Lipid droplet-mitochondria tethering releases MAVS inhibition to potentiate antiviral immunity [0.03%]
甘油三酯滴-线粒体相互作用释放MAVS抑制以增强抗病毒免疫反应
Qianwen Peng,Wenbo Liang,Wei Wang et al.
Qianwen Peng et al.
Mitochondrial antiviral signaling protein (MAVS) forms prion-like aggregates to activate innate immunity against RNA viruses, but the metabolic regulation of MAVS remains poorly understood. Here, we show that viral infection induces the for...
Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling [0.03%]
激活诱导的SLC7A1表达增强T细胞对cGAMP介导的STING信号的敏感性
Valentino Sudaryo,Dayanne R Carvalho,Jacqueline A Carozza et al.
Valentino Sudaryo et al.
STING (stimulator of interferon genes) agonists are promising innate immune therapies and can be synergized with adaptive immune checkpoint blockade therapies for cancer treatment, but their effectiveness is limited by the toxicity to activ...
Pancreatic α-cells integrate immune and neuronal stimuli for insulin secretion [0.03%]
胰腺α细胞整合免疫和神经刺激以促进胰岛素分泌
Kelly A Trimigliozzi,Sophia J Wiedemann,Giada Ostinelli et al.
Kelly A Trimigliozzi et al.
Insulin secretion can be stimulated by immune and neuronal processes prior to a rise in blood glucose, exemplified by the cephalic phase of insulin response in the anticipation of food. Pancreatic α-cells prevent hypoglycemia by releasing ...
Mutant huntingtin disrupts TET1 transcription and alters DNA methylation in a Huntington's disease knock-in pig model [0.03%]
突变亨廷顿蛋白干扰TET1转录并改变亨廷顿病敲入猪模型的DNA甲基化状态
Leijie Xie,Xiaodong Liu,Can Zhang et al.
Leijie Xie et al.
Abnormal DNA methylation occurs in Huntington's disease (HD, but the underlying mechanisms remain unclear. Using a knock-in pig model, we identify significant alterations in 5mC and 5hmC levels linked to neural genes. TET1, which converts 5...
Comprehensive mapping of the virus and host factors that guide the paths of HIV-1 escape from a therapeutic [0.03%]
HIV-1逃逸药物治疗的宿主和病毒驱动因素的综合图谱测绘
Aaron N Gillman,Cassian M Birler,Rohith Rao Vujjini et al.
Aaron N Gillman et al.
HIV-1 resistance to therapeutics can emerge through diverse mutational routes, yet the determinants guiding pathway selection in vivo remain unclear. Through comprehensive screening, we identify 18 mutations in the HIV-1 Env protein that en...
Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations [0.03%]
弗姆1型敲-out小鼠行为抑制受损与视觉皮层theta振荡异常有关联
Michael P Zimmerman,Mowen Yin,Kevin R Cragg et al.
Michael P Zimmerman et al.
Fragile X syndrome (FX) is associated with sensory processing and learning deficits. Visual familiarity evokes persistent theta oscillations during passive stimulus presentation in the primary visual cortex (V1) and the hippocampus (HPC), w...
Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer [0.03%]
PD-1和NKG2A双联阻滞可防止NK细胞衰老并重新编程胰腺癌的免疫抑制微环境
Yu Zhang,Xueyan Zhou,Yuhao Wei et al.
Yu Zhang et al.
Immune checkpoint blockade (ICB) shows limited efficacy in pancreatic ductal adenocarcinoma (PDAC). Here, we demonstrate that ICB-induced IFN-γ signaling upregulates H2-T23 on pancreatic tumor cells, which interacts with NKG2A on NK cells ...
ISGylation mechanism uncovers conformational specificity for HECT-family E3 ligase HERC5 [0.03%]
泛素化机制揭示HECT家族E3连接酶HERC5的构象特异性
Pritiranjan Sahoo,Gloria Grace Parmar,Dipti Ranjan Lenka et al.
Pritiranjan Sahoo et al.
Interferon-stimulated gene 15 (ISG15), composed of two ubiquitin-like domains, plays a critical role in antiviral immunity. Although the ubiquitination mechanism is well established, the mechanisms governing ISG15 transfer, particularly fro...
Prophage induction contributes to alterations in the gut phageome during intestinal inflammation [0.03%]
肠道炎症期间肠道噬菌体群的变化与感应溶原有关
Anshul Sinha,Amy Qian,Tommy Boutin et al.
Anshul Sinha et al.
Bacteriophages (phages) are abundant members of the gut microbiota and regulators of bacterial communities. During homeostasis, gut phage communities are longitudinally stable and lysogenic replication is dominant. In chronic gut inflammato...
Osr1-expressing mesoderm contributes to lymphatic vessel assembly and complexity in the mammalian kidney [0.03%]
Osr1表达间叶组织参与哺乳动物肾脏淋巴管组装和复杂性的形成
Daniyal J Jafree,Lauren G Russell,Athanasia Stathopoulou et al.
Daniyal J Jafree et al.
Lymphatic vessels perform diverse functions, ranging from fluid homeostasis to immune regulation, and arise from multiple cellular origins to form organ-specific networks. Despite their importance in kidney disease and transplant immunity, ...