A Single-cell Transcriptome-wide Association Study Reveals Susceptibility Genes for Age-related Hearing Loss [0.03%]
单细胞转录组关联研究揭示与年龄相关听力损失的易感基因
Yuanfeng Li,Tao Zeng,Wenyu Song et al.
Yuanfeng Li et al.
Age-related hearing loss (ARHL) is the most common type of hearing loss. Genetic factors are considered to play important roles in the development of ARHL. To identify novel susceptibility genes and cell types relevant to ARHL, we performed...
MaizeGEP: A Maize Hybrids Dataset with Genotype, Phenotype, and Envirotype to Develop Genomic Selection Models [0.03%]
MaizeGEP：一个包含基因型、表型和环境类型的玉米杂交品种数据集，用于开发基因组选择模型
Dongfeng Zhang,Yanyun Han,Shouhui Pan et al.
Dongfeng Zhang et al.
The integration of genotype with envirotype is essential for achieving precise phenotypic prediction. However, there is currently a scarcity of datasets derived from variety approval testing trials that encompass a broad spectrum of trial l...
REC8-Cohesin Preferentially Localizes to Promoters of Genes that are Regulated by Transcription Suppressor BEND2 During Early Meiosis [0.03%]
载荷蛋白REC8在早期减数分裂时优先定位到转录阻遏蛋白BEND2调控的基因启动子上
Dan Xie,Longfei Ma,Jing Sun et al.
Dan Xie et al.
Cohesin plays critical roles in chromatin organization and transcription regulation. REC8 is a meiosis-specific cohesin subunit and is essential for homologous chromosome synapsis, recombination, and segregation. However, little is known ab...
Benchmark and Evaluation for Somatic Structural Variants Detection with Long-read Sequencing Data [0.03%]
基于长读段测序数据的体细胞结构变异检测基准和评估
Ziting Feng,Xuyan Liu,Yahui Liu et al.
Ziting Feng et al.
Somatic structural variations (somatic SVs) are hallmarks of tumors, but their comprehensive detection remains technically challenging. Long-read sequencing (LRS) technology, which generates reads spanning large-scale SVs and their flanking...
iRUNNER: A Baseline Mutation Burden Regression for Identifying Gene Interaction Between Rare Variants for Diseases [0.03%]
基于罕见变异基因交互作用的疾病基线突变负荷回归:iRunner系统
Hui Jiang,Bin Tang,Kun Li et al.
Hui Jiang et al.
Genetic interactions play a crucial role in elucidating the susceptibility and etiology of complex multifactorial diseases. Despite significant efforts to identify disease-associated nonlinear effects in genome-wide association studies, eff...
Multiomics Analysis Reveals How Intratumoral Bacteria Shape the Immune Microenvironment in Gastric Cancer [0.03%]
多组学分析揭示了肿瘤内细菌如何塑造胃癌免疫微环境
Yang Mi,Die Dai,Xia Xue et al.
Yang Mi et al.
The occurrence and progression of gastric cancer (GC) are closely associated with dysbiosis of the gastric microbiota and alteration in host microenvironments. However, the interaction between intratumoral bacteria and gastric microenvironm...
Long-read Sequencing Reveals Repeat Expansions and Large Structural Variants in Oral Squamous Cell Carcinoma [0.03%]
长读取测序揭示口腔鳞状细胞癌中的重复扩增和大型结构变异
Li Hu,Jiaxun Zhang,Zhuoyuan Zhang et al.
Li Hu et al.
Previous genomic studies have predominantly analyzed oral squamous cell carcinoma (OSCC) in conjunction with other head and neck squamous cell carcinomas (HNSCC), constraining our comprehension of OSCC-specific structural variants (SVs). He...
Unveiling Tissue Structure and Tumor Microenvironment from Spatial Omics by Hypergraph Learning [0.03%]
基于超图学习的空间组学技术在揭示组织结构和肿瘤微环境中的应用
Yi Liao,Chong Zhang,Zhikang Wang et al.
Yi Liao et al.
Spatial omics technologies have revolutionized life sciences by enabling the simultaneous acquisition of biomolecular and spatial information. Identifying spatial patterns is crucial for understanding organ development and tumor microenviro...
MPCutter: Predicting Protease-specific Substrate Cleavage Sites Using a Protein Language Model [0.03%]
MPCutter：使用蛋白质语言模型预测蛋白酶特异性底物切割位点
Zhe Wang,Tuoyu Liu,Guoshun Xu et al.
Zhe Wang et al.
Proteases can cleave peptide bonds of target substrate proteins. Their controlled proteolysis is vital for protein degradation, recycling, and physiological processes. Understanding the hydrolytic mechanisms of proteases is crucial, particu...
The Indicine X-linked CYBBL237M Mutation Can Suppress Intracellular Infection with Tubercle Bacilli [0.03%]
印度枣X染色体连锁的CYBBL237M突变可抑制结核分枝杆菌胞内感染
Haoxin Wang,Xiaoting Xia,Lulan Zeng et al.
Haoxin Wang et al.
Indicine cattle exhibit superior resistance to Mycobacterium bovis infection compared to taurine breeds, revealing divergent genetic mechanisms underlying bovine tuberculosis (bTB) resilience. Previous research has demonstrated that Cytochr...