Phage biocontrol reduces the disease burden and modulates plant immunity through suppression of bacterial virulence [0.03%]
噬菌体生物防治通过抑制细菌致病性来降低疾病负担并调节植物免疫力
Sebastian H Erdrich,Mirco T Keilhammer,Swati Sharma et al.
Sebastian H Erdrich et al.
Bacteriophages are emerging as modulators of plant-microbe interactions and promising biocontrol agents against bacterial plant pathogens. In this study, we investigate the tripartite interaction between Arabidopsis thaliana, Xanthomonas ca...
Structural mechanisms for self-activation of protease-activated receptor 4 by tethered ligand [0.03%]
锚定配体介导的蛋白酶激活受体4自激活的结构机制研究
Zhikang Xu,Jiacheng He,Zihan Zhou et al.
Zhikang Xu et al.
Protease-activated receptor 4 (PAR4) mediates platelet activation during thrombosis and represents a promising target for antiplatelet therapies. This receptor is activated when serine proteases cleave its N terminus, exposing a self-activa...
Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice [0.03%]
抗Aβ寡聚体抗体B28免疫疗法可显著减少APP敲入小鼠的淀粉样蛋白斑块、小胶质细胞增生和记忆衰退
Ting Yang,Yi Ran Xu,Shaomin Li et al.
Ting Yang et al.
Immunotherapy against amyloid β-protein (Aβ) for Alzheimer's disease (AD) has been widely approved. Breakthrough disease-modifying treatments such as lecanemab and donanemab are often followed by drugs with improved efficacy. By immunizin...
TUSC3 serves as a rate-limiting gatekeeper of a glycan-mediated ER triage checkpoint for BMP4/Dpp [0.03%]
TUSC3作为糖基介导的BMP4/Dpp内质网分类检查点的速率限制门控器
Antonio Galeone,Emilio Solazzo,Francesco Lavezzari et al.
Antonio Galeone et al.
Trimming of the three glucose residues decorating nascent N-glycoproteins is a critical step for their entry into the endoplasmic reticulum quality control (ERQC) and recognition by ER chaperones. However, the functional relevance of the se...
Wendy M McKimpson,Nehan Hoque,Matthew Barter et al.
Wendy M McKimpson et al.
A critical driver of type 2 diabetes is the failure of insulin-secreting β cells due to dysfunction and loss of cell number or identity. The signaling pathways that trigger these events remain unclear. Here, we identify an epithelial-to-me...
GABAergic neurons in medial prefrontal cortex and ventral hippocampus encode information about reward history in male mice [0.03%]
雄性小鼠腹侧海马和前额叶皮层的GABA能神经元编码奖励历史信息
Eshaan S Iyer,Vedrana Cvetkovska,Joëlle Lopez et al.
Eshaan S Iyer et al.
Prevailing views of reward encoding focus on excitatory neurons with GABAergic interneurons relegated to a supporting role, overlooking their potential to independently encode information. Here we simultaneously examine reward encoding in G...
Dynamicity of Topoisomerase 1 binding at super-enhancers regulates TLR-responsive gene expression program in macrophages [0.03%]
拓扑异构酶1在超级增强子上的动态结合调节巨噬细胞中TLR响应基因表达程序
Harshdeep Kaur,Vanshika Sood,Pallawi Choubey et al.
Harshdeep Kaur et al.
Toll-like receptor (TLR) activation elicits an effective innate immune response by inducing the expression of primary and secondary response genes (PRGs and SRGs). Topoisomerase 1 (TOP1) has emerged as a critical regulator of innate immune ...
Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites [0.03%]
钙黏蛋白对内质网-细胞膜接触位点的调控作用
Sonam Lhamo,Navaneetha Krishnan Bharathan,William Giang et al.
Sonam Lhamo et al.
The spatial organization and dynamics of the endoplasmic reticulum (ER) govern when and where ER tubules engage with other organelles and the plasma membrane. We previously found that ER tubules are closely associated with desmosomes, but t...
Type I unconventional protein secretion of the SARS-CoV-2 nucleocapsid protein promotes inflammatory cytokine release [0.03%]
SARS-CoV-2核衣壳蛋白一类非经典蛋白质分泌途径促进炎症细胞因子释放
Liwei Zheng,Minghui Li,Weilin Gu et al.
Liwei Zheng et al.
SARS-CoV-2 infection remains a global health threat, yet its pathogenic mechanisms are incompletely understood. Here, we show that viral nucleocapsid protein (NP) is detectable in the serum of patients with SARS-CoV-2 infection independentl...
Fibroblast MrgprX2/B2 signaling drives hypertrophic scar fibrosis [0.03%]
成纤维细胞MrgprX2/B2信号驱动增生性瘢痕形成
Heng Xu,Meiying Sheng,Yuxin Jia et al.
Heng Xu et al.
Hypertrophic scarring (HTS) represents a common clinical challenge characterized by excessive fibroblast activation and tissue fibrosis. However, the upstream signals driving pathological fibroblast proliferation remain poorly understood. H...