Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins [0.03%]
RNA结合蛋白ZC3H7A和ZC3H7B对蛋白质翻译和mRNA稳定性的协调调控作用
Patric Harris Snell,Parisa Naeli,Aitor Garzia et al.
Patric Harris Snell et al.
mRNA translation and stability are tightly regulated and functionally linked through cis-acting sequence elements and trans-acting factors, including RNA-binding proteins (RBPs). Here, we report that two chordate-specific paralogous RBPs, Z...
The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis [0.03%]
MLLT3YEATS结构域结合组蛋白修饰(H3K9/18/27ac/cr)和ncRNA(7SK)，连接转录与RNA信号传导以调控血液发育
Adam Boulton,Ashish Kabra,Nicholas Achille et al.
Adam Boulton et al.
MLLT3 (AF9) is a critical regulator of hematopoiesis. The YEATS domain of MLLT3 binds to acylated histones (H3K9ac/cr). We showed that the YEATS domain also binds to RNA. PAR-CLIP data demonstrated binding to the snRNA 7SK. Biochemical stud...
RNA-programmable cell-type monitoring and manipulation in the human cortex with CellREADR [0.03%]
具有CellREADR的RNA编程的人脑皮层细胞类型监测和操作技术
Elizabeth A Matthews,Jeffrey B Russ,Yongjun Qian et al.
Elizabeth A Matthews et al.
Published Erratum
Cell reports. 2026 Jun 10;45(6):117589. DOI:10.1016/j.celrep.2026.117589 2026
Peptide-MHC-targeted engineered virus-like particles enable selective priming and gene editing of tumor-specific T cells [0.03%]
针对肽-MHC的工程病毒样颗粒能够选择性地激活并进行基因编辑以识别肿瘤抗原的T细胞
Brian H Shim,Q Henry Zhao,Jack A Queenan et al.
Brian H Shim et al.
Tumor-infiltrating lymphocyte (TIL) therapies harness tumor-specific T cells endogenous to a patient's repertoire but their efficacy is limited by challenges such as low frequencies of tumor-specific clonotypes and dysfunctional T cell phen...
STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy [0.03%]
TBK1依赖的线粒体自噬介导的STING-OPTN信号通路细胞保护作用
Ze-Bo Huang,Jin-Yi Lin,Ling-Jun Cheng et al.
Ze-Bo Huang et al.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays an essential role in innate immunity. While recent studies have revealed its critical role in non-canonical autophagy independent of its immune function...
Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence [0.03%]
Hedgehog信号使能定义的内皮前体细胞向横纹肌肉瘤转分化
Katherine E Gadek,Catherine J Drummond,Hongjian Jin et al.
Katherine E Gadek et al.
Published Erratum
Cell reports. 2026 Jun 9;45(6):117591. DOI:10.1016/j.celrep.2026.117591 2026
Cholera-toxin-induced disease generates epithelial-cell-derived L-lactate that promotes Vibrio cholerae growth in the small intestine [0.03%]
霍乱毒素引起的疾病产生上皮细胞来源的L-乳酸以促进霍乱弧菌在小肠内的生长
Maria de la Paz Gutierrez,Jenna L Hall,Hugo L P Masson et al.
Maria de la Paz Gutierrez et al.
Cholera toxin (CT) promotes Vibrio cholerae colonization by altering gut metabolism to favor pathogen growth. Here, we show that CT-induced disease leads to the upregulation of mammalian lactate dehydrogenase A (LDHA), an enzyme that cataly...
Human J-domain proteins promote stress granule disassembly and suppress neurodegeneration-linked protein aggregation [0.03%]
人源J型结构域蛋白促进应激颗粒解聚并抑制与神经退行性病变相关的蛋白质聚集
Giovanni J Mastromarco,Rebecca Earnshaw,Gaelen Moore et al.
Giovanni J Mastromarco et al.
Stress granules are conserved biomolecular condensates that form under stress and rapidly disassemble during recovery. Stress granules have been linked to pathological protein aggregation and their impaired disassembly reduces cell viabilit...
Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells [0.03%]
乙酰化和磷酸化在小鼠胚胎干细胞LIFR依赖的自我更新生长信号传导中的相反作用
Xiong-Jun Wang,Yunbo Qiao,Minzhe M Xiao et al.
Xiong-Jun Wang et al.
Published Erratum
Cell reports. 2026 Jun 9;45(6):117592. DOI:10.1016/j.celrep.2026.117592 2026
Endurance exercise elicits temporal and sexual dimorphic multi-omics remodeling of liver metabolism revealed by MoTrPAC [0.03%]
持久运动引起的肝脏代谢时空动态变化的多组学重塑：基于MoTrPAC研究结果
Taylor J Kelty,Edziu Franczak,Nicole R Gay et al.
Taylor J Kelty et al.
The mechanisms by which exercise modulates liver metabolism are poorly understood. Leveraging data from molecular transducers of physical activity consortium (MoTrPAC), we analyzed liver adaptations across 1, 2, 4, and 8 weeks of exercise i...