p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma [0.03%]
p57通过促进cGAS-STING介导的先天性感知增加肝细胞癌免疫治疗的疗效
Shirong Zhang,Mengjie Liu,Deli Tan et al.
Shirong Zhang et al.
Hyperactivation of the cell cycle in cancer cells suppresses antitumor immunity. The endogenous cyclin-dependent kinase inhibitor p57 is an important tumor suppressor and a potential therapeutic target for hepatocellular carcinoma (HCC). Ho...
Low-input proteomics identifies vWF as a negative regulator of Tet2 mutant hematopoietic stem cell expansion [0.03%]
低投入蛋白质组学鉴定vWF为Tet2突变造血干细胞扩增的负调节因子
Maria Jassinskaja,Daniel Bode,Monika Gonka et al.
Maria Jassinskaja et al.
Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), few studies exist at the protein level. We perform a deep, multi-omics characterization (epigenome, transcriptome, and proteom...
Emergence of high-metastatic potentials and prediction of recurrence and metastasis [0.03%]
高转移潜能的产生及复发和转移的预测模型
Aravind Srinivasan,Arwen Conod,Yann Tapponnier et al.
Aravind Srinivasan et al.
What makes a cancer highly metastatic is not known. Here, we inquire on the metastatic potential (MP) of tumor cells, which reflects their probability to emigrate from the primary tumor to new sites to form secondary cancers. We determine t...
Differential translocation of bacteriophages across the intestinal barrier in health and Crohn's disease [0.03%]
肠道健康和克罗恩病状态下噬菌体跨肠屏障转运的差异性
Clara Douadi,Quentin Lamy-Besnier,Ilias Theodorou et al.
Clara Douadi et al.
Impaired intestinal barrier function is a major feature of Crohn's disease, leading to exacerbated inflammation in response to the microbiota. In this context, the translocation of intestinal bacteriophages (phages) and their effects on the...
Activated T cells degrade extracellular proteins to enhance effector functions [0.03%]
激活的T细胞降解胞外蛋白以增强效应功能
Yunxue Yin,Xiaorong Lin,Linlin Li et al.
Yunxue Yin et al.
Proteins are the most abundant source of amino acids in body fluids. However, the potential contribution of extracellular protein catabolism to the regulation of T cell immunity remains poorly understood. In this study, we show that endocyt...
CELL DEATH1 safeguards microspore fate determination by repressing vacuole-executed programmed cell death [0.03%]
细胞死亡1通过抑制液泡执行的程序性细胞死亡来保护小孢子命运决定
Yiming Wang,Yixuan Feng,Tengwei Yu et al.
Yiming Wang et al.
During flowering plant reproduction, microspores develop a prominent vacuole before entering pollen mitosis I (PMI), a critical checkpoint where defective microspores are selectively eliminated via programmed cell death (PCD). However, the ...
Yu-Hao Gao,Yi-Zhe Huang,Zhao-Xing Li et al.
Yu-Hao Gao et al.
TRPV1, a member of the transient receptor potential vanilloid subfamily, mediates nociception and thermoregulation. TRPV1-targeting analgesics frequently induce hyperthermia, underscoring the need for structural insights to guide the develo...
Haifeng Ye,Qing Yu,Alvin John Kim Seong Lee et al.
Haifeng Ye et al.
Optimal tissue recovery requires coordinated fibroblast activity from deep fascia. Using multi-modal imaging of fascia explants from lineage-specific reporter mice, we tracked wound fibroblasts over 5 days, revealing their organization into...
Immunopeptidomics combined with full-length transcriptomics uncovers diverse neoantigens [0.03%]
免疫肽组学与全长转录组学结合发现多样性的新抗原
Takamasa Ishino,Tomofumi Watanabe,Serina Tokita et al.
Takamasa Ishino et al.
Neoantigens are crucial for antitumor immunity and immune checkpoint inhibitor (ICI) efficacy by triggering strong immune responses. However, conventional methods for identifying neoantigens, such as whole-exon sequencing and short-read RNA...
Interleukin 4 selectively expands functional type 1 conventional dendritic cells from bone marrow progenitors [0.03%]
干扰素-4选择性地从骨髓祖细胞扩增功能正常的I型常规树突状细胞
Mitra Ashayeripanah,Hannah Coughlan,Shengbo Zhang et al.
Mitra Ashayeripanah et al.
Type 1 conventional dendritic cells (cDC1s) are infrequent immune cells with an essential role in orchestrating immune responses to malignancies or infections. Despite their significance in regulating adaptive immunity, the absence of effic...