Shared Genetic Factors Between Stress-related Disorders and Cardiovascular Disease [0.03%]
应激相关障碍和心血管疾病共有的遗传因素
Can Hou,Yu Zeng,Huazhen Yang et al.
Can Hou et al.
Understanding whether and how shared genetic factors contribute to the comorbidity between stress-related disorders (SRDs) and cardiovascular disease (CVD) is important for integrated prevention and treatment, but current evidence remains l...
Bispecific Antibodies in Cancer Immunotherapy: Mechanisms, Challenges, and Emerging Therapeutic Strategies [0.03%]
癌症免疫治疗中的双特异性抗体：机制、挑战及新兴的治疗策略
Yao Wu,Mingjie Liao,Han Chen et al.
Yao Wu et al.
Bispecific antibodies (BsAbs) have emerged as a promising therapeutic strategy in cancer immunotherapy, enabling simultaneous targeting of two distinct antigens to redirect immune effector cells, block compensatory pathways, and modulate th...
COACH-D 2.0: A Server for Template-based Modeling of Protein-ligand Interactions [0.03%]
COACH-D 2.0：基于模板的蛋白质-配体相互作用模型服务器
Xiaoyu An,Hong Wei,Wenkai Wang et al.
Xiaoyu An et al.
Protein structure prediction has been transformed by AlphaFold2 and related systems; however, accurately modeling protein-ligand interactions remains a major challenge. Template-based prediction using homologous structures remains a powerfu...
SPAE: Deciphering Cell Cycle Dynamics and Cell States in Single-cell RNA-seq Data [0.03%]
SPAE：解析单细胞RNA测序数据中的细胞周期动态和细胞状态
Jiahao Yi,Jiajia Liu,Peng Guo et al.
Jiahao Yi et al.
Rapid advances in single-cell RNA sequencing (scRNA-seq) technology have enabled the investigation of gene expression changes at the single-cell level, particularly for elucidating the heterogeneity among cells and complex biological proces...
Jian-Rong He,Dongmei Wei,Mingxi Huang et al.
Jian-Rong He et al.
Adverse exposures during early life, including environmental and genetic factors, can have profound and long-lasting effects on health in later life. Birth cohorts provide invaluable platforms for studying these effects, as they enable the ...
DNA Methylation in Sex Chromosomes and Genes under Selection Underpins Sexual Size Dimorphism [0.03%]
性染色体和受自然选择作用的基因的DNA甲基化决定了两性的体型差异大小
Qian Wang,Xiancai Hao,Dafni Anastasiadi et al.
Qian Wang et al.
Sexual size dimorphism (SSD) refers to the differences in body size between males and females. Epigenetic mechanisms, such as DNA methylation, can shape phenotypes; however, their role in SSD remains unclear. Here, we used Cynoglossus semil...
scReGAT: Leveraging Knowledge of Regulatory Interactions to Predict Long-range Gene Regulation at Single-cell Resolution [0.03%]
利用调控相互作用的知识在单细胞分辨率下预测长程基因调控 scReGAT
Baole Wen,Yanan Dang,Yu Zhang et al.
Baole Wen et al.
Understanding gene regulation at single-cell resolution is crucial for unraveling development, disease, and cellular identity. We introduce single-cell regulatory graph attention network (scReGAT), a deep learning framework that integrates ...
WebCVTree4: Phylogenetic and Taxonomic Study Platform for Prokaryotes base on Whole Genomes [0.03%]
WebCVTree4：基于全基因组的原核生物系统发育和分类学研究平台
Guanghong Zuo
Guanghong Zuo
CVTree is an alignment-free methodology for inferring species phylogeny and taxonomy. This method allows for the efficient and accurate resolution of evolutionary relationships among large numbers of species based on whole-genome sequencing...
A Global Structural Variation Map Reveals Novel Variants for Body Conformation and Racing Ability in Horses [0.03%]
绘制全球结构变异图揭示了影响马身体形态和赛跑能力的新突变
Ying Gong,Xuexue Liu,Zhuqing Zheng et al.
Ying Gong et al.
The selection of horses has been instrumental in shaping long-range mobility, advancing warfare strategies, and diversifying equine phenotypes. However, the structural variants (SVs) favored by this process remain largely unexplored. Utiliz...
Yulun Wu,Tao Jiang,Bo Zhu et al.
Yulun Wu et al.
Antitumor immunity depends on a self-reinforcing cancer-immunity cycle, yet many tumors evade critical steps and respond poorly to checkpoint blockade. Emerging evidence indicates that gut microbiota-derived systemic cues could influence th...