Chen Miao,Zhen Wang,Jian Lin et al.
Chen Miao et al.
Mitochondrial redox homeostasis is fundamental for cellular function, and its dysregulation is associated with various diseases, including cancer. Isocitrate dehydrogenase 2 (IDH2) is a key enzyme that maintains this balance by generating N...
Impaired brain-gut circuit for gut motility dysfunction in mouse models of Parkinson's disease [0.03%]
帕金森病小鼠模型中胃运动功能障碍的脑肠环路受损
Minhui Yu,Li Zhang,Xianying Zhang et al.
Minhui Yu et al.
Gut motility dysfunction is a common symptom of Parkinson's disease (PD), but its central mechanisms remain unclear. Here, we utilize multiple mouse models, which mimic both genetic and sporadic PD, to reproduce PD-related gut motility dysf...
Phenotypic analysis of productively SIV-infected cells in blood and lymphoid tissues of rhesus macaques [0.03%]
用表型分析检测感染了猴免疫缺陷病毒的恒河猴血细胞和淋巴组织中的受感染细胞
César Trifone,Amélie Pagliuzza,Shilei Ding et al.
César Trifone et al.
Simian immunodeficiency virus (SIV) primarily infects CD4+ T cells, yet the relative contribution of different subsets to viral production in blood and tissues remains unclear. We develop SIV-Flow, a flow cytometry-based assay, to quantify ...
Cohesin release-factor Wapl modulates axis and chromatin structure to promote conjunction and separation of meiotic chromosomes [0.03%]
Wapl通过调节轴结构和染色质结构促进减数分裂染色体连接和分离
Denise Zickler,Ana-Rita Rodrigues Neves,Nancy Kleckner
Denise Zickler
Analysis of meiotic prophase in Sordaria macrospora shows that the cohesin-release factor Wapl is a multi-stage modulator of whole-chromosomal dynamics. Absence of Wapl affects chromosome lengths, but without direct effects on basic recombi...
Circadian rhythms in microglia mediate early life synaptic development in a sex-specific manner [0.03%]
节律性微胶质细胞介导性别特异性的生命早期突触发育
Brandy N Routh,Cecily R Gibson,Celina C Yang et al.
Brandy N Routh et al.
Children today experience widespread circadian disruption from nighttime screen use and irregular sleep, yet how internal clocks shape brain development is unclear. Adolescence is a critical window when synaptic connectivity is refined, in ...
PKA-dependent phosphorylation drives stress granule maturation and controls recovery from prolonged starvation [0.03%]
PKA依赖性磷酸化驱动胁迫颗粒成熟并调控长时间饥饿后的恢复能力
Sonja Kroschwald,Caroline Wilson-Zbinden,Federico Uliana et al.
Sonja Kroschwald et al.
During environmental stress, cells form dynamic biomolecular condensates called stress granules (SGs) that can undergo a maturation process towards more solid-like material states. Deposition of SG proteins in insoluble aggregates is a hall...
Caloric restriction suppresses colorectal tumors and melanoma through CD8 T cells in aged mice [0.03%]
限制卡路里通过CD8 T细胞抑制老年小鼠的结直肠肿瘤和黑色素瘤
Taichi Horino,Haruki Horiguchi,Daisuke Torigoe et al.
Taichi Horino et al.
Caloric restriction (CR) has shown the potential to extend lifespan and reduce cancer risk; however, the mechanisms underlying CR-mediated tumor suppression are not fully understood. Here, we investigate age-dependent CR effects on tumor pr...
Orthogonal cell division mediated by PcdA organizes surface virulence factors to drive staphylococcal abscess community formation [0.03%]
由PcdA介导的正交细胞分裂可组织表面毒力因子以促进金黄色葡萄球菌脓肿群落形成
Félix Ramos-León,Valerie Altouma,Peri Goldberg et al.
Félix Ramos-León et al.
During infection, Staphylococcus aureus forms dense multicellular structures, called staphylococcal abscess communities (SACs) that are encased in a capsule made of host fibrin to evade host immune defenses. S. aureus cells divide character...
From NAD+ metabolism to skeletal muscle function: The emerging role of ADP-ribosylation [0.03%]
从NAD+代谢到骨骼肌功能：ADP-核糖基化的新兴作用
Caio Y Yonamine,Ever Espino-Gonzalez,Sheila P Aguilar Lozano et al.
Caio Y Yonamine et al.
Nicotinamide adenine dinucleotide (NAD+) is a metabolic coenzyme and substrate for enzymes catalyzing post-translational modifications such as ADP-ribosylation. This reversible modification, mediated by ADP-ribosyltransferases and hydrolase...
A proteome-centered atlas links tissue specialization and phytohormone variation in rapeseed [0.03%]
基于蛋白质组的图谱将组织专业化与油菜植物激素变异联系起来
Zhuo Chen,Zhiyang Hou,Xingzhi Qian et al.
Zhuo Chen et al.
Rapeseed is a globally important oil crop cultivated worldwide, but its proteome remains uncharacterized. Here, we established a quantitative atlas of the proteome and phosphoproteome spanning 24 major tissues. Using Orbitrap Astral MS inst...