Influence of lynch syndrome on the incidence of side effects to antineoplastic treatment of patients with colorectal cancer [0.03%]
林奇综合征对结直肠癌患者抗肿瘤治疗不良反应发生率的影响
Ana Valeria Silva Alencar,Giulianna Aparecida Vieira Barreto,Maria Cláudia Dos Santos Luciano et al.
Ana Valeria Silva Alencar et al.
To analyze the influence of Lynch Syndrome on the incidence of adverse reactions to antineoplastic treatment in patients with colorectal cancer. Observational and retrospective study based on analyzing electronic medical records of patients...
Identification of novel gene fusions in high-grade serous ovarian carcinoma: implications for tumorigenesis and targeted therapy [0.03%]
新型基因融合在高级别浆液性卵巢癌中的鉴定：对肿瘤发生及靶向治疗的启示
Katsuhiro Masago,Eiichi Sasaki,Yasuko Fujita et al.
Katsuhiro Masago et al.
Background: High-grade serous ovarian carcinoma (HGSOC) accounts for 70% of all ovarian cancer cases and 80% of related deaths. TP53 mutations are common; however, other driving genetic factors are not well understood. In...
Comparison of somatic variant oncogenicity classification using ClinGen/CGC/VICC guidelines and QIAGEN Clinical Insight Interpret decision support software [0.03%]
ClinGen/CGC/VICC指南与QIAGEN临床洞察解释决策支持软件的肿瘤基因组学分类比较研究
Aarthi Goverdhan,Lisa Mullineaux,Amber Pryzbylski et al.
Aarthi Goverdhan et al.
Accurate clinical interpretation of somatic cancer variants is critical for diagnosis and guidance of precision oncology treatment. As the depth and breadth of genomic sequencing increased, laboratories developed independent standards for t...
Galectin-9 promotes colon cancer development by polarizing macrophages toward the M2 phenotype [0.03%]
半乳糖凝集素9通过使巨噬细胞向M2表型极化来促进结肠癌的发展
Jun Zhang,Yang Xu,Xiao Han et al.
Jun Zhang et al.
Galectin-9 plays multiple roles in various tumors and exerts immune regulation within the tumor microenvironment. It is closely associated with tumor prognosis. This study aimed to analyze the expression of galectin-9 in the colon tumor mic...
Differential impact of IDH1/2 mutations on outcome in adult acute myeloid leukemia patients [0.03%]
IDH1/2突变对成人急性髓系白血病患者预后影响不同
Wanfang Yang,Jing Xu,Shuhua Cao et al.
Wanfang Yang et al.
Mutations in Isocitrate Dehydrogenase-1 (IDH1) and IDH2 lead to abnormal histone hypermethylation and DNA modifications, disrupting cell differentiation, yet the clinical and prognostic significance of these mutations in primary acute myelo...
Molecular mechanisms underlying the oncogenic and tumor-suppressive roles of ZHX2 in cancers [0.03%]
ZHX2在癌症中的致癌和抑癌作用的分子机制研究
Yifan Wei,Haiyang Guo,Jingjie Zhou et al.
Yifan Wei et al.
The transcription factor ZHX2 exerts paradoxical roles in cancer, acting as either an oncogene or tumor suppressor in a context-dependent manner. This duality stems from ZHX2's regulation of key processes including cell cycle, apoptosis, EM...
The multidimensional role of laminin γ2 (LAMC2) on cancer progression [0.03%]
层粘连蛋白γ2(LAMC2)在癌症进展中的多维度作用
Xiaojuan Zhang,Juan Xie,Tao Fu et al.
Xiaojuan Zhang et al.
Laminin, a critical component of the basement membrane, plays an indispensable role in numerous biological processes. Among its subunits, laminin γ2 (LAMC2) emerges as a key player in the progression of cancer. This review delves into the ...
Ellagic acid inhibits EZH2: a potential epigenetic therapeutic molecule for cancer [0.03%]
ellagic酸抑制EZH2：癌症表观遗传学治疗分子的潜在候选物
Kirankumar Nalla,Biji Chatterjee,Jagadeesha Poyya et al.
Kirankumar Nalla et al.
Background: Dysregulation of epigenetic processes, characterized by aberrant DNA methylation patterns and histone modifications, is a hallmark of cancer, driving its initiation, progression, and metastasis by silencing tu...
Hi-C analysis of amplification of MYC, PVT1, and CCDC26 on marker chromosomes in the NB-4 cell line [0.03%]
NB-4 细胞系中标志染色体上MYC、PVT1和CCDC26扩增的 Hi-C 分析
Tetsuko Kobayashi,Satsuki Matsushima,Hiroaki Ohnishi
Tetsuko Kobayashi
MYC proto-oncogene may be amplified ectopically in acute myeloid leukemia (AML) as extrachromosomal DNA (ecDNA) such as double minutes (dmins). However, the mechanism and location of MYC amplification have not been fully elucidated. To char...
Development and multi-cohort validation of a prognostic risk score model for oral squamous cell carcinoma based on a three-gene signature [0.03%]
基于三基因标志物的口腔鳞癌预后风险评分模型的开发与多队列验证研究
Junxu Chen,Dongwook Kim,Jae Young Kim et al.
Junxu Chen et al.
Background: Oral squamous cell carcinoma (OSCC) carries substantial mortality despite surgery-based management. Reliable biomarkers and practical prognostic tools are needed to guide individualized care. ...