Multiple broadly neutralizing antibody lineages can co-exist and mature in the same germinal centers [0.03%]
多种广泛中和抗体谱系可以在同一生发中心共存并成熟
Amar Kumar Garg,Sebastian C Binder,Michael Meyer-Hermann
Amar Kumar Garg
An efficacious HIV vaccine will need to generate broadly neutralizing antibodies (bnAbs) against distinct viral epitopes. To facilitate this, immunogens targeting precursor B cells of bnAbs have been developed. With this strategy, individua...
RBFOX2 suppresses NETosis and glioma growth via 5hmC-dependent PDGFB decay [0.03%]
RBFOX2通过5hmC依赖的PDGFB降解抑制NETosis和胶质瘤生长
Xi Chen,Weiwei Dai,Hanlin Wang et al.
Xi Chen et al.
Neutrophil extracellular traps (NETs) are increasingly recognized as key regulators of tumor progression, yet the molecular circuitry that governs their induction in cancer remains elusive. Here, we identify the RNA-binding protein RBFOX2 a...
Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer [0.03%]
mutant KRAS驱动的选择性mrna翻译揭示了癌症中的作用机制和治疗弱点
Ankita Shrivastava,Eric Nels Pederson,Trang Uyen Nguyen et al.
Ankita Shrivastava et al.
Mutant KRAS-driven control of protein synthesis remains poorly defined. Here, we define KRAS-dependent translational programs and their acute remodeling upon KRAS inhibition. We find that mutant KRAS controls the translation of a subset of ...
Synaptonemal complex SUMOylation is maintained by Nup60-dependent docking of Ulp1 at the nuclear periphery [0.03%]
由Nup60依赖性地将Ulp1定位到核周维持的黏连素复合物SUMO化
Rahel Wettstein,Grant A King,Adrian Henggeler et al.
Rahel Wettstein et al.
The nuclear pore complex (NPC) basket has been implicated in regulating meiotic recombination, but the underlying mechanism remained elusive. Here, we show that most basket subunits are required for controlled crossing-over in budding yeast...
Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling [0.03%]
基于细胞类型特异性的临近标记鉴定器官分泌组并揭示能量平衡介导的蛋白质组重编程
Kaja Plucińska,Charlotte R Wayne,Henry Sanford et al.
Kaja Plucińska et al.
Intercellular communication is critical for maintaining organismal metabolic homeostasis. Here, we develop a method enabling temporally controlled, cell-type-specific labeling of secreted and membrane proteins in key metabolic tissues. The ...
Female mice with a Xist deletion in B cells can develop lupus-associated phenotypes [0.03%]
Xist基因缺失的B细胞导致小鼠产生系统性红斑狼疮表型
Claudia D Lovell,Nikhil Jiwrajka,Natalie E Toothacre et al.
Claudia D Lovell et al.
Systemic lupus erythematosus (SLE) is an autoimmune disease preferentially observed in women. X-linked gene expression in XX females is equalized with that in XY males by X chromosome inactivation (XCI). However, B cells from female patient...
A hypothalamic VMPO-supraoptic vasopressin circuit mediates procalcitonin-induced fluid imbalance [0.03%]
降钙素原通过下丘脑VMPO-室旁核血管紧张素通路介导体液失衡
Wei Lin,Tingjun Liu,Jinfeng Huang et al.
Wei Lin et al.
Sepsis is a life-threatening condition characterized by infection-induced organ dysfunction, with fluid imbalance and cardiovascular instability as cardinal features. Although circulating procalcitonin (PCT) is widely used as a diagnostic a...
Fgf18 marks reserve skeletal progenitors in the fibrous periosteum contributing to bone fracture repair [0.03%]
FGF18标记纤维密质骨膜中的骨骼干细胞参与骨折修复
Xing Ji,Jasmin Koehnken Sawall,Xuejun Zhang et al.
Xing Ji et al.
The periosteum, a thin membranous tissue covering the external bone surface, is a well-established source of osteogenic activity during bone growth and fracture repair. However, the molecular identity and anatomical niche of its progenitor ...
Structural and genetic basis for broad antibody recognition of a protective epitope on orthomarburgvirus GP2 [0.03%]
结构基础和遗传机制使抗体能够广泛识别正马堡病毒GP2保护性表位
Aurelie Niyongabo,Benjamin M Janus,Fabrizio G Gonzalez et al.
Aurelie Niyongabo et al.
Orthomarburgviruses are the etiological agents of human Marburg virus disease, with case fatality rates reaching up to 90%. Of the limited known targets for protective antibodies on the orthomarburgvirus surface glycoprotein (GP), the GP2 w...
Cancer-associated fibroblast subtypes differentially modulate natural killer cells in cancer [0.03%]
癌症相关成纤维细胞亚型对癌症中自然杀伤细胞的差异调节作用
Leonor Nunes Rodrigues,Hafsa Munir,Ibone Thate Arrazola et al.
Leonor Nunes Rodrigues et al.
Natural killer (NK) cells are cytotoxic innate lymphoid cells which directly kill tumor cells, thus represent an attractive target for immunotherapy. However, NK cells face immunosuppression in the tumor microenvironment (TME), rendering th...