Aortic valve stenosis serum IGFBP2 mediates female-specific Evogliptin resistance in valve myofibroblasts [0.03%]
主动脉瓣狭窄患者血清IGFBP2介导Evogliptin在女性特异的瓣膜肌成纤维细胞中的耐药性
Brandon J Vogt,Megan Chavez,Nicole E Félix Vélez et al.
Brandon J Vogt et al.
Aortic valve stenosis (AVS) is a sexually dimorphic cardiovascular disease characterized by fibro-calcification of the aortic valve leaflet. Sex differences in AVS arise in part from sexually dimorphic serum composition that differentially ...
Endothelial FGF13 impairs angiogenesis by accelerating oxygen-independent HIF-1α degradation [0.03%]
内皮FGF13通过加速氧气非依赖性HIF-1α降解而抑制血管生成
Zhaohang Wu,Yingyun Chen,Zhouhao Tang et al.
Zhaohang Wu et al.
Angiogenesis is a tightly regulated process essential for both development and disease, yet the role of fibroblast growth factor 13 (FGF13) in vascular remodeling has remained unclear. Here, we identify FGF13 as a key negative regulator of ...
Dpb11 facilitates the colocalization of Mec1-Ddc2 with its activators on gapped DNA [0.03%]
DPB11促进MEC1-DDC2与缺口DNA上的激活物共定位
Emily C Beckwitt,Gabriella N L Chua,Shixin Liu et al.
Emily C Beckwitt et al.
The eukaryotic DNA damage and replication stress checkpoint is initiated by activation of the apical kinase complex ATR-ATRIP on RPA-coated ssDNA. In Saccharomyces cerevisiae, the Mec1-Ddc2 (hATR-ATRIP) activator and checkpoint mediator Dpb...
Graph-based analysis of volumetric image data reveals predominant layer Va-to-II/III feedback in mouse motor cortex [0.03%]
基于图形的体积图像数据分析揭示了小鼠运动皮层中Va层到II / III层的反馈占优势
Philippe Aymard,Juan Carlos Boffi,Thibault Lagache et al.
Philippe Aymard et al.
How precise 3D interactions among cortical neurons underlie layer-specific computations remains elusive. We develop a graph-framework to infer functional connectivity from fast volumetric two-photon Ca2+ imaging of spontaneous activity in t...
Orb2 RNA-binding activity promotes neural stem cell development and brain growth in Drosophila larvae [0.03%]
orb2的RNA结合活性能够促进果蝇幼虫神经干细胞发育及大脑生长
Taylor Hailstock,Joseph Buehler,Beverly V Robinson et al.
Taylor Hailstock et al.
Neurodevelopment requires precise translational control, the disruption of which is implicated in neurological disorders, developmental delays, and microcephaly. We identify a role for the Drosophila CPEB-family protein Orb2, a translationa...
DDIT3, OTUB2, and ASS1 regulate arginine biosynthesis in colorectal cancer cells under arginine deficiency [0.03%]
DDIT3、OTUB2和ASS1在精氨酸缺乏的结直肠癌细胞中调节精氨酸生物合成
Mengying Li,Jie Zhang,Hui Zhang et al.
Mengying Li et al.
Argininosuccinate synthetase 1 (ASS1) is a rate-limiting enzyme in arginine biosynthesis, and its stability is regulated by TRAF2-mediated ubiquitination. Here, we report OTUB2 as a major deubiquitinase to stabilize ASS1, resulting increase...
ER-mitochondria contacts and mitochondrial fusion correlate with increased mitochondrial activity during vertebrate embryogenesis [0.03%]
脊椎动物胚胎发生过程中线粒体活性增加与内质网-线粒体接触和线粒体融合相关
Anastasia Chugunova,Isabelle Schütz,Hannah Keresztes et al.
Anastasia Chugunova et al.
Increased mitochondrial activity is essential for embryo development. Although conserved across organisms, the molecular basis of this increase is unknown, as detailed biochemical analysis in vertebrates is hampered by the limited availabil...
Constitutive DUSP2 expression enhances lymphoid cell proliferation by activating CDK1 and promotes lymphomagenesis [0.03%]
组成型DUSP2表达通过激活CDK1增强淋巴细胞增殖并促进淋巴瘤发生
Yu Qian,Jutatip Panaampon,Bjoern Chapuy et al.
Yu Qian et al.
DUSP2 is known as a nuclear dual-specificity phosphatase, highly restricted to immune cells. Its expression is induced by antigenic and mitogenic stimuli and has been implicated in immune cell differentiation and functions. However, its rol...
ERK1/2 function as a central hub safeguarding primed human embryonic stem cell identity via multifaceted regulatory networks [0.03%]
ERK1/2通过多层面调控网络担任中心节点确保类原始态人胚胎干细胞身份稳定
Yifan Zhou,Hanzhi Zhao,Min Shao et al.
Yifan Zhou et al.
ERK1/2 play crucial roles in diverse cellular processes, yet their functions and underlying mechanisms in human embryonic stem cells (hESCs) remain incompletely defined. Here, we generate hESC lines with graded ERK1/2 activities and demonst...
Myeloid MMP14 couples extracellular proteolysis to inflammatory and metabolic remodeling during obesity [0.03%]
肥胖期间髓系MMP14介导的细胞外基质蛋白酶解调控炎症及代谢重塑
Long J Shao,Fathima Elizondo,Feng Gao et al.
Long J Shao et al.
Macrophages orchestrate tissue remodeling, inflammation, and metabolic dysfunction in obesity, but the role of macrophage-intrinsic extracellular proteolysis in immunometabolic regulation remains unclear. Matrix metalloproteinase-14 (MMP14)...