The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair [0.03%]
FANCD2-FANCI异二聚体在DNA双链断裂修复过程中协调染色质开放性和细胞周期进程
Christine M Joyce,Julien Bacal,Soham P Chowdhury et al.
Christine M Joyce et al.
The FANCD2-FANCI heterodimer contributes to DNA repair at interstrand crosslinks and sites of replication stress. This complex has been physically and mechanistically linked to double-strand break (DSB) repair, but its role in that process ...
Shivani Baisiwala,Elisa Fazzari,Matthew X Li et al.
Shivani Baisiwala et al.
A major obstacle to identifying effective therapies for the aggressive brain tumor glioblastoma is the lack of human-specific, immunocompetent models that reflect the human tumor microenvironment. To address this, we developed the immune-hu...
DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling [0.03%]
DNA-PKcs通过调节LAT依赖性信号控制针对癌症和移植同种异体移植物的细胞毒性T细胞反应
Randall R Rainwater,Ana C Azevedo-Pouly,Zachary J Waldrip et al.
Randall R Rainwater et al.
Formation of the immune synapse (IS) following T cell antigen recognition includes recruitment of the linker for activation of T cells (LAT). Once at the IS, LAT tyrosines are phosphorylated, allowing it to serve as a scaffold for the forma...
Cell-type-selective synaptogenesis during the development of layer 6 corticothalamic neuron connectivity in the mammalian neocortex [0.03%]
哺乳动物新皮层第6层丘脑皮质神经元连接发育过程中的突触发生细胞类型选择性
Alan Y Gutman-Wei,Sriram Sudarsanam,Alec G Cabalinan et al.
Alan Y Gutman-Wei et al.
The function of the mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 corticothalamic neurons (L6CThNs), ul...
Human liver cholangiocyte organoids capture the heterogeneity of in vivo liver ductal epithelium [0.03%]
人体肝胆管细胞器官芯片捕获体内肝导管上皮异质性
Javier Bregante,Flaminia Kaluthantrige Don,Fabian Rost et al.
Javier Bregante et al.
Human liver ductal epithelium is morphologically, functionally, and transcriptionally heterogeneous. Understanding the impact of this heterogeneity has been challenging due to the absence of systems that recapitulate this heterogeneity in v...
Temporal orchestration of PRRs fine-tunes circadian pacing and anticipates environmental cues [0.03%]
模式识别受体的时空编排微调昼夜节律并预测环境信号
Mingming Liu,Yujie Liu,Shiqi Gao et al.
Mingming Liu et al.
The five pseudo-response regulators (PRRs) in Arabidopsis are key transcriptional repressors in regulating the circadian clock, yet the mechanisms by which they cooperate to maintain circadian homeostasis and adapt to environmental changes ...
Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice [0.03%]
牙龈卟啉单胞菌诱导遗传抗性小鼠关节炎发病中黏膜固有免疫的启动作用
Yuichi Maeda,Miriam Rabenow,Wei Xiang et al.
Yuichi Maeda et al.
An altered gut microbiota, particularly the expansion of Prevotellaceae members, is implicated in the pathogenesis of rheumatoid arthritis (RA), yet the mechanisms behind this phenomenon remain unclear. Here, we demonstrate that Palleniella...
Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions [0.03%]
嵌合脑模型研究人类星形胶质细胞-神经元和大胶质细胞-小胶质细胞相互作用
Mengmeng Jin,Ziyuan Ma,Haiwei Zhang et al.
Mengmeng Jin et al.
Chimeric brain models generated by transplanting human pluripotent stem cell (hPSC)-derived neural cells are valuable for studying the development and function of human neural cells in vivo. To explore glial-neuronal and glial-glial interac...
Joséphine Groslambert,Sara C Buch-Larsen,Ivo A Hendriks et al.
Joséphine Groslambert et al.
ADP-ribosylation (ADPr) is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteostasis. While the roles of ADPr transferases such as PARP1/2 and TNKS1/2 are well establishe...
METTL3 regulates α-KG-dependent mitophagy and apoptosis in nucleus pulposus cells through the MALAT1/miR-23c/IDH1 axis [0.03%]
METTL3通过MALAT1/miR-23c/IDH1轴调控α-KG依赖的细胞质核糖核酸甲基转移酶3调节细胞质核盘素细胞自噬和凋亡
Ouqiang Wu,Yuxin Jin,Shoutao Weng et al.
Ouqiang Wu et al.
Alpha-ketoglutarate (α-KG), a key intermediate in the tricarboxylic acid (TCA) cycle, was found to be significantly decreased in nucleus pulposus (NP) tissues of patients with intervertebral disc degeneration (IVDD). Supplementation with ...