Microbial metabolites at the front line: Orchestrating gastrointestinal and systemic barrier immunity across the lifespan [0.03%]
微生物代谢产物位于前沿：一生中协调胃肠道和全身屏障免疫反应
Omry Koren,Maria Carmen Collado,Benoit Chassaing et al.
Omry Koren et al.
Microbiota-derived metabolites are central mediators between commensal microbes and host immune system at mucosal barrier surfaces. Insights from mouse models have revealed precise molecular mechanisms by which numerous metabolites, includi...
ARF19 acts as a transient auxin response enhancer during root gravitropism [0.03%]
在根向地性中，ARF19作为瞬时的生长素响应增强因子发挥作用
Erfan Ghafouri,Kristine Hill,Nathan Mellor et al.
Erfan Ghafouri et al.
Root gravitropism is regulated by an auxin gradient, causing the root to reorient downwards with gravity. Transcriptional activator auxin response factors (ARFs), such as ARF5, ARF6, ARF7, ARF8, and ARF19, play key roles in auxin signaling ...
Whole-neuron morphology and genetic identity define cell types and reveal principles of brain-wide connectivity [0.03%]
全神经形态和基因身份定义细胞类型并揭示全脑连接原则
Yun Wang,Hsien-Chi Kuo,Xiuli Kuang et al.
Yun Wang et al.
Neocortex contains diverse excitatory neurons whose dendritic and axonal architectures shape computation and long-range communication, yet a unified framework linking neuronal structure, molecular identity, and brain-wide connectivity is la...
Convergent molecular signatures across eating disorders and obsessive-compulsive disorder in the human brain [0.03%]
人脑中饮食紊乱和强迫症的趋同分子特征
Michael S Breen,Ran Tao,Andy Yang et al.
Michael S Breen et al.
Eating disorder (ED) and obsessive-compulsive disorder (OCD) exhibit clinical and genetic overlap, yet whether they converge at the molecular level in the human brain is unknown. We perform large-scale transcriptomic profiling of the dorsol...
Lonicera japonica polysaccharide restores mucosal integrity in ulcerative colitis by increasing microbiota-derived spermidine [0.03%]
日本honeysuckle多糖通过增加微生物源精胺修复溃疡性结肠炎黏膜完整性
Xinyu Bai,Xiuming Rao,Keke Tian et al.
Xinyu Bai et al.
WLJP-025p, a homogeneous polysaccharide from Lonicera japonica Thunb., alleviates experimental ulcerative colitis in mice by reshaping the gut microbiota and restoring intestinal spermidine. Microbial fermentation, microbiota depletion, and...
Co-transcriptional splicing regulation in FLC mediated by AtCDC5 and AtSYF2 regulates plant flowering [0.03%]
AtCDC5和AtSYF2介导的FLC基因转录依赖性剪接调控控制植物开花时间
Yuan Tian,Ping Lin,Min Li et al.
Yuan Tian et al.
Co-transcriptional splicing plays a crucial role in eukaryotic gene expression. However, its specific effects on growth, development, and stress responses in animals and plants are still not fully understood. In this study, we screen for a ...
Mitotic phosphorylation of the microtubule nucleator γ-tubulin regulates spindle assembly [0.03%]
微管发起体γ-微管蛋白的有丝分裂磷酸化调节纺锤体装配
Gefei Li,Khoi T D Le,Yi Duan et al.
Gefei Li et al.
The assembly of cellular microtubules relies heavily on γ-tubulin ring complex (γTuRC), a macromolecular assembly of γ-tubulin and associated proteins that serves as a nucleation template. Here, we identify that within γTuRC, γ-tubulin...
MYCN drives pediatric glioma transformation from neural progenitors and creates distinct therapeutic vulnerabilities [0.03%]
MYCN驱动儿童神经胶质瘤干细胞的恶性转化并产生不同的治疗靶点
Taylor A Gatesman,Srinidhi Varadharajan,Brenden J Johnson et al.
Taylor A Gatesman et al.
MYCN functions as a developmental oncogene, but its role in pediatric high-grade gliomas (pHGGs) remains unclear. In co-operation with Trp53 and Pten loss, MYCN initiates tumorigenesis and establishes an origin for MYCN-driven pHGGs. This t...
SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism [0.03%]
ORF3a阻断VPS39调控的NPC2胆固醇转运和BMP代谢使囊腔膜胆固醇蓄积
Baley A Goodson,Valeria Montenegro Vazquez,Aliza Doyle et al.
Baley A Goodson et al.
Cholesterol homeostasis depends on lysosomes liberating cholesterol from degraded lipids. We show that SARS-CoV-2 blocks lysosomal cholesterol egress through the viral protein ORF3a. ORF3a binds the HOPS subunit VPS39 via the W193 and Y184 ...
Alternative 3' UTRs and RNA-binding proteins Ewsr1b, HuR, and Syncrip organize sequential waves of translation to drive embryonic development [0.03%]
备选的3'UTR和RNA结合蛋白Ewsr1b、HuR及Syncrip分阶段组织翻译以驱动胚胎发育
Keisuke Sato,Ludivine Fierro,Anyu Suginishi et al.
Keisuke Sato et al.
Eggs of many species accumulate thousands of dormant mRNAs that are translated after fertilization at specific times and locations to direct development. However, how embryos coordinate translation of these mRNAs remains unclear. In this st...