Spatial Single-cell Transcriptome Atlas of Mouse Thymus Reveals the T Lymphocyte Dynamics During Development [0.03%]
小鼠胸腺空间单细胞转录组图谱揭示T淋巴细胞发育动力学
Jiahao Zhang,Huaiyuan Cai,Chuanyuan Lu et al.
Jiahao Zhang et al.
The thymus provides a crucial microenvironment for lymphocyte development, undergoes rapid growth by progressive atrophy, yet the underlying molecular dynamics remain largely unclear. Here, we present a comprehensive single-cell transcripto...
Unraveling the Phylogenetic Signal of Gene Expression from Single-cell RNA-seq Data [0.03%]
从单细胞RNA测序数据中解析基因表达的系统发育信号
Joao M Alves,Laura Tomás,David Posada
Joao M Alves
Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of phenotypic heterogeneity. Although the predominant focus of scRNA-seq analyses has been assessing gene expression changes, several approaches have been proposed in ...
Benchmarking Generative AI Protein Models Reveals Differences Between Structural and Sequence-based Approaches [0.03%]
基准测试生成式AI蛋白质模型揭示结构与序列基础方法之间的差异
Alexander J Barnett,Rajendra Kc,Pratikshya Pandey et al.
Alexander J Barnett et al.
Recent advances in artificial intelligence have led to the development of generative models for de novo protein design. We compared 13 state-of-the-art generative protein models, assessing their ability to produce feasible, diverse, and nov...
ProtRAP-LM: Efficient Protein Relative Accessibility Prediction and Proteome-wide Membrane Protein Screening [0.03%]
高效蛋白质相对可及性预测和全基因组膜蛋白筛选的ProtRAP-LM模型
Lei Wang,Kai Kang,Chen Song
Lei Wang
Membrane proteins play pivotal roles in cellular signaling and transport, making them prime targets for therapeutic intervention. Therefore, rapid screening and accurate property prediction of these proteins are essential. Recently, we prop...
Genome-wide Analysis Reveals the Genetic Basis of Key Agronomic Traits and Modern Wheat Breeding in Henan Province [0.03%]
全基因组分析揭示河南小麦主要农艺性状的遗传基础及现代育种动向
Chaojun Peng,Ying Chen,Xuelian Han et al.
Chaojun Peng et al.
Although wheat cultivars and yields in Henan Province have improved continuously, there have been no systematic reports on breeding improvement in recent decades. This study aims to elucidate the genetic basis of these wheat cultivars and s...
Single-cell Spatial Multiomics: Technologies, Methods, and Biological Applications [0.03%]
单细胞空间多组学技术、方法及应用研究进展
Dong Xing,Rong Fan,Fangqing Zhao
Dong Xing
Amplification Optimized and Unique Molecular Identifier Guided High Accuracy Full-length CircRNA Sequencing [0.03%]
适用于circRNA全长测序的UMI标记及信号富集优化方法
Yueqi Jin,Xueyan Hu,Yun Zhang et al.
Yueqi Jin et al.
As an emerging important regulatory noncoding RNA, circular RNAs (circRNAs) present significant spatiotemporal expression patterns in a variety of physiological processes and diseases. Thus, accurate identification and quantification of cir...
Fanzhang Lei,Xi Yuan,Qiong Lan et al.
Fanzhang Lei et al.
Over the last two decades, advancements in sequencing technology and data science have significantly deepened the study of transcriptomics, especially non-coding transcriptomics, leading to substantial developments in forensic applications....
The Gap-free Petunia Genome Assemblies Reveal the Evolutionary Dynamics of the S-locus Supergene [0.03%]
间隙互补的矮牵牛基因组揭示了S位点超基因的进化动态
Chen Wang,Hong Zhao,He Wu et al.
Chen Wang et al.
Petunia hybrida is a key genetic model for investigating self-incompatibility (SI), a reproductive barrier governed by the multi-allelic S-locus, which encodes a pistil-specific S-RNase and multiple S-locus F-box (SLF) genes. Due to high he...
Tim Downing
Tim Downing
Pangenome variation graphs (PVGs) allow for the representation of genetic diversity in a more nuanced way than traditional reference-based approaches. Here I focus on how PVGs are a powerful tool for studying genetic variation in viruses, o...