Distinct ERK and PI3K dependencies mediate a heterogeneous response to RAS(ON) inhibition in KRAS-mutant colorectal cancer [0.03%]
不同的ERK和PI3K依赖性介导了KRAS突变型结直肠癌对RAS(ON)抑制的异质性反应
Philip H Choi,Julia Meredith,Malvika Sharma et al.
Philip H Choi et al.
RAS inhibitors have demonstrated limited efficacy in KRAS-mutant colorectal cancer (CRC). Here, we evaluate RMC-7977, a RAS(ON) multi-selective inhibitor, which shows a heterogeneous response in a panel of preclinical CRC models. Inhibition...
GlycoBond X enables isomer-resolved milk oligosaccharide glycomics and reveals evolutionary divergence across four mammalian species [0.03%]
一种新型糖链连接技术揭示了四种哺乳动物乳寡糖糖组学的异构体及进化差异
Tianjiao Han,Yuxia Liu,Peiyun Zhong et al.
Tianjiao Han et al.
Milk oligosaccharides (MOs) are essential for the development of mammalian offspring, yet their fine-scale structural evolutionary divergence remains unelucidated, largely due to isomeric complexity and the limitations of analytical methods...
Fangping Han,Pengbo Sun,Yuanyuan Wei et al.
Fangping Han et al.
STING bridges innate and adaptive immunity to exert potent antitumor effects, and its agonists play emerging roles in combination therapies with tyrosine kinase inhibitors (TKIs). However, the interaction between STING and receptor tyrosine...
A central amygdala-locus coeruleus pathway mediating pain under chronic stress [0.03%]
支配慢性压力下疼痛的中央杏仁核-蓝斑通路
Jing Wei,An Liu,Yu Cao et al.
Jing Wei et al.
Chronic stress can induce pain and drive development of aversion, although the specific neural circuits that contribute to encoding such behavioral responses remain unclear. Here, we find that noradrenergic neurons in locus coeruleus (NELC)...
NSUN2-mediated m5C modification of BHLF1 RNA facilitates the lytic replication of Epstein-Barr virus [0.03%]
NSUN2介导的BHLF1 RNA m5C修饰促进EB病毒裂解复制
Tian-Liang Xia,Li-Qiang Tan,Ao Zhang et al.
Tian-Liang Xia et al.
The 5-methylcytosine (m5C) modification of mRNA mediates diverse cellular and viral functions. Epstein-Barr virus (EBV) is etiologically linked to multiple malignancies, including nasopharyngeal carcinoma (NPC), in which both viral latency ...
Compositional recombination is facilitated by a distributed cortico-cerebellar network [0.03%]
分布式皮层小脑网络促进组合式重组
Joshua B Tan,Isabella F Orlando,Jungwoo Kim et al.
Joshua B Tan et al.
Human cognition depends on the ability to flexibly recombine existing knowledge in new ways. Although this capacity for compositionality has traditionally been attributed to cortical networks, its broader neural basis remains unclear. We co...
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition [0.03%]
靶向p130Cas和微管依赖的MYC调节使胰腺癌对ERK MAPK抑制敏感
Andrew M Waters,Tala O Khatib,Bjoern Papke et al.
Andrew M Waters et al.
Published Erratum
Cell reports. 2026 Jun 17;45(7):117627. DOI:10.1016/j.celrep.2026.117627 2026
A multi-organ metabolomics atlas reveals molecular dysregulations in Alzheimer's disease mouse models [0.03%]
多器官代谢组学图谱揭示了阿尔茨海默病小鼠模型中的分子失调现象
Simone Zuffa,Celeste Allaband,Vincent Charron-Lamoureux et al.
Simone Zuffa et al.
The etiology of Alzheimer's disease (AD) remains unclear but is likely driven by gene-environment interactions. We present a multi-organ untargeted metabolomics atlas (n = 2,271) paired with metagenomics data (n = 666) from two AD transgeni...
Constraining regulatory domain dynamics of the Src kinase Fgr increases ATP-site inhibitor sensitivity and impairs bone marrow engraftment [0.03%]
限制Src激酶Fgr的调控域动力学可增加对ATP位点抑制剂的敏感性并损害骨髓植入能力
Giancarlo Gonzalez-Areizaga,Sherry T Shu,John J Alvarado et al.
Giancarlo Gonzalez-Areizaga et al.
Acute myeloid leukemia is often associated with constitutive activation of the Src-family kinases, Hck, Lyn, and Fgr. Their modular SH3 and SH2 domains regulate kinase activity and signal transduction. Here, we show that regulatory domain d...
Mechanisms of premotor-motor cortex interactions during movement initiation [0.03%]
运动发起过程中前运动皮层和运动皮层相互作用的机制
Mansour Alyahyay,Julian J Ammer,Gabriel Kalweit et al.
Mansour Alyahyay et al.
Preparing and initiating movements at the right time is critical for goal-directed behavior. Before movement execution, motor cortical areas exhibit preparatory activity, which decreases from premotor to primary motor areas. During the shif...