IL-33/TGF-β/IL-4-induced bone marrow-derived DC9 subset promotes Th9 differentiation and allergic airway inflammation [0.03%]
IL-33/TGF-β/IL-4诱导的骨髓来源DC9亚群促进Th9分化和过敏性气道炎症
Yifang Chen,Qian Zhang,Na Li et al.
Yifang Chen et al.
Dendritic cells (DCs) are professional antigen-presenting cells that exhibit significant heterogeneity in development and function. This study found that among 17 cytokines screened, only IL-33 could induce DCs to display a Th9-type cytokin...
Anterior lateral motor cortex enables contextual decision-making via dynamic reconfiguration of local circuits [0.03%]
前运动皮层通过局部环路的动态重构实现情境决策能力
Jia Shen,Nuttida Rungratsameetaweemana,Prayshita Sharma et al.
Jia Shen et al.
Cognitive operations often require flexible implementation of stimulus-response contingencies, depending on context. We developed an olfactory task in which mice learned to associate a test odor with a directional lick response, conditional...
Piezo2 tension sensitivity and its modulation by alternative splicing [0.03%]
Piezo2的张力敏感性及其通过可变剪接进行调节
Michael Sindoni,William Sharp,Jörg Grandl
Michael Sindoni
Piezo2 is a force-gated ion channel that functions as a sensor of mechanical touch, proprioception, lung inflation, and gut transit. Human Piezo2 contains seven domains that are alternatively spliced in a tissue-specific fashion resulting i...
Catalytic footprints of DNMT1 dynamics during mammalian cell state transitions [0.03%]
DNMT1动态在哺乳动物细胞状态转换过程中的催化印记
Vaidotas Stankevičius,Kotryna Kvederavičiūtė,Liepa Gasiulė et al.
Vaidotas Stankevičius et al.
5-methylcytosine is a reversible regulatory mark in mammalian genomes whose distribution varies across genetic loci, cell types, and disease conditions. Cytosine-5 methylation is brought about by three AdoMet-dependent DNA methyltransferase...
Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex [0.03%]
情感词汇在人脑丘脑和皮层中诱发特异的神经调质共变模式
Seth R Batten,Alec E Hartle,Leonardo S Barbosa et al.
Seth R Batten et al.
Published Erratum
Cell reports. 2026 Jun 5;45(6):117578. DOI:10.1016/j.celrep.2026.117578 2026
Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos [0.03%]
小鼠体外受精胚胎的胚外组织基因异常H3K4me3修饰导致胎盘缺陷和着床失败
Dandan Bai,Jin Sun,Chuan Chen et al.
Dandan Bai et al.
Published Erratum
Cell reports. 2026 Jun 5;45(6):117585. DOI:10.1016/j.celrep.2026.117585 2026
Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis [0.03%]
细胞类型和状态解析转录组揭示了多发性硬化中T细胞和单核细胞的特异性失调现象
Tina Roostaei,Masashi Fujita,Hanane Touil et al.
Tina Roostaei et al.
Multiple sclerosis (MS) is a complex immune-mediated disorder with polygenic and multicellular underpinnings, necessitating cell-type-specific molecular studies to delineate dysregulated pathways. Here, we profile 1,075 transcriptomes from ...
The C-terminal region of TENT5 proteins drives ER-associated mRNA polyadenylation via FNDC3 interaction [0.03%]
TENT5蛋白的C端结构域通过与FNDC3相互作用驱动内质网相关mRNA多腺苷酸化
Lisa Viviani,Daniel Lacidogna,Sara Pennacchio et al.
Lisa Viviani et al.
Spatial regulation of mRNA polyadenylation emerges as a key mechanism shaping cellular function. The TENT5/FAM46 family comprises four non-canonical poly(A) polymerases that stabilize transcripts encoding ER-targeted proteins, with mutation...
NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection [0.03%]
NRF2介导的结核分枝杆菌感染过程中肺泡巨噬细胞MHCII类分子表达抑制作用机制研究
Linh K Pham,Maritza M Cervantes,Pamelia N Lim et al.
Linh K Pham et al.
During Mycobacterium tuberculosis (Mtb) infection, infected alveolar macrophages (AMs) initially up-regulate a nuclear factor erythroid 2-related factor 2 (NRF2)-regulated cell-protective program, which is detrimental to host control and im...
Socially shared emotions shape the activity of the medial prefrontal cortex during inference of others' emotional states [0.03%]
社会共享情绪在推断他人的情绪状态时塑造中前额皮层的活动
Marine Le Petit,Pierre Gagnepain,Alexandre Bejanin et al.
Marine Le Petit et al.
The medial prefrontal cortex (mPFC) weighs options during decision-making, but its role in inferring competing emotional states and how this process changes with age, remain unclear. We recorded brain activity with functional MRI while 20 y...