Bioinformatic Resources for Exploring Human-virus Protein-protein Interactions Based on Binding Modes [0.03%]
基于结合模式的人类病毒蛋白质相互作用的生物信息资源探究
Huimin Chen,Jiaxin Liu,Gege Tang et al.
Huimin Chen et al.
Historically, there have been many outbreaks of viral diseases that have continued to claim millions of lives. Research on human-virus protein-protein interactions (PPIs) is vital to understanding the principles of human-virus relationships...
SuperFeat: Quantitative Feature Learning from Single-cell RNA-seq Data Facilitates Drug Repurposing [0.03%]
基于单细胞RNA测序数据的定量特征学习促进药物重定位
Jianmei Zhong,Junyao Yang,Yinghui Song et al.
Jianmei Zhong et al.
In this study, we devised a computational framework called Supervised Feature Learning and Scoring (SuperFeat) which enables the training of a machine learning model and evaluates the canonical cellular statuses/features in pathological tis...
Global Invasion History and Genomic Signatures of Adaptation of the Highly Invasive Sycamore Lace Bug [0.03%]
榆枫绵蚜的全球入侵历史及适应性进化基因组信号研究
Zhenyong Du,Xuan Wang,Yuange Duan et al.
Zhenyong Du et al.
Invasive species cause massive economic and ecological damage. Climate change has resulted in an unprecedented increase in the number and impact of invasive species; however, the mechanisms underlying these invasions are unclear. The sycamo...
Inter3D: Capture of TAD Reorganization Endows Variant Patterns of Gene Transcription [0.03%]
Inter3D：拓扑结构域重组导致基因转录的变异模式
Tianyi Ding,Shaliu Fu,Xiaoyu Zhang et al.
Tianyi Ding et al.
Topologically associating domain (TAD) reorganization commonly occurs in the cell nucleus and contributes to gene activation and inhibition through the separation or fusion of adjacent TADs. However, functional genes impacted by TAD alterat...
RAG-seq: NSR-primed and Transposase Tagmentation-mediated Strand-specific Total RNA Sequencing in Single Cells [0.03%]
基于NSR和转座酶片段化的单细胞全长RNA单分子测序技术(RAG-seq)
Ping Xu,Zhiheng Yuan,Xiaohua Lu et al.
Ping Xu et al.
Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of cellular diversity with unprecedented resolution. However, many current methods are limited in capturing full-length transcripts and discerning strand orientation. ...
Ming-Xiao Zhao,Ruo-Fan Ding,Qiang Chen et al.
Ming-Xiao Zhao et al.
Protein N-phosphorylation is widely present in nature and participates in various biological processes. However, current knowledge on N-phosphorylation is extremely limited compared to that on O-phosphorylation. In this study, we collected ...
SMARTdb: An Integrated Database for Exploring Single-cell Multi-omics Data of Reproductive Medicine [0.03%]
SMARTdb：一个用于探索生殖医学单细胞多组学数据的集成数据库
Zekai Liu,Zhen Yuan,Yunlei Guo et al.
Zekai Liu et al.
Single-cell multi-omics sequencing has greatly accelerated reproductive research in recent years, and the data are continually growing. However, utilizing these data resources is challenging for wet-lab researchers. A comprehensive platform...
GP-Plotter: Flexible Spectral Visualization for Proteomics Data with Emphasis on Glycoproteomics Analysis [0.03%]
GP-Plotter：用于组学数据的灵活光谱可视化，着重于糖蛋白质组学分析
Zheng Fang,Mingming Dong,Hongqiang Qin et al.
Zheng Fang et al.
Identification evaluation and result dissemination are essential components in mass spectrometry-based proteomics analysis. The visualization of fragment ions in mass spectrum provides strong evidence for peptide identification and modifica...
Enhancing Variant Calling in Whole-exome Sequencing Data Using Population-matched Reference Genomes [0.03%]
利用匹配的参考基因组增强外显子组测序数据中的变异检测能力
Shuming Guo,Zhuo Huang,Yanming Zhang et al.
Shuming Guo et al.
Whole-exome sequencing (WES) data are frequently used for cancer diagnosis and genome-wide association studies (GWAS), based on high-coverage read mapping, informative variant calling, and high-quality reference genomes. The center position...
CIEC: Cross-tissue Immune Cell Type Enrichment and Expression Map Visualization for Cancer [0.03%]
肿瘤的跨组织免疫细胞类型富集和表达图谱可视化方法(CIEC)
Jinhua He,Haitao Luo,Wei Wang et al.
Jinhua He et al.
Single-cell transcriptome sequencing technology has been applied to decode the cell types and functional states of immune cells, revealing their tissue-specific gene expression patterns and functions in cancer immunity. Comprehensive assess...