Comparative Analysis of CRISPR/Cas9-targeted Nanopore Sequencing Approaches in Repeat Expansion Disorders [0.03%]
CRISPR/Cas9靶向纳米孔测序在重复序列扩张障碍中的比较分析研究
Louise Benarroch,Pierre-Yves Boëlle,Hélène Madry et al.
Louise Benarroch et al.
More than 50 repeat expansion disorders have been identified, with long-read sequencing marking a new milestone in the diagnosis of these disorders. Despite these major achievements, the comprehensive characterization of short tandem repeat...
cfMethDB: A Comprehensive cfDNA Methylation Data Resource for Cancer Biomarkers [0.03%]
cfMethDB：癌症生物标志物的全面循环DNA甲基化数据资源
Yuanhui Sun,Zhixian Zhu,Qiangwei Zhou et al.
Yuanhui Sun et al.
Cancer is a major global health threat, and early detection is crucial for improving patient outcomes. DNA methylation in circulating cell-free DNA (cfDNA) has emerged as a promising biomarker for non-invasive cancer diagnosis. However, the...
DeRR: A Unique Detecting Method and the First Landscape for T Cells with Dual T Cell Receptors from Large-scale Single Cell Data [0.03%]
基于大规模单细胞数据检测并绘制双重T细胞受体T细胞的新方法及成果景观
Si-Yi Chen,Lingzi Mao,Xin Fu et al.
Si-Yi Chen et al.
While most T cells exclusively express a single T cell receptor (TCR), a distinct subpopulation exhibits dual types of TCR expression (dual-TCR). Although the functional implications of dual-TCR T cells in autoimmunity and immune protection...
Spatial Transcriptomics of Human Decidua Identifies Molecular Signatures in Recurrent Pregnancy Loss [0.03%]
人蜕膜的空間轉錄組學識別反復流產的分子標簽
Qing Sha,Qiaoni Yu,Kaixing Chen et al.
Qing Sha et al.
The human decidua establishes immune tolerance at the maternal-fetal interface and is essential for successful embryo implantation and development. Here, we conducted a spatial transcriptomic analysis of human decidua from early pregnancies...
Histo-LCM-Hi-C Reveals 3D Chromatin Conformations of Spatially Localized Rare Cells in Tissues at High Resolution [0.03%]
高分辨率下Histo-LCM-Hi-C揭示组织中空间定位的稀有细胞的三维染色质构象
Yixin Liu,Min Chen,Xin Liu et al.
Yixin Liu et al.
It is now well established that an understanding of the chromatin structure is essential to delineate the mechanisms underlying genomic processes. However, while methods to obtain this information from cells in vitro are widely available, t...
Two Isatis Genomes Reveal the Biosynthesis and Evolutionary Origin of Indigo in Plants [0.03%]
两个板蓝根基因组揭示植物中靛青的生物合成及起源演化
Junfeng Chen,Hexin Tan,Jun Yang et al.
Junfeng Chen et al.
Indigo, a plant-originated blue dye, has a long and well-documented history of extensive human use. The Isatis genus has long been a key source for indigo production, however, the biosynthetic pathway responsible for indigo within Isatis ha...
A Co-essentiality Network of Cancer Driver Genes Better Prioritizes Anticancer Drugs [0.03%]
一个癌症驱动基因共必需网络能更好地优先确定抗癌药物
Kwanghwan Lee,Donghyo Kim,Inhae Kim et al.
Kwanghwan Lee et al.
Diverse molecular networks have been extensively studied to discover therapeutic targets and repurpose approved drugs. However, it is necessary to select a suitable network since the performance of network medicine relies heavily on the com...
DisConST: Distribution-aware Contrastive Learning for Spatial Domain Identification [0.03%]
基于分布感知的对比学习的空间域识别方法
Peimeng Zhen,Xiaofeng Wang,Han Shu et al.
Peimeng Zhen et al.
Spatial transcriptomics (ST) is a cutting-edge technology that provides comprehensive insights into gene expression patterns from a spatial perspective. A key research focus within this field is spatial domain identification, which is essen...
PASSpedia: A Polyadenylation Site Database Across Different Species at Single Cell Resolution [0.03%]
PASSpedia：单细胞分辨率下多腺苷酸化位点数据库跨物种汇总
Pei-Hong Zhang,Hua Feng,Xu-Kai Ma et al.
Pei-Hong Zhang et al.
Polyadenylation site (PAS) selection plays important roles in gene expression regulation and function. RNA-seq data derived from 3' tag sequencing contain intrinsic information about PAS usage and have been analyzed for alternative polyaden...
Zhenyu Huang,Xuechen Mu,Qiufen Chen et al.
Zhenyu Huang et al.
Intracellular alkalosis and extracellular acidosis are well-established characteristics of Alzheimer's disease (AD). We present a computational analysis and modeling of transcriptomic data of AD tissues, aiming to understand their causes an...