APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice [0.03%]
人源性APOE3和APOE4星形胶质细胞在嵌合小鼠中对阿尔茨海默病病理变化和小胶质细胞反应的不同调节作用
Joan Cruz-Sese,Marta Mirón-Alcala,María Alfonso-Triguero et al.
Joan Cruz-Sese et al.
Astrocytes and APOE are strongly implicated in Alzheimer's disease (AD), yet the impact of astrocytes carrying different APOE variants on AD hallmarks remains incompletely understood. Here, we generate a chimeric model of AD by transplantin...
Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC [0.03%]
整合的三维基因组和表观基因组分析确定TP53RK和SYBU在HCC中是维持干细胞特性和抗肿瘤免疫的关键调节因子
Yanmei Yang,Peixian Li,Liangbo Zhao et al.
Yanmei Yang et al.
Three-dimensional (3D) genome organization plays a fundamental role in governing gene regulation and tumor cell properties. However, how higher-order chromatin architecture regulates stemness in hepatocellular carcinoma (HCC) remains unclea...
PKR engages viral RNA and intron-retained host transcripts during poxvirus infection [0.03%]
病毒感染期间PKR结合病毒RNA和保留内含子的宿主转录本
Ruilin Zhang,Xiang Ye,Andrew C Dixson et al.
Ruilin Zhang et al.
Recognition of double-stranded (ds) RNA is central to antiviral defense, yet how RNA sensors are activated during infection remains unclear. Here, we demonstrate that during vaccinia virus (VacV) infection, PKR binding is enriched on viral ...
Recruitment of Cas3 enables DNA cleavage by the type I-A CRISPR-Cas system of Saccharolobus islandicus [0.03%]
Cas3的招募可激活Saccharolobus islandicus I-A型CRISPR-Cas系统DNA切割活性
Suping Jiang,Xuhui Tian,Fang Wang et al.
Suping Jiang et al.
Type I CRISPR-Cas systems constitute the most prevalent prokaryotic adaptive immune pathways and are classified into seven subtypes (I-A to I-G). These antiviral systems typically exploit a Cascade complex for RNA-guided DNA recognition and...
Characterization of functional human-specific regulatory elements in prefrontal cortical cells [0.03%]
人前额皮层细胞中功能性的特有人类调控元件的特征分析
Bufan Jin,Langjian Zhu,Huizhong Chang et al.
Bufan Jin et al.
Published Erratum
Cell reports. 2026 Aug 7;45(8):117847. DOI:10.1016/j.celrep.2026.117847 2026
Hippocampal-cortical coupling dynamics drive system consolidation of remote memory [0.03%]
海马-皮层动态耦合驱动远程记忆的系统巩固
Tao Sheng,Shaoli Wang,Jiaxi Zhang et al.
Tao Sheng et al.
System consolidation transforms temporary hippocampal representation of memory into long-term storage in cortex. The underlying neural substrate, however, remains enigmatic. Here, we tracked the spatiotemporal evolution of hippocampus (HPC)...
Hyodeoxycholic acid suppresses hepatic steatosis in a PPARα-dependent manner via distinct GLP-1- and iNKT cell-mediated pathways [0.03%]
猪去氧胆酸通过不同的GLP-1和iNKT细胞介导的途径以PPARα依赖性方式抑制肝脂肪变性疾病
Eunyoung Lee,Ryo Hatano,Mariko Takami et al.
Eunyoung Lee et al.
Hepatosteatosis is a common metabolic disorder. Bile acids influence hepatosteatosis, immune function, and incretin secretion. However, whether bile acids mediate hepatosteatosis through these immune or endocrine pathways remain unknown. He...
Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A drift, instability, and chromosome missegregation [0.03%]
新的次中着丝粒无法维持DNA甲基化边界，导致CENP-A漂移、不稳定及染色体分离异常
Megan A Mahlke,Angela Enriquez,Lior Lumerman et al.
Megan A Mahlke et al.
Centromere identity is specified by CENP-A, a histone H3 variant that epigenetically defines centromere position. How CENP-A is maintained at one location in rapidly evolving centromeric DNA is unknown. Using single-cell-derived clones of h...
Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons [0.03%]
簇状输入激活齿状回非线性及钙信号转导以支持CA1锥体神经元高效形成位置域
Simone Tasciotti,Daniel Maxim Iascone,Spyridon Chavlis et al.
Simone Tasciotti et al.
How the spatial arrangement of synaptic inputs shapes neuronal feature selectivity remains a fundamental question. Here, we map the three-dimensional distribution of excitatory and inhibitory synapses across the dendritic arbor of CA1 pyram...
Inhibitory TIGIT signaling is dependent on T cell receptor activation [0.03%]
抑制性TIGIT信号传导依赖于T细胞受体活化
William H Zammit,Lucy J Le Maistre,Thomas A E Elliot et al.
William H Zammit et al.
The immune checkpoint receptor T cell immunoreceptor with Ig and ITIM domains (TIGIT) can signal via cytoplasmic motifs to regulate T cell function. The signaling molecules that mediate inhibitory TIGIT signaling and its regulation in T cel...