Discordant neoplasms in monozygotic twins with a germline RECQL5 variant [0.03%]
携带RECQL5种系变异的单卵双生子中的异质性新生物病变
Ammar Husami,Aaron Mochizuki,Qiaoning Guan et al.
Ammar Husami et al.
RECQL5 is a member of the RecQ helicase family involved in DNA replication, homologous recombination, and maintenance of genomic stability. While germline pathogenic variants in other RecQ helicases cause established cancer predisposition s...
Concurrent chemoradiotherapy with or without simultaneous integrated boost for unresectable stage III non-small-cell lung cancer: a randomized phase II trial with exploratory EGFR and PD-L1 analyses [0.03%]
不可切除的三期非小细胞肺癌同步化学放疗联合或不联合同期 boost 放疗：一项随机Ⅱ期临床试验及 EGFR 和 PD-L1 探索性分析
Chengxin Liu,Guanghui Yang,Zhongtang Wang et al.
Chengxin Liu et al.
Background and purpose: Based on the assumption that radiation dose escalation to the primary tumor improves local control and therefore produces survival benefits under the condition of limiting the dose to the organ at ...
Retraction notice to "Ultra-sensitive detection of melanoma NRAS mutant ctDNA based on programmable endonucleases" [Cancer Genetics 294-295 (2025) 47-56] [0.03%]
撤销《基于可编程核酸内切酶的超灵敏黑色素瘤NRAS突变ctDNA检测》(刊载于《癌症遗传学》第294-295期(2025)页47-56)[D]的通知
Zuoying Zhang,Qing Ji,Zhanfang Zhang et al.
Zuoying Zhang et al.
Germline pathogenic PTEN variant in a patient with a Kaposiform haemangioendothelioma [0.03%]
PTEN基因胚系致病突变与进行性卡波西形血管内皮瘤综合征关系的研究进展
Hannah Massey,Karim El Shakankery,Stefan N Symeonides et al.
Hannah Massey et al.
Background/objectives: Kaposiform haemangioendothelioma (KHE) is a rare vascular neoplasm usually presenting in childhood. Its high morbidity and mortality is secondary to compression, invasion, and coagulopathy. The path...
Evolution of germline testing, mutation spectrum and clinico-pathological features in male breast cancer: a 27-year retrospective cohort including 69 patients [0.03%]
男性乳腺癌生殖系检测、突变谱和临床病理特征的演变:包括69名患者27年的回顾队列研究
Nicolas Taris,Nile Duflos De Saint Amand,Carole Hild et al.
Nicolas Taris et al.
Background: Male breast cancer (MBC) is rare, and its genetic basis remains poorly characterized. Over the past few decades, genetic screening strategies have evolved from analyses focusing solely on the BRCA1/2 genes to ...
Regression-based clustered CpG methylome profiling reveals divergent epigenetic trajectories in paired primary and recurrent hepatocellular carcinoma [0.03%]
基于回归的簇状CpG甲基组谱分析揭示了配对原发和复发肝细胞癌中不同的表观遗传轨迹
Yong-Kook Kang,Jung Sun Park,Tae-Seok Kim et al.
Yong-Kook Kang et al.
Recurrent hepatocellular carcinoma (HCC) can arise with variable molecular similarity to the primary tumor, but practical approaches for quantifying methylome divergence in paired tumors remain limited. We performed reduced representation b...
Multi-omics analysis identifies altered EOMES-associated differentiation programs of precursor effector-memory CD8⁺ T cells in transplant-associated cutaneous squamous cell carcinoma [0.03%]
多组学分析鉴定移植相关皮肤鳞状细胞癌中效应记忆前体CD8⁺T细胞EOMES相关分化程序改变
Yanxu Chen,Tianrui Wen,Weijian Nie et al.
Yanxu Chen et al.
Background: Transplant-associated cutaneous squamous cell carcinoma (TSCC) is one of the most common malignancies in solid organ transplant recipients and is strongly associated with long-term immunosuppression. However, ...
Clinical utility and implementation of a virtual molecular tumor board in real-world oncology practice [0.03%]
虚拟分子肿瘤委员会在真实世界肿瘤实践中的实用性和实施情况研究
Olesya Kuznetsova,Maria Cheporova,Madina Khagazheeva et al.
Olesya Kuznetsova et al.
Purpose: To evaluate a decentralized virtual Molecular Tumor Board (MTB) model in routine oncology practice in Russia. Methods: This re...
Integrative transcriptomic and CRISPR dependency analysis identifies hepatoblastoma-specific essential genes and actionable vulnerabilities [0.03%]
整合转录组和CRISPR依赖性分析识别肝母细胞瘤特异性靶点及药物作用弱点
Christophe Desterke,Ana Jarén,Raquel Francés et al.
Christophe Desterke et al.
Background: Hepatoblastoma (HB) is the most common primary liver malignancy in childhood, yet its molecular determinants, functional dependencies, and therapeutic vulnerabilities remain incompletely characterized. Integra...