NeoTCR: an immunoinformatic database of experimentally-supported functional neoantigen-specific TCR sequences [0.03%]
NeoTCR：一个实验支持的特异性识别新抗原T细胞受体序列免疫信息数据库
Weijun Zhou,Wenting Xiang,Jinyi Yu et al.
Weijun Zhou et al.
Neoantigen-based immunotherapy has demonstrated long-lasting antitumor activity. The recognition of neoantigens by T cell receptors (TCRs) is considered a trigger for antitumor responses. Due to the overwhelming number of TCR repertoires in...
TCRosetta: An Integrated Analysis and Annotation Platform for T-cell Receptor Sequences [0.03%]
TCRosetta：T细胞受体序列的综合分析和注释平台
Tao Yue,Si-Yi Chen,Wen-Kang Shen et al.
Tao Yue et al.
T cells and T-cell receptors (TCRs) are essential components of the adaptive immune system. Characterization of the TCR repertoire offers a promising and highly informative source for understanding the functions of T cells in the immune res...
EryDB: A Transcriptomic Profile Database for Erythropoiesis and Erythroid-related Diseases [0.03%]
EryDB：一个促进红细胞生成及红细胞性疾病的转录谱资料库
Guangmin Zheng,Song Wu,Zhaojun Zhang et al.
Guangmin Zheng et al.
Erythropoiesis is a finely regulated and complex process that involves multiple transformations from hematopoietic stem cells to mature red blood cells at hematopoietic sites from the embryonic to the adult stages. Investigations into its m...
Mingyue Cheng,Hong Zhou,Haobo Zhang et al.
Mingyue Cheng et al.
Despite the skin microbiome has been linked to skin health and diseases, its role in modulating human skin appearance remains understudied. Using a total of 1244 face imaging phenomes and 246 cheek metagenomes, we first established three sk...
Scm6A: A Fast and Low-cost Method for Quantifying m6A Modifications at the Single-cell Level [0.03%]
scM6A：一种快速且低成本的单细胞水平m6A定量方法
Yueqi Li,Jingyi Li,Wenxing Li et al.
Yueqi Li et al.
It is widely accepted that N6-methyladenosine (m6A) exhibits significant intercellular specificity, which poses challenges for its detection using existing m6A quantitative methods. In this study, we introduced Single-cell m6A Analysis (Scm...
Aberrant Somatic Hypermutation at Super-enhancer Drives B Cell Lymphoma Transformation [0.03%]
超增强子异常体细胞高频突变驱动B淋巴细胞瘤转化
Xueshuai Han,Zhaoqi Liu
Xueshuai Han
Shenghan Gao,Yimeng Zhang,Stephen J Bush et al.
Shenghan Gao et al.
High-fidelity (HiFi) sequencing has facilitated the assembly and analysis of the most repetitive region of the genome, the centromere. Nevertheless, our current understanding of human centromeres is based on a relatively small number of tel...
DeOri 10.0: An Updated Database of Experimentally Identified Eukaryotic Replication Origins [0.03%]
DeOri 10.0：一个更新的真核生物复制起点实验鉴定数据库
Yu-Hao Zeng,Zhen-Ning Yin,Hao Luo et al.
Yu-Hao Zeng et al.
DNA replication is a complex and crucial biological process in eukaryotes. To facilitate the study of eukaryotic replication events, we present a database of eukaryotic DNA replication origins (DeOri), which collects genome-wide data on euk...
MitoSort: Robust Demultiplexing of Pooled Single-cell Genomic Data Using Endogenous Mitochondrial Variants [0.03%]
基于内源性线粒体变异的 pooled 单细胞基因组数据稳健拆分工具 MitoSort
Zhongjie Tang,Weixing Zhang,Peiyu Shi et al.
Zhongjie Tang et al.
Multiplexing across donors has emerged as a popular strategy to increase throughput, reduce costs, overcome technical batch effects, and improve doublet detection in single-cell genomic studies. To eliminate additional experimental steps, e...