Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a membrane-bound TGF-β1-dependent mechanism [0.03%]
抑炎性髓样细胞通过膜结合TGF-β1依赖机制诱导类间质癌干细胞
Thomas Boyer,Céline Blaye,Domitille Chalopin et al.
Thomas Boyer et al.
Suppressive myeloid cells play a central role in cancer escape from anti-tumor immunity and exert multiple pro-tumoral activities, including the promotion of cancer cell survival, invasion, and metastasis. Recent evidence suggests that cert...
The pyruvate transporter hermes regulates autophagy and health by modulating ROS production [0.03%]
丙酮酸转运蛋白hermes通过调节ROS的产生来调控自噬和健康状态
Panagiotis D Velentzas,Fei Chai,Eric H Baehrecke
Panagiotis D Velentzas
Autophagy is a catabolic process that degrades cytoplasmic materials and is controlled by nutrient availability and signaling. The plasma membrane-associated pyruvate-solute carrier hermes (hrm) is required for regulation of the mechanistic...
Public antibody clonotypes and deep learning identify SARS-CoV-2 and HIV broadly neutralizing antibodies in immune repertoires [0.03%]
公共抗体克隆型和深度学习在免疫文库中识别针对SARS-CoV-2和HIV的广谱中和抗体
Lizhi Zhou,Zhili Yu,Shutian Lin et al.
Lizhi Zhou et al.
Broadly neutralizing antibodies (bnAbs) are essential for the development of vaccines and therapeutics against rapidly evolving pathogens like HIV and SARS-CoV-2, yet traditional discovery methods remain technically challenging and time con...
Trans-presentation of IL-6Rα by macrophages drives colorectal cancer development [0.03%]
巨噬细胞介导的IL-6Rα顺行转运驱动结直肠癌发生
Fanwu Gong,Qiming Zhang,Jiaojiao Qian et al.
Fanwu Gong et al.
IL-10-signaling-deficiency-induced macrophage hyperactivation drives epithelial barrier disruption and severe colitis, but its role in colitis-associated colorectal cancer (CAC) remains unclear. Here, we report that macrophage-specific IL-1...
Cunninghamia lanceolata genome illuminates the evolutionary dynamics of gymnosperms [0.03%]
南酸枣基因组揭示了裸子植物的进化动力学
Si-Zu Lin,Yu Chen,Chao Wu et al.
Si-Zu Lin et al.
Cupressaceae , a gymnosperm family, draws attention due to its controversial phylogenetic position. Here, we present a comprehensive genome analysis of Chinese fir (Cunninghamia lanceolata), a Cupressaceae species, to enhance our understand...
Multi-tier signaling and chromatin remodeling coordinate microglia inflammatory states and activities associated with demyelination [0.03%]
多层次信号转导和染色质重塑协调与脱髓鞘相关的微胶质细胞炎症状态和活性
Félix Distéfano-Gagné,Nesrine Belhamiti,William Saxon et al.
Félix Distéfano-Gagné et al.
Complex molecular mechanisms underlie the heterogeneity of microglia immune functions in neurodegenerative diseases. Here, we report on the transcriptional mechanisms that control microglial activities associated with demyelination in mice....
Microglial clonal dynamics and the impact of clonal hematopoiesis in autologously transplanted rhesus macaques [0.03%]
恒河猴自体移植后的微胶质细胞克隆动力学及克隆型造血的影响
Yifan Zhou,Diana M Abraham,Rohan V Hosuru et al.
Yifan Zhou et al.
Microglia are central nervous system (CNS)-resident macrophages, with key roles in immune surveillance, phagocytosis, and synaptic pruning. Yolk sac-derived microglia show minimal turnover from hematopoietic stem/progenitor cells (HSPCs) un...
Remodeling of the immune-metabolic landscape triggered by long-term high-altitude exposure [0.03%]
长期高海拔暴露引发的免疫代谢景观重塑
Jiaqi Wang,Yutong Dong,Ruoyi Xue et al.
Jiaqi Wang et al.
Immunometabolic remodeling drives adaptation to long-term high-altitude exposure (LTHAE), yet the underlying mechanisms remain elusive. By integrating single-cell transcriptomics and metabolomics from 46 lowlanders following a 90-day LTHAE,...
Src promotes tumor cell invasion by hijacking the translation machineries [0.03%]
Src通过劫持翻译机制促进肿瘤细胞侵袭
Benjamin Bonnard,Anouk Chatefau,Cyril Dourthe et al.
Benjamin Bonnard et al.
Published Erratum
Cell reports. 2026 Jun 18;45(7):117614. DOI:10.1016/j.celrep.2026.117614 2026
Embryonic dopaminergic neuron activity sustains lifelong locomotion in Drosophila [0.03%]
果蝇胚胎多巴胺能神经元活性维持一生的运动功能
Aishwarya Padmanabhan,Daniel Rahman,Ruibao Zhu et al.
Aishwarya Padmanabhan et al.
Locomotor skills arise early in life and are maintained throughout an animal's lifespan, yet how this continuity is achieved despite major neural remodeling remains unclear. Using Drosophila, which undergoes complete metamorphosis, we show ...