Protection and deprotection of the Rec8 cohesin complex during meiosis [0.03%]
同源重组过程中Rec8粘连复合物的保护与去保护
Yongxin Liu,Ke Zhang,Ziteng Bai et al.
Yongxin Liu et al.
During meiosis I, the cohesin Rec8 is cleaved by separase along the chromosome arms but is protected at the centromere by shugoshin (Sgo1); during meiosis II, it is not protected. In fission yeast, another meiotic regulator, meikin (Moa1), ...
High glucose impairs cognitive function by inducing lipid droplet accumulation through lactylation of HSD17B10 at K105 [0.03%]
高血糖通过HSD17B10赖氨酸105位乳酰化诱导脂滴聚集从而损害认知功能
Jingxi Xu,Jingxue Cao,Xing Yang et al.
Jingxi Xu et al.
High glucose is known to impair cognitive function in individuals with type 2 diabetes, though the precise mechanisms remain unclear. In this study, guided by lactylome analysis, we demonstrate that high glucose induces HSD17B10 K105 lactyl...
Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis [0.03%]
饥饿诱导的磷酸化激活气发育素A以启动焦亡
Xinran Li,Xiao Li,Cong Xiang et al.
Xinran Li et al.
Published Erratum
Cell reports. 2026 Jun 11;45(6):117594. DOI:10.1016/j.celrep.2026.117594 2026
STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation [0.03%]
STING通过抑制未折叠蛋白反应，在炎症期间促进自身抗原在MHC-I上的呈递
Ahmed M Fahmy,Ali Ahmadi,Joël Lanoix et al.
Ahmed M Fahmy et al.
A growing body of evidence supports the contribution of the long-lasting adaptive immune system in Parkinson's disease (PD). We showed that the PD-associated protein PINK1 negatively regulates the presentation of mitochondrial antigens (Mit...
Microglial states associate with lesion dynamics in multiple sclerosis [0.03%]
少突胶质细胞状态与多发性硬化的病变动力学相关
Aletta M R van den Bosch,Jia Hui Khoo,Zhigang Lu et al.
Aletta M R van den Bosch et al.
Multiple sclerosis (MS) is a neuroinflammatory disease of the CNS characterized by demyelinating lesions. Lesion expansion contributes to disability progression, whereas remyelination may restore neurological function. How these divergent o...
Lateral habenula 5-HT4 receptor signaling restores social novelty preference after acute isolation [0.03%]
急性隔离后恢复社交新颖性偏好的缰侧核5-羟色胺4型受体信号机制
Miseon Kang,Sukwoon Song,Beomsue Kim et al.
Miseon Kang et al.
Social homeostasis-the maintenance of stable social contact-is disrupted by acute social stressors such as isolation. While the lateral habenula (LHb) is known for encoding negative emotional salience, it also modulates social behavior. How...
Collective cell migration plasticity in patient-derived digestive cancer organoids is dictated by environment sensing and contractility [0.03%]
患者来源的消化系肿瘤类器官的集体细胞迁移可塑性由环境感知和收缩性决定
Clémence Nguyen-Vigouroux,Elise Carraz-Billat,Tatiana Cetenovic et al.
Clémence Nguyen-Vigouroux et al.
The metastatic dissemination of individual cells or cell collectives is a decisive step in the progression of cancers. Migrating single cells dynamically switch between mesenchymal traction-based and amoeboid propulsion-based modes of migra...
The circadian clock component BMAL1 enhances macrophage inflammation by nuclear translocation of peroxisomal β-oxidation enzyme MFP2 [0.03%]
核转位的过氧化物酶体β氧化酶MFP2增强BMAL1昼夜节律钟组件对巨噬细胞的炎症作用
Akito Tsuruta,Nodoka Hirao,Megumi Shibata et al.
Akito Tsuruta et al.
The circadian clock regulates diverse immune functions, yet the role of clock components in macrophage inflammation remains controversial, with both pro- and anti-inflammatory effects reported. Here, we identify a previously unrecognized me...
Bilirubin mitigates ischemic white matter injury by targeting transferrin-receptor-mediated B cell immunometabolism [0.03%]
胆红素通过靶向转铁蛋白受体介导的B细胞免疫代谢缓解缺血性白质损伤
Lian Chen,Xiao-Wei Pang,Zhi-Cheng Mei et al.
Lian Chen et al.
Physiological bilirubin exerts protective effects against ischemic stroke, but its role in post-stroke white matter injury (WMI) remains unclear. Here, through integrated epidemiological, genetic, and mechanistic studies, we demonstrate tha...
B cell TET2 recruits OGT for nuclear TET2 and H2B O-GlcNAcylation to drive AID and BLIMP-1 expression and maturation of the antibody response [0.03%]
B细胞TET2招募OGT促进核内TET2和H2B O-GlcNAc酰化驱动AID及BLIMP-1表达和抗体应答的成熟
Shili Li,Yibo Peng,Zhimin Yang et al.
Shili Li et al.
Maturation of antibody responses entails B cell Aicda/AID and Prdm1/BLIMP-1 expression for SHM/CSR, plasma cell differentiation, and production of class-switched high-affinity antibodies. We determined that TET1, TET2, and TET3 are not expr...