Meta-QC-Chain: comprehensive and fast quality control method for metagenomic data [0.03%]
元基因组数据的全面快速质量控制方法(meta-QC-Chain)
Qian Zhou,Xiaoquan Su,Gongchao Jing et al.
Qian Zhou et al.
Next-generation sequencing (NGS) technology has revolutionized and significantly impacted metagenomic research. However, the NGS data usually contains sequencing artifacts such as low-quality reads and contaminating reads, which will signif...
Yan Zeng
Yan Zeng
A biological molecule, e.g., an enzyme, tends to interact with its many cognate substrates, targets, or partners differentially. Such a property is termed relative specificity and has been proposed to regulate important physiological functi...
Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells [0.03%]
人组织和培养的大鼠脑细胞中miR-15/107家族微小RNA的表达
Wang-Xia Wang,Robert J Danaher,Craig S Miller et al.
Wang-Xia Wang et al.
The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs), sharing a 5' AGCAGC sequence. These miRNAs have overlapping targets. In order to characterize the expression of miR-15/107 family miRNAs, we employed customized Ta...
Xiaolei Zhao,Shouqiang Zhong,Xiaoyu Zuo et al.
Xiaolei Zhao et al.
Many cancers apparently showing similar phenotypes are actually distinct at the molecular level, leading to very different responses to the same treatment. It has been recently demonstrated that pathway-based approaches are robust and relia...
A TDG/CBP/RARα ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes [0.03%]
视黄酸依赖的DNA甲基化敏感基因表达受TDG/CBP/RARα三元复合体调控
Hélène Léger,Caroline Smet-Nocca,Amel Attmane-Elakeb et al.
Hélène Léger et al.
The thymine DNA glycosylase (TDG) is a multifunctional enzyme, which is essential for embryonic development. It mediates the base excision repair (BER) of G:T and G:U DNA mismatches arising from the deamination of 5-methyl cytosine (5-MeC) ...
Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics [0.03%]
动手实践研讨会是学习基因组学、蛋白质组学和生物信息学等先进技术的有效途径
Nichole Reisdorph,Robert Stearman,Katerina Kechris et al.
Nichole Reisdorph et al.
Genomics and proteomics have emerged as key technologies in biomedical research, resulting in a surge of interest in training by investigators keen to incorporate these technologies into their research. At least two types of training can be...
Identification of immunity-related genes in Arabidopsis and cassava using genomic data [0.03%]
基于基因组数据鉴定拟南芥和木薯的免疫相关基因
Luis Guillermo Leal,Álvaro Perez,Andrés Quintero et al.
Luis Guillermo Leal et al.
Recent advances in genomic and post-genomic technologies have provided the opportunity to generate a previously unimaginable amount of information. However, biological knowledge is still needed to improve the understanding of complex mechan...
Bagging with CTD--a novel signature for the hierarchical prediction of secreted protein trafficking in eukaryotes [0.03%]
基于CTD的装袋法在真核生物分泌蛋白分选通路中的层级预测中研究
Geetha Govindan,Achuthsankar S Nair
Geetha Govindan
Protein trafficking or protein sorting in eukaryotes is a complicated process and is carried out based on the information contained in the protein. Many methods reported prediction of the subcellular location of proteins from sequence infor...
Identification of the phosphorylated residues in TveIF5A by mass spectrometry [0.03%]
质谱鉴定TveIF5A的磷酸化位点
Laura Itzel Quintas-Granados,César López-Camarillo,Jesús Fandiño Armas et al.
Laura Itzel Quintas-Granados et al.
The initiation factor eIF5A in Trichomonas vaginalis (TveIF5A) is previously shown to undergo hypusination, phosphorylation and glycosylation. Three different pI isoforms of TveIF5A have been reported. The most acidic isoform (pI 5.2) corre...
Screening preeclamptic cord plasma for proteins associated with decreased breast cancer susceptibility [0.03%]
筛选用于降低乳腺癌易感性的子痫前期脐带血浆蛋白
Hoi Pang Low,Ashutosh Tiwari,Jagadeesh Janjanam et al.
Hoi Pang Low et al.
Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this protective effect could be due to exposure to preeclampsia-...