Human adenovirus protein VII inhibits type I IFN production by antagonizing viral RNA sensor RIG-I [0.03%]
人腺病毒蛋白VII通过拮抗病毒RNA传感器RIG-I抑制I型干扰素产生
Pei-Hong Yu,Li-Min Zhang,Qian Gu et al.
Pei-Hong Yu et al.
The genomes of human adenoviruses (HAdVs) are double-stranded DNA bound with viral nucleocapsid protein VII. During HAdV infection, host RNA polymerase can produce viral-associated RNAs (VA RNAs) that are recognized by retinoic acid-inducib...
PUMILIO proteins maintain lineage balance via post-transcriptional repression of germline fate and promotion of somatic differentiation [0.03%]
PUMilio蛋白通过转录后抑制生殖细胞命运和促进体细胞分化来维持谱系平衡
Ting Lu,Yiying Yang,Xiajun Li et al.
Ting Lu et al.
Loss of the RNA-binding proteins PUM1 and PUM2 leads to gastrulation failure and embryonic lethality, but the mechanisms underlying this phenotype remain unclear. Using embryoid bodies as an in vitro model of early embryogenesis, we show th...
The SepN-FraD structural module serves as an anchor and assembly platform for septal junctions in cyanobacteria [0.03%]
肽聚糖合成酶SepN和跨膜结构域蛋白FraD构建的复合物是蓝藻分裂隔膜形成的分子基础
Ann-Katrin Kieninger,Yanxun Li,Ana Janović et al.
Ann-Katrin Kieninger et al.
Intercellular communication is essential for multicellularity. In filamentous cyanobacteria such as Nostoc sp. PCC 7120, communication occurs through septal junctions (SJs) that traverse the septum and connect neighboring cells. Although th...
Thyroid hormone activation drives fibroblast identity and tumor remodeling in cutaneous squamous cell carcinoma [0.03%]
甲状腺激素活化驱动皮肤鳞状细胞癌成纤维细胞身份和肿瘤重塑
Emery Di Cicco,Caterina Miro,Annarita Nappi et al.
Emery Di Cicco et al.
Cutaneous squamous cell carcinoma is a major cause of cancer-related mortality. Although immune checkpoint blockade improves outcomes, many patients fail to respond or develop resistance. Cancer-associated fibroblasts (CAFs) promote tumor p...
A maternal Polycomb imprint is maintained in early Drosophila development through lower-order methylation states [0.03%]
低阶甲基化在早期果蝇发育中维持母源性多梳染色质印记
Eleanor A Degen,Natalie Gonzaga-Saavedra,Shelby A Blythe
Eleanor A Degen
Polycomb group (PcG) proteins regulate embryonic epigenetic states by facilitating mono-, di-, and tri-methylation of H3 lysine 27 (H3K27me1/2/3). For the zygote to inherit a maternal H3K27 methylation state, PcG modifications established d...
Double-ring assembly of mpox virus I3L reveals an unconventional mechanism for ssDNA engagement [0.03%]
双环组装揭示了痘苗病毒I3L与单链DNA结合的非常规机制
Kankan Yang,Mengrui Ge,Jinmiao Song et al.
Kankan Yang et al.
Poxviruses, including variola and mpox virus (MPXV), are large dsDNA viruses that replicate their genomes in the host cytoplasm via virally encoded proteins. The single-stranded DNA-binding protein (SSB) I3L is an essential component of thi...
Zhijie Gu,Xiaojuan Guo,Wenxuan Xu et al.
Zhijie Gu et al.
Barrier tissues-including the skin, respiratory tract, and gastrointestinal tract-are dynamic interfaces where neural and immune systems converge to coordinate barrier defense, inflammation, and repair. Recent studies show that neurons and ...
Yixin Sun,Zhizhuo Chen,Mengdi Zhang et al.
Yixin Sun et al.
Abnormal wound healing leads to pathological scar formation, characterized by excessive fibrosis. Despite their clinical relevance, the underlying molecular factors remain poorly understood. Using single-cell RNA sequencing, we identify FOS...
Yeast Rpd3L histone deacetylase couples nutrient shifts to genome-wide chromatin reprogramming [0.03%]
酿酒酵母Rpd3L脱乙酰酶通过连接营养转换与全基因组染色质重组来调控细胞分化和发育
Saikat Bhattacharya,Benjamin M Sutter,Benjamin P Tu
Saikat Bhattacharya
Adaptive transcriptional rewiring underlies the metabolic flexibility of Saccharomyces cerevisiae. We demonstrate that the histone deacetylase Rpd3 mediates nutrient-dependent chromatin reprogramming that coordinates transcriptional shutdow...
A telomerase-SUCLG2 signaling axis drives drug resistance by protecting persister cells [0.03%]
端粒酶-SUCLG2信号轴通过保护休眠细胞诱导耐药性
Yu Liu,Kejia Zhao,Binbin Hu et al.
Yu Liu et al.
The evolution of drug-tolerant persister (DTP) cells into resistant clones remains a major clinical obstacle to targeted therapies. Transcriptomic profiling across melanoma (A375, SK-MEL-28), non-small cell lung cancer (NSCLC; HCC827, PC-9)...