TTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence [0.03%]
TTYH3调节溶酶体氯离子电导并控制溶酶体融合、自噬和衰老
Jiamin Huang,Yayu Wang,Yudong Xu et al.
Jiamin Huang et al.
Chloride is the most abundant anion within lysosomes and plays a pivotal role in regulating lysosomal physiology and function. However, the mechanisms governing lysosomal chloride homeostasis remain largely elusive. Here, we identified TTYH...
PRKCI-ECT2 copy number gain promotes developmental reprogramming and metastatic competence in lung adenocarcinoma [0.03%]
PRKCI-ECT2拷贝数增加促进肺腺癌的发育重编程和转移能力
Duy T Nguyen,Kayleah M Meneses,Cheng Zhang et al.
Duy T Nguyen et al.
Lung adenocarcinoma (LUAD) shows extensive lineage plasticity and early metastatic dissemination, but the oncogenic events that actively drive these processes remain poorly defined. Here, we identify coordinated PRKCI and ECT2 copy number g...
Ethylene-REF6 regulatory module enables endophyte-mediated thermotolerance of plant growth and reproduction [0.03%]
乙烯-REF6调控模块可使内生菌介导的植物生长和繁殖耐热性增强
Anam Fatima,Kirti Shekhawat,Louai Alidrissi et al.
Anam Fatima et al.
Global warming affects plant growth and yield, posing a major threat to global food security. Male sexual reproduction is the most sensitive stage for plant yield under elevated temperature (eT). We show here that under eT conditions, plant...
Teresa Spanò,Belquis Nassim-Assir,Eva Kaulich et al.
Teresa Spanò et al.
Cortical layer 1 plays an essential role in neural networks, integrating many streams of information and undergoing plasticity during learning. Yet, we know little about the underlying molecular processes and whether layer-specific adaptati...
N-terminally modified GLP1R agonists drive G protein bias via extracellular loop 3 displacement [0.03%]
通过外部环3置换偏向G蛋白的N端修饰GLP1R激动剂
Li-Hua Zhao,Qian He,Qingning Yuan et al.
Li-Hua Zhao et al.
The glucagon-like peptide-1 receptor (GLP1R), a class B G protein-coupled receptor (GPCR), is a pivotal therapeutic target for type 2 diabetes mellitus and obesity. GLP1R agonists signal through both G protein and β-arrestin pathways, asso...
CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair [0.03%]
CD34+KLF4+间充质干细胞参与子宫内膜再生修复
Mingzhu Yin,Huanjiao Jenny Zhou,Caixia Lin et al.
Mingzhu Yin et al.
Published Erratum
Cell reports. 2026 Jul 17;45(7):117759. DOI:10.1016/j.celrep.2026.117759 2026
A receptor-centered approach identifies Lom as a LamB-bound superinfection exclusion factor in bacteriophage λ [0.03%]
基于受体的方法鉴定Lom为λ噬菌体的LamB结合型超级感染排除因子
Xiaofei Ge,Zhiwei Gu,Jiawei Wang
Xiaofei Ge
Bacteriophages face intense competition within bacterial populations. Although bacteria encode diverse anti-phage mechanisms, strategies protecting virions at the host surface remain poorly understood. Here, we develop a receptor-centered d...
Deep learning reveals FLAD1-mediated mitochondrial metabolic reprogramming in hypoxic tumors [0.03%]
深度学习揭示缺氧肿瘤中FLAD1介导的线粒体代谢重编程
Xiangyu Zhao,Tao Wu,Sanan Wu et al.
Xiangyu Zhao et al.
Hypoxia, a hallmark of solid tumors, drives malignant progression and represents a major therapeutic challenge. Metabolic reprogramming induced by hypoxia creates unique metabolic vulnerabilities that can be exploited therapeutically. Here,...
ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer [0.03%]
ABL激酶失活可诱发转录-复制冲突并损害小细胞肺癌转移灶中叉的进展
Jing Jin Gu,Kevin M Scott,Arijit Ghosh et al.
Jing Jin Gu et al.
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine cancer that is typically metastatic upon diagnosis and has poor overall survival. Here we report that the inactivation of ABL tyrosine kinases impairs the outgrowth of meta...
Replication-uncoupled MET1/DNMT1 activity shapes inheritance of DNA methylation [0.03%]
独立于复制的MET1/DNMT1活性塑造了DNA甲基化的遗传性态
Alejandro Edera,Marion Larue,Basile Leduque et al.
Alejandro Edera et al.
Cytosine methylation at CG sites is proposed to be maintained during DNA replication through a semiconservative mechanism. In mammals, this maintenance involves replication-coupled and replication-uncoupled steps; however, the underlying me...