Aging restricts maturation of CXCL13+ T follicular helper cells in human immunity [0.03%]
衰老限制了CXCL13+滤泡辅助性T细胞在人类免疫中的成熟
Nathan A Bracey,Casey Beppler,Tatjana Bilich et al.
Nathan A Bracey et al.
A decline in specific antibody responses is a hallmark of human aging, yet the differential contributions of B and T lymphocytes remain unclear. CXCL13 is a chemokine that shapes germinal center (GC) organization, but the regulation of huma...
Circuit organization and transcriptomic heterogeneity of sympathetic circuits innervating cranial structures [0.03%]
支配头部结构的交感神经环路的电路组织和转录组异质性
Gokhan Senturk,Shawn Driscoll,Peter J Osseward nd et al.
Gokhan Senturk et al.
The superior cervical ganglion (SCG) innervates multiple effector organs within cranial tissues and elicits responses including pupil dilation, piloerection, vasoconstriction, and inhibition of salivation. Coordinated activation of these ta...
Cisplatin resistance in an ovarian cancer model is mediated by microtubule dynamics regulator TPPP3 in synergy with tubulin code rewiring [0.03%]
TPPP3与微管蛋白密码重排协同介导卵巢癌模型的顺铂耐药性
Sachi Horibata,Kishore K Mahalingan,Ruchi Patel et al.
Sachi Horibata et al.
Cisplatin is a mainstay in cancer treatment, but toxicity and resistance limit its potential. Using RNA sequencing (RNA-seq), we show that ovarian cancer cells undergo broad changes in the microtubule cytoskeleton that correlate with resist...
A progenitor cell population contributes to prenatal injury repair and neonatal antimicrobial defense in the small intestine [0.03%]
一个祖细胞群参与小肠产前损伤修复和产后抗菌防御
Yonghui Shen,Chunlin Li,Hanqiong Zhang et al.
Yonghui Shen et al.
The specialized types and functions of epithelial cells in the adult small intestine have been well elucidated, but remain poorly understood in the embryonic small intestine. Through integrating single-cell RNA sequencing with functional st...
Nerve-proximal tertiary lymphoid structures predict chemotherapy sensitivity in pancreatic cancer [0.03%]
神经近端三级淋巴器官结构可预测胰腺癌对化疗的敏感性
Shuqi Cai,Min-Wei Yang,Luju Jiang et al.
Shuqi Cai et al.
The complex interplay between nerves, immunity, and tumor progression remains poorly understood, particularly in the context of chemotherapy. Here, we investigated how neural remodeling influences tertiary lymphoid structures (TLSs) and cli...
Cristina Nuevo-Tapioles,Zhihua Qin,Andrew Bazley et al.
Cristina Nuevo-Tapioles et al.
Among the ways by which oncogenic KRAS upregulates glycolysis in cancer is direct interaction of KRAS4A with hexokinase 1 (HK1), but the mechanism is unknown. HK1 associates with the outer mitochondrial membrane (OMM) where its allosteric r...
Chromosome-scale genomes of water lilies provide evolutionary insights into the aquatic adaptation of angiosperms [0.03%]
水生植物睡莲的染色体级别基因组为被子植物的水生适应性进化提供见解
Hongbin Zhang,Xin-Cheng Huang,Guanhua Liu et al.
Hongbin Zhang et al.
The origin and diversification of angiosperms, particularly their ancestral ecological niche, remain an enduring mystery. While competing hypotheses exist, the genomic mechanisms driving repeated transitions to aquatic life are poorly under...
Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain [0.03%]
空间分子基因表达反映了人类大脑背内侧前额叶皮层的结构和功能
Kinnary Shah,Michael S Totty,Svitlana V Bach et al.
Kinnary Shah et al.
The human brain's dorsal anterior cingulate cortex (dACC) is critical in cognitive control, specifically reward processing and conflict monitoring, and regulates fear and pain expression. The dACC is evolutionarily older than more recently ...
Heterologous betacoronavirus spike immunization in non-human primates elicits antibodies that neutralize both sarbeco- and merbecoviruses [0.03%]
异源贝塔冠状病毒刺突免疫在非人类灵长类动物中产生能同时中和萨贝科病毒和美贝科病毒的抗体
Katharina Dueker,Tazio Capozzola,Ziqi Feng et al.
Katharina Dueker et al.
In anticipation of future coronavirus (CoV) pandemics, developing vaccines that elicit broadly neutralizing antibodies (bnAbs) against diverse CoVs is critical. Here, we vaccinated rhesus macaques with the SARS-CoV-2 spike (S)-protein, then...
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer [0.03%]
PTHLH调节剂在受体酪氨酸激酶驱动的癌症中诱导抗药基因PHLDA1的表达
Abbie E Fearon,Edward P Carter,Natasha S Clayton et al.
Abbie E Fearon et al.
Published Erratum
Cell reports. 2026 Jun 3;45(6):117552. DOI:10.1016/j.celrep.2026.117552 2026