Deciphering Haploid Chromosome Conformation Alternation in Down Syndrome by Multiple Haploid Omics Analysis [0.03%]
利用单倍体组学分析解码唐氏综合症中的单倍体染色体构象变化
Chengchao Wu,Tianshu Zhou,Wenfu Ke et al.
Chengchao Wu et al.
For chromosome abnormalities (CA), such as Down syndrome (DS), the influence of genomic variations to chromosome conformation and gene transcription remains elusive. Based on the complete genomic sequence from the parents of the DS trisomy ...
Spatial Transcriptomics Unveils the Blueprint of Mammalian Lung Development [0.03%]
空间转录组学揭示哺乳动物肺发育蓝图
Mingyue Chen 陈明月,Junjie Lv 吕俊杰,Qiao Zhang 张乔 et al.
Mingyue Chen 陈明月 et al.
Mammalian lung development is a complex, highly orchestrated process involving the precise coordination of diverse cell types. Despite significant advances, the spatial gene expression patterns and regulatory mechanisms within the developme...
SRPS: Survival Reinforced Transfer Learning for Multicentric Proteomic Subtyping and Biomarker Discovery [0.03%]
基于生存强化迁移学习的多中心蛋白质组分型及标志物发现方法
Linhai Xie,Pei Jiang,Cheng Chang
Linhai Xie
Omics-based molecular subtyping in large-scale and multicentric cohort studies is a prerequisite for proteomics-driven precision medicine (PDPM). However, keeping the subtypes with robust molecular features and significant associations with...
Proteome and Phosphoproteome of Tomato Fruit Identify REDUCED CHLOROPLAST COVERAGE 1a as A Ripening Regulator [0.03%]
番茄果实蛋白组和磷酸化蛋白质组鉴定出一个调控果实 ripening 的新因子 REDUCED CHLOROPLAST COVERAGE 1a
Jinjuan Tan,Zhongjing Zhou,Hanqian Feng et al.
Jinjuan Tan et al.
Fruit ripening in tomato (Solanum lycopersicum) has been extensively studied at the transcriptomics level. However, comprehensive profiling of the tomato fruit proteome and phosphoproteome remains limited. In this study, we performed large-...
YanHuang Paternal Genomic Resource Suggested A Weakly-Differentiated Multi-Source Admixture Model for the Formation of Han's Founding Ancestral Lineages [0.03%]
黄帝牌男性基因组资源揭示了汉人始祖人群的弱分化多来源谱系 admix 模型
Zhiyong Wang,Kaijun Liu,Haibing Yuan et al.
Zhiyong Wang et al.
The revolution in large-scale human genomics and advancements in statistical methods have profoundly refined our understanding of genetic diversity and structure within human populations. Y-chromosome variations, with their distinct evoluti...
Unveiling Neonatal Pneumonia Microbiome by High-Throughput Sequencing and Droplet Culturomics [0.03%]
通过高通量测序和微滴培养组学技术解构新生儿肺炎微生物组
Zerui Wang,Xin Cheng,Yibin Xu et al.
Zerui Wang et al.
Neonatal pneumonia is a leading cause of infant mortality worldwide; however, a lack of microbial profiling, especially of low-abundance species, makes accurate diagnosis challenging. Traditional methods can fail to capture the complexity o...
Chen Wang,Hong Zhao,Hongkui Zhang et al.
Chen Wang et al.
Self-incompatibility (SI) is an important genetic mechanism in angiosperms that prevents inbreeding and promotes outcrossing, with significant implications for crop breeding, including genetic diversity, hybrid seed production, and yield op...
CircAge: A Comprehensive Resource for Aging-associated Circular RNAs Across Species and Tissues [0.03%]
CircAge：一个跨物种和组织的与衰老相关的环状RNA综合资源
Xin Dong,Zhen Zhou,Yanan Wang et al.
Xin Dong et al.
Circular RNAs (circRNAs) represent a novel class of RNA molecules characterized by a circular structure and enhanced stability. Emerging evidence indicates that circRNAs play pivotal regulatory roles in the aging process. Despite this, ther...
Jenea I Adams,Eric Kutschera,Qiang Hu et al.
Jenea I Adams et al.
Although gene expression analysis pipelines are often a standard part of bioinformatics analysis, with many publicly available cloud workflows, cloud-based alternative splicing analysis tools remain limited. Our lab released rMATS in 2014 a...
The Implication of The Vaginal Microbiome in Female Infertility and Assisted Conception Outcomes [0.03%]
女性生育力和辅助生殖结局的阴道微生态影响分析
Xiuju Chen,Yanyu Sui,Jiayi Gu et al.
Xiuju Chen et al.
The rise in infertility rates has prompted research into the impact of vaginal microbiota on female fertility and assisted reproduction technology (ART) success. Our study compares the vaginal microbiome of fertile and infertile women and e...