GALT protein database, a bioinformatics resource for the management and analysis of structural features of a galactosemia-related protein and its mutants [0.03%]
GALT蛋白数据库——与半乳糖血症相关的蛋白质及其突变体的结构特征管理与分析的生物信息学资源
Antonio d&#x;Acierno,Angelo Facchiano,Anna Marabotti
Antonio d&#x;Acierno
We describe the GALT-Prot database and its related web-based application that have been developed to collect information about the structural and functional effects of mutations on the human enzyme galactose-1-phosphate uridyltransferase (G...
Mingfeng Li,Yanzhao Huang,Yi Xiao
Mingfeng Li
The genetic codon UGA has a dual function: serving as a terminator and encoding selenocysteine. However, most popular gene annotation programs only take it as a stop signal, resulting in misannotation or completely missing selenoprotein gen...
Phylogenetic analysis of the neuraminidase gene reveals that the H5N1 strains prevalent in chickens during 2006 bird flu outbreaks in two regions of Maharashtra, India are genetically different [0.03%]
鸡N9基因的系统发生分析表明，在印度马哈拉施特拉邦两个地区流行的H5N1毒株在遗传上是不同的
Mohd Danishuddin,Asad U Khan
Mohd Danishuddin
In February 2006, two outbreaks of highly pathogenic avian influenza A virus subtype H5N1 occurred in chickens in two neighboring districts (first in Nandurbar and second in Jalgaon) of Maharashtra, India, in a span of 12 days. In the prese...
Role of positive selection pressure on the evolution of H5N1 hemagglutinin [0.03%]
正向选择压力在H5N1血凝素进化中的作用
Venkata R S K Duvvuri,Bhargavi Duvvuri,Wilfred R Cuff et al.
Venkata R S K Duvvuri et al.
The surface glycoprotein hemagglutinin (HA) helps the influenza A virus to evade the host immune system by antigenic variation and is a major driving force for viral evolution. In this study, the selection pressure on HA of H5N1 influenza A...
Catharine Song,Aseem Kumar,Mazen Saleh
Catharine Song
The rapid increasing number of completed bacterial genomes provides a good opportunity to compare their proteomes. This study was undertaken to specifically compare and contrast their secretomes-the fraction of the proteome with predicted N...
Comparative analysis of protein-protein interactions in cancer-associated genes [0.03%]
癌症相关基因蛋白质-蛋白质相互作用的比较分析
Purnima Guda,Sridar V Chittur,Chittibabu Guda
Purnima Guda
Protein-protein interactions (PPIs) have been widely studied to understand the biological processes or molecular functions associated with different disease systems like cancer. While focused studies on individual cancers have generated val...
DNA copy number aberrations in breast cancer by array comparative genomic hybridization [0.03%]
乳腺癌的DNA倍体变化异常的数组比较基因组杂交分析
Jian Li,Kai Wang,Shengting Li et al.
Jian Li et al.
Array comparative genomic hybridization (CGH) has been popularly used for analyzing DNA copy number variations in diseases like cancer. In this study, we investigated 82 sporadic samples from 49 breast cancer patients using 1-Mb resolution ...
In-depth cDNA library sequencing provides quantitative gene expression profiling in cancer biomarker discovery [0.03%]
深入的cDNA文库测序可提供癌症生物标志物发现中的定量基因表达谱分析
Wanling Yang,Dingge Ying,Yu-Lung Lau
Wanling Yang
Quantitative gene expression analysis plays an important role in identifying differentially expressed genes in various pathological states, gene expression regulation and co-regulation, shedding light on gene functions. Although microarray ...
GDBIG: A Pioneering Birth Cohort Genomic Platform Facilitating Intergenerational Genetic Research [0.03%]
GDBIG：一个促进代际遗传研究的开创性出生队列基因组平台
High-quality genome databases derived from large-scale, family-based birth cohorts are vital resources for investigating the genetic determinants of early-life traits and the impact of early-life environments on the health of both parents a...