nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability [0.03%]
NSP3-FXR共凝聚促进雅司病病毒复制并揭示雅司病病毒脆弱性靶点
Yifan Xie,Jie Cao,Xinya Yang et al.
Yifan Xie et al.
Alphaviruses are mosquito-borne RNA viruses that pose a significant threat to humans, with risks worsened by global warming. Non-structural protein 3 (nsP3) is critical for alphavirus infection, yet its precise roles remain poorly defined. ...
Zhijian Ji,Henry de Belly,Taruna Pandey et al.
Zhijian Ji et al.
Oxidative protein folding in the endoplasmic reticulum (ER) is essential for eukaryotic cells yet generates hydrogen peroxide (H2O2), a reactive oxygen species. The ER-transmembrane protein that supports ER proteostasis and guards the cytos...
LKB1 inactivation elicits an NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer [0.03%]
LKB1失活通过NNMT介导的甲基受体作用使肺癌依赖于PRMT5
Wen Mi,Xinyi Xia,Yun Xue et al.
Wen Mi et al.
The protein arginine methyl transferase 5 (PRMT5) emerges as a therapeutic target in S-methyl-5'-thioadenosine phosphorylase (MTAP)-deleted cancers, where 5'-methylthioadenosine (MTA) accumulation partially inhibits its activity. However, i...
Neutrophil-derived itaconate facilitates tiered pulmonary inflammation via Kdm5b-associated epigenetic remodeling in alveolar macrophages [0.03%]
中性粒细胞衍生的衣康酸通过与肺泡巨噬细胞组蛋白去甲基化酶Kdm5b相关的表观遗传重编程促进分层的肺部炎症反应
Gyumin Lim,Juyeon Kim,Doyoung Park et al.
Gyumin Lim et al.
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), present a substantial clinical burden, magnified by conditions such as COVID-19. While these conditions provide a model for exploring complex inflammat...
CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity [0.03%]
CIDEB和CGI-58通过差异化调节肝脂滴胆固醇来调节代谢功能异常相关steatohepatitis的严重程度
Ikki Sakuma,Rafael C Gaspar,Henrique N Morgan et al.
Ikki Sakuma et al.
Metabolic dysfunction-associated steatohepatitis (MASH) increases liver-related mortality, and new therapies targeting its underlying mechanisms are warranted. We examined whether two lipid-droplet proteins, CIDEB and CGI-58, exert opposing...
Spatial and temporal single cell multi-omics in mice reveals macrophage-SFRP4+ stroma interactions promoting endometrial regeneration via TNF-α [0.03%]
小鼠空间和时间单细胞多组学揭示巨噬细胞通过TNF-α促进SFRP4+间质再生的相互作用
Yu Li,Huafei Zhao,Xuzhi Chen et al.
Yu Li et al.
Repair and regeneration disorder after endometrial injury is the core cause of endometrial diseases. Using a mouse full-thickness endometrial injury model and human endometrial datasets, we performed time-series single-cell and spatial omic...
Melanoma-patient-derived xenograft multi-omics resource melPDomiX maps gain- and loss-of-function alterations [0.03%]
黑色素瘤患者衍生异种移植多组学资源melPDomiX映射获得和失去功能的改变
Konstantinos Tsingas,Monzy Thomas,McKenna Reale et al.
Konstantinos Tsingas et al.
Melanoma is a common and aggressive cancer, with rising incidence in most developed countries. Major discoveries in melanoma biology have been rapidly translated, allowing cures for patients in late-stage disease. Despite these advances, ma...
Synchronous spatiotemporal control of autophagy and organelle trafficking is necessary for infection by Magnaporthe oryzae [0.03%]
稻瘟菌感染需要自噬和细胞器运输的时空同步调控
Alice B Eseola,Xia Yan,Lauren S Ryder et al.
Alice B Eseola et al.
The blast fungus Magnaporthe oryzae infects plants using an appressorium that generates force to breach the leaf cuticle. Appressorium development follows a cell-cycle-regulated morphogenetic program requiring autophagy-associated death of ...
HSPA6 maintains IMPDH2 phosphorylation to regulate GTP synthesis for driving radioresistance of glioblastoma stem cells [0.03%]
HSPA6维持IMPDE2磷酸化以调节GTP合成驱动胶质母细胞瘤干细胞的放射抵抗性
Junlei Yang,Qiankun Lin,Danling Gu et al.
Junlei Yang et al.
Glioblastoma (GBM) is the most common and malignant primary brain tumor. Glioblastoma stem cells (GSCs) promote radioresistance and therapeutic failure, yet the underlying mechanisms remain unclear. Here, we show that heat shock protein HSP...
PDGF signaling regulates the adipocyte-to-fibroblast transition in wound healing [0.03%]
血小板源性生长因子信号通路调节伤口愈合中的脂肪细胞到纤维细胞转变事件
Longbiao Yao,Sunhye Jeong,Jacob Bass et al.
Longbiao Yao et al.
Adipocytes are plastic cells with the ability to transition into fibroblast-like cells during tissue repair or physiological remodeling. It is unclear how such transitions are regulated and whether they exemplify cell plasticity or merely a...