Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts [0.03%]
循环细胞衰老标志物在人类纵向队列中追踪不同的健康状态和轨迹维度
Bradley Olinger,Carlos Anerillas,Allison B Herman et al.
Bradley Olinger et al.
Cellular senescence is implicated in age-related pathologies, and identifying circulating biomarkers of senescence holds great diagnostic potential. Circulating senescence signatures are predictive of age-related traits and diseases, though...
Nucleoplasmic checkpoint of the 40S ribosomal decoding center maturation [0.03%]
40S核糖体解码中心成熟的细胞核检查点
Benjamin Lau,Yi Li,Jingyi Zhu et al.
Benjamin Lau et al.
The decoding center (DC) is a key ribosomal structure for accurate translation, assembled in a multi-step process that starts on nucleolar pre-ribosomes and ends in the cytoplasm. While late cytoplasmic steps and their checkpoint mechanisms...
Synergistic cooperation between progranulin and Jak2/Stat3 signaling determines definitive myeloid cell fate [0.03%]
progranulin与Jak2/Stat3信号协同合作决定定型髓系细胞命运
Abbigail McCune,Masuma Khatun Usha,Inga Baldus et al.
Abbigail McCune et al.
Perturbations in cell fate disrupt tissue homeostasis and drive diseases such as cancer. The JAK/STAT pathway is central to hematopoietic malignancies, yet its regulators in cell fate decisions remain poorly defined. Here, we identify progr...
Glia-released serotonin drives nose touch responses in Caenorhabditis elegans [0.03%]
秀丽隐杆线虫神经胶质释放的血清素传递触须刺激反应
David R Logan,Carlos D Oliva,Lei Wang et al.
David R Logan et al.
Touch is essential for survival, guiding interactions with the environment and forming the basis of social and emotional connection. While touch perception is mediated by mechanoreceptors composed of neurons and glia, the role of glia in me...
Dong Shin You,Christopher H Bohrer,Purva H Rumde et al.
Dong Shin You et al.
Increasing cell size drives proteomic changes that impact cell physiology. However, the molecular basis of size-dependent proteome remodeling has remained unclear. Here, we develop an inducible Cyclin D1 expression system in human cells to ...
Genome-wide histone humanization in yeast disrupts genome organization, replication, and rDNA stability [0.03%]
在酵母中全基因组范围的组蛋白人类化干扰基因组组织、复制和rDNA稳定性
Luciana Lazar-Stefanita,Max A B Haase,Dana Branzei et al.
Luciana Lazar-Stefanita et al.
Eukaryotic DNA wraps around histone octamers forming nucleosomes, which modulate genome function by defining chromatin environments with distinct accessibility. These well-conserved properties allowed "humanization" of the nucleosome core p...
Amplification of MED30 at chromosome 8q24 reprograms MYC binding to low-affinity oncogenic enhancers in cancer cells [0.03%]
染色体8q24位点的MED30扩增通过重新编程MYC与癌症细胞中低亲和力致癌增强子的结合而促进癌基因活化
Chunyu Jin,Linjie Zhao,Wubin Ma et al.
Chunyu Jin et al.
The activity of many oncogenic transcription factors (TFs) is constrained by enhancer binding-site affinity, leaving many low-affinity sites unoccupied under physiological conditions. Whether coactivator amplification in cancer redirects TF...
Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts [0.03%]
来自两种进化上相距甚远的酵母的肌动蛋白丝的快速老化和解体
Ingrid Billault-Chaumartin,Hugo Wioland,Audrey Guillotin et al.
Ingrid Billault-Chaumartin et al.
Similarities and differences in the self-assembly of actin filaments from different species inform our understanding of its evolution. However, this basic knowledge is largely incomplete. Here, we systematically characterize assembly kineti...
A natural nucleotide variation in the MIR172C promoter modulates temperature-dependent plant height in maize [0.03%]
一个新的MIR172C启动子自然变异体调控玉米的温度依赖株高反应
Tao Wang,Binbin Hu,Lifeng Wang et al.
Tao Wang et al.
Temperature has a severe impact on maize height. However, the mechanisms by which maize regulates height in response to heat have not been fully established. Here, we perform a genome-wide association study and identify one single nucleotid...
RNF138 promotes cisplatin resistance and PD-L1-mediated immune evasion via JAK2/STAT3 activation in nasopharyngeal carcinoma [0.03%]
RNF138通过激活JAK2/STAT3促进鼻咽癌顺铂抗药性及PD-L1介导的免疫逃逸
Chuyu He,Liming Lou,Yuan Lei et al.
Chuyu He et al.
Chemoresistance is a primary factor limiting nasopharyngeal carcinoma (NPC) treatment. Growing evidence indicates that E3 ubiquitin ligases play a pivotal role in chemoresistance. Here, we identified that the E3 ubiquitin ligase RNF138 is s...