yielded minimally reproducible insights due to their low statistical power and methodological inconsistencies. To address this, we generate the uniformly pre-processed Conse...
SIRT5-mediated FDX1 desuccinylation confers cuproptosis resistance in lung adenocarcinoma [0.03%]
SIRT5介导的FDX1脱琥珀酰化作用赋予肺腺癌铜死亡抵抗性
Qifan Hu,Zuorui Wang,Wenxin Deng et al.
Qifan Hu et al.
Cuproptosis, a copper-dependent cell death process induced by excessive copper, represents an emerging therapeutic strategy in oncology. However, tumor-specific molecular pathways regulating this process remain poorly defined. Here, we demo...
Activity-regulated circSamm50 modulates mitochondrial dynamics and spine structural plasticity [0.03%]
活动调节的circSamm50通过调控线粒体动态及突触结构可塑性来影响神经元功能
Kaushik Chanda,Ojasee Bapat,Jenna Lynne Wingfield et al.
Kaushik Chanda et al.
Circular RNAs (circRNAs) are highly enriched in the brain, yet their functional contributions to synaptic plasticity remain unclear. Here, we uncover a plasticity-induced circRNA that links mitochondrial regulation to activity-dependent spi...
Model-based and model-free valuation signals in the human brain vary markedly in relation to individual differences in behavioral control [0.03%]
人脑基于模型和不基于模型的估值信号与个体行为控制差异的关系截然不同
Weilun Ding,Jeffrey Cockburn,Julia Pia Simon et al.
Weilun Ding et al.
Human action selection under reinforcement is believed to rely on two distinct strategies: model-free and model-based reinforcement learning. While behavior in sequential decision-making tasks often reflects a mixture of both, the neural ba...