Single-cell RNA Sequencing Discovered Subtypes Associated with Angiogenesis and Propranolol Treatment in Infantile Hemangioma [0.03%]
单细胞RNA测序发现与血管形成和普萘洛尔治疗相关的婴幼儿血管瘤亚型
Qiang Chen,Liuqing Yang,Sili Ni et al.
Qiang Chen et al.
Infantile hemangioma (IH), a benign vascular tumor of infancy, is characterized by rapid postnatal growth and subsequent spontaneous resolution. Although propranolol, initially developed for cardiovascular disorders, is the primary treatmen...
The 2025 Westlake Autumn Symposium for Al Proteomics and Virtual Cell [0.03%]
2025西湖秋季单原子蛋白组学和虚拟细胞研讨会
Rui Sun,Ruedi Aebersold,Qi Xiao et al.
Rui Sun et al.
Comprehensive Epitranscriptome Analysis from MeRIP-seq Data with exomePeak2 [0.03%]
利用exomePeak2从MeRIP-seq数据进行全面的表转录组分析
Jingxian Zhou,Zhen Wei,Di Zhen et al.
Jingxian Zhou et al.
As the most abundant internal RNA modification, N 6-methyladenosine (m6A) affects the fate of RNA through various mechanisms and regulates essential biological processes. In this study, we developed exomePeak2, a novel computational tool fo...
Toward A Pre-disease State-centered New Paradigm in Multi-omics Research [0.03%]
迈向多组学研究的以疾病前期状态为中心的新范式
Cheng Lu,Yan Li,Quansheng Du
Cheng Lu
Integrated multi-omics approaches have fundamentally redefined investigative framework in systems biology and precision medicine. Despite substantial technological progress, precise molecular characterization of pre-disease states remains a...
Spatial Single-cell Transcriptome Atlas of Mouse Thymus Reveals the T Lymphocyte Dynamics During Development [0.03%]
小鼠胸腺空间单细胞转录组图谱揭示T淋巴细胞发育动力学
Jiahao Zhang,Huaiyuan Cai,Chuanyuan Lu et al.
Jiahao Zhang et al.
The thymus provides a crucial microenvironment for lymphocyte development, undergoes rapid growth by progressive atrophy, yet the underlying molecular dynamics remain largely unclear. Here, we present a comprehensive single-cell transcripto...
Unraveling the Phylogenetic Signal of Gene Expression from Single-cell RNA-seq Data [0.03%]
从单细胞RNA测序数据中解析基因表达的系统发育信号
Joao M Alves,Laura Tomás,David Posada
Joao M Alves
Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of phenotypic heterogeneity. Although the predominant focus of scRNA-seq analyses has been assessing gene expression changes, several approaches have been proposed in ...
Benchmarking Generative AI Protein Models Reveals Differences Between Structural and Sequence-based Approaches [0.03%]
基准测试生成式AI蛋白质模型揭示结构与序列基础方法之间的差异
Alexander J Barnett,Rajendra Kc,Pratikshya Pandey et al.
Alexander J Barnett et al.
Recent advances in artificial intelligence have led to the development of generative models for de novo protein design. We compared 13 state-of-the-art generative protein models, assessing their ability to produce feasible, diverse, and nov...
ProtRAP-LM: Efficient Protein Relative Accessibility Prediction and Proteome-wide Membrane Protein Screening [0.03%]
高效蛋白质相对可及性预测和全基因组膜蛋白筛选的ProtRAP-LM模型
Lei Wang,Kai Kang,Chen Song
Lei Wang
Membrane proteins play pivotal roles in cellular signaling and transport, making them prime targets for therapeutic intervention. Therefore, rapid screening and accurate property prediction of these proteins are essential. Recently, we prop...
Genome-wide Analysis Reveals the Genetic Basis of Key Agronomic Traits and Modern Wheat Breeding in Henan Province [0.03%]
全基因组分析揭示河南小麦主要农艺性状的遗传基础及现代育种动向
Chaojun Peng,Ying Chen,Xuelian Han et al.
Chaojun Peng et al.
Although wheat cultivars and yields in Henan Province have improved continuously, there have been no systematic reports on breeding improvement in recent decades. This study aims to elucidate the genetic basis of these wheat cultivars and s...