Katherine A Boden,Tafadzwa T J Kufazvinei,Jason Chai et al.
Katherine A Boden et al.
"Trained immunity" describes long-term functional reprogramming of innate immune cells that enhances responses to secondary challenge. However, the extent to which diverse training stimuli converge on shared transcriptional programs remains...
YAP1 lactylation confers cisplatin resistance and prognostic value by suppressing ferroptosis via FOSL1 in bladder cancer [0.03%]
YAP1乳化修饰通过FOSL1抑制铁死亡从而赋予膀胱癌耐药及预后价值
Zheyu Ai,Hao Zhou,Lijuan Jiang et al.
Zheyu Ai et al.
Resistance to cisplatin-based chemotherapy remains a major barrier to effective systemic treatment of bladder cancer, underscoring the need for predictive biomarkers and therapeutic targets. Here, we identify YAP1-K90la as a functional post...
Regulation of neutrophil homeostasis by the TNFAIP8 family of polarity proteins [0.03%]
TNFAIP8家族极性蛋白对中性粒细胞稳态的调节作用
Han Wang,Wei Lu,Lu Zhang et al.
Han Wang et al.
The extremely short life span of neutrophils is critical for immune homeostasis and immune defense against pathogens, but the molecular mechanisms underlying this phenomenon are not fully understood. Here we report that TNFAIP8 (TNF-α-indu...
TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation [0.03%]
TGFβ通过调节间充质凝聚决定上皮组织间距
Chan Jin Park,Pengfei Zhang,Carolina Trenado-Yuste et al.
Chan Jin Park et al.
The branched structure of the vertebrate lung provides a high surface area-to-volume ratio that enhances diffusion-driven gas exchange. Generating this structure requires that epithelial branches avoid contacting one another during developm...
Conserved anterior/posterior tissue asymmetry encodes proximal/distal positional information during axolotl limb regeneration [0.03%]
在墨西哥钝口螈肢体再生过程中保守的前后组织不对称性编码近端/远端位置信息
Alexander J Trostle,Matthew A Cherubino,Dimitri Sokolowskei et al.
Alexander J Trostle et al.
While mammalian limb regeneration is limited to the distal fingertips, axolotls can regenerate entire limbs, providing a model system to uncover conserved patterning mechanisms. Although anterior-posterior (A/P) signaling is required for li...
Sustained AMPAR expression in CA3 neurons may mediate neuroprotection following FLASH-RT [0.03%]
CA3神经元中AMPAR的持续表达可能介导了FLASH放射治疗后的神经保护作用
Louis V Kunz,Aymeric Almeida,Michèle Knol et al.
Louis V Kunz et al.
To elucidate the early mechanisms underlying the long-term neuroprotective effect of FLASH-RT in the normal brain, spatial transcriptomics (Nanostring) were performed after whole-brain irradiation of C57BL/6J mice with either 1 or 3 fractio...
eIF4E2 deficiency translationally unleashes WRN to sustain DNA repair-mediated chemoresistance [0.03%]
eIF4E2缺失通过翻译激活WRN维持DNA修复介导的化学抗性
Xianrong Lin,Rui Zhang,Wenjun Tao et al.
Xianrong Lin et al.
Therapeutic resistance to DNA-damaging agents (DDAs) remains a primary obstacle in non-small cell lung cancer (NSCLC) treatment. Through multi-level analyses of clinical cohorts, cell lines, and derived resistant models, we identify eIF4E2 ...
Tanycyte BMAL1 regulates high-fat diet weight gain and shapes arcuate neurogenesis in female mice [0.03%]
雌性小鼠脂肪摄食诱导的下丘脑tanycytes BMAL1调节体重增加和弓状核神经发生
Daniel Maxim Iascone,Pavel Pivarshev,Jianing Yang et al.
Daniel Maxim Iascone et al.
The hypothalamic radial-glia-like tanycyte population plays important and intertwined roles in metabolism, reproduction, and seasonality. Although these processes are circadian-regulated, the role of the molecular clock in tanycytes themsel...
Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab [0.03%]
甲基甘油醛清除剂可使KRAS突变的结直肠肿瘤重新对西妥昔单抗敏感
Justine Bellier,Marie-Julie Nokin,Maurine Caprasse et al.
Justine Bellier et al.
Published Erratum
Cell reports. 2026 Jul 13;45(7):117715. DOI:10.1016/j.celrep.2026.117715 2026
Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology [0.03%]
内侧回虫海马同步化与阿尔茨海默病病理模型小鼠记忆障碍发生的平行关系
Lauren M Vetere,Angelina M Galas,Nick Vaughan et al.
Lauren M Vetere et al.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive impairments in episodic and spatial memory, as well as circuit and network-level dysfunction. While functional impairments in medial entorhinal cortex (MEC...