Utku Kaya,Md Jahangir Alam,Bapun Giri et al.
Utku Kaya et al.
Hippocampal theta oscillations coordinate computations underlying learning and memory. The frequency of theta varies with factors such as locomotion and anxiety, but the effect of an animal's sleep history on theta frequency remains unknown...
Recurrent ZC3H18 mutations stabilize oncogenic endogenous retroviral RNA [0.03%]
ZC3H18基因的复发性突变稳定致癌内源性逆转录病毒RNA
Tanzina Tanu,Anna M Cox,Jennifer A Karlow et al.
Tanzina Tanu et al.
Endogenous retroviral (ERV) RNA is highly expressed in cancer, suggesting a selective advantage. We identify recurrent truncating mutations in ZC3H18 (Z18), a nuclear RNA surveillance factor lost in 30% of all cancers. We show that Z18 trun...
De novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity [0.03%]
从头合成嘧啶控制生发中心B细胞和浆细胞的命运及全身自身免疫反应
Julia L Weber,Tien Bui,Keomonyroth Nuon et al.
Julia L Weber et al.
Whether and how pyrimidine metabolites promote systemic autoimmunity is unknown. Here, metabolomics and 15N-amide glutamine tracing show enhanced flux through de novo pyrimidine synthesis in systemic lupus erythematosus (SLE)-prone B cells....
Mrgpra2+ neutrophils integrate infection-derived signals to trigger NET-mediated antimicrobial defense in bone marrow [0.03%]
Mrgpra2+中性粒细胞整合感染衍生信号以触发骨髓中的NET介导的抗菌防御反应
Jie Zhang,Qixiu Yu,Ying Qu et al.
Jie Zhang et al.
Neutrophils are central mediators of innate defense in bone marrow, where infection rapidly reshapes local hematopoietic and immune niches. Here, we identify a subset of Mrgpra2+ neutrophils that supports antimicrobial immunity through neut...
Guido Wabnitz
Guido Wabnitz
Zhang and colleagues identify a Mrgpra2⁺ neutrophil subset that deploys neutrophil extracellular traps (NETs) in infected bone marrow. NET release requires coincident defensin and TNF-α signaling, a combination that defines a dual-signal ...
SPINDOC functions as a mitotic molecular counter to coordinate spatiotemporal CENP-A assembly [0.03%]
SPINDOC充当一种有丝分裂分子计数器以协调CENP-A装配的时空关系
Zixu Zhang,Xuechun Zhang,Yuting Liu et al.
Zixu Zhang et al.
Cell cycle-dependent maintenance of centromere protein A (CENP-A) levels and its spatiotemporal assembly are essential for centromere propagation. CENP-A synthesis peaks in late G2, while its assembly occurs during late telophase/early G1. ...
Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes [0.03%]
stiffness诱导的成人心肌细胞GLUT4转运障碍
Alexia Vite,Tony Guo,Nesrine Bouhrira et al.
Alexia Vite et al.
Abnormal myocardial fuel utilization contributes to heart failure (HF). Myocardial glucose uptake in response to insulin is suppressed in patients with HF, but the mechanisms of this metabolic inflexibility are not fully understood. The pre...
Addition of blood-stage antibody enhances anti-sporozoite antibody protection in a humanized mouse model of Plasmodium falciparum infection [0.03%]
血阶段抗体的添加可增强抗孢子体抗体在人源化疟原虫鼠模型中的保护作用
Payton Kirtley,Thomas Martinson,Francesca R Donnellan et al.
Payton Kirtley et al.
Malaria continues to exact a high disease burden worldwide, and improved vaccines and therapeutics are desperately needed. Both licensed vaccines target only the circumsporozoite protein (CSP) expressed during early stages of Plasmodium fal...
Divergent toxicity mechanisms of amyloid-beta aggregates arising from a single aggregation reaction [0.03%]
源自单一聚集反应的淀粉样蛋白-β聚集体产生不同的毒性机制
Vanya Metodieva,Sybille Marchese,Pietro Esposito et al.
Vanya Metodieva et al.
Amyloid-β 1-42 (Aβ42) aggregation is among the earliest pathological signs in Alzheimer's disease (AD). Here, we characterized Aβ42 species at several aggregation stages at the single-molecule level and examined their toxicity in murine ...
Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation [0.03%]
Cd99l2调节兴奋性突触发育并抑制早期基因激活
Minji Kang,Sang Ho Yoon,Minkyung Kang et al.
Minji Kang et al.
Published Erratum
Cell reports. 2026 Jun 22;45(7):117625. DOI:10.1016/j.celrep.2026.117625 2026