Characterization of Tumor Antigens from Multi-omics Data: Computational Approaches and Resources [0.03%]
基于组学数据的肿瘤抗原表征：计算方法和资源
Yunzhe Wang,James Wengler,Yuzhu Fang et al.
Yunzhe Wang et al.
Tumor-specific antigens, also known as neoantigens, have potential utility in anti-cancer immunotherapy, including immune checkpoint blockade (ICB), neoantigen-specific T cell receptor-engineered T (TCR-T), chimeric antigen receptor T (CAR-...
COCOA: A Framework for Fine-scale Mapping Cell-type-specific Chromatin Compartments with Epigenomic Information [0.03%]
COCOA：一种利用表观遗传信息进行细针准映射细胞类型特异性染色质隔室的框架
Kai Li,Ping Zhang,Jinsheng Xu et al.
Kai Li et al.
Chromatin compartmentalization and epigenomic modification are crucial in cell differentiation and diseases development. However, precise mapping of chromatin compartmental patterns requires Hi-C or Micro-C data at high sequencing depth. Ex...
HemaCisDB: An Interactive Database for Analyzing Cis-Regulatory Elements Across Hematopoietic Malignancies [0.03%]
HemaCisDB：一个用于分析造血恶性肿瘤跨顺式调控元件的交互式数据库
Xinping Cai,Qianru Zhang,Bolin Liu et al.
Xinping Cai et al.
Noncoding cis-regulatory elements (CREs), such as transcriptional enhancers, are key regulators of gene expression programs. Accessible chromatin and H3K27ac are well-recognized markers for CREs associated with their biological function. De...
SCREEN: A Graph-based Contrastive Learning Tool to Infer Catalytic Residues and Assess Enzyme Mutations [0.03%]
基于图的对比学习工具SCREEN用于推断催化残基和评估酶变异的影响
Tong Pan,Yue Bi,Xiaoyu Wang et al.
Tong Pan et al.
The accurate identification of catalytic residues contributes to our understanding of enzyme functions in biological processes and pathways. The increasing number of protein sequences necessitates computational tools for the automated predi...
A Novel Targeted Long-read Sequencing Approach Boosts Transcriptomic Profiling [0.03%]
一种新颖的目标长读测序方法可提升转录组谱分析水平
Xiaolong Tian,Rong Fan
Xiaolong Tian
Harnessing Type II Cytokines to Reinvigorate Exhausted T Cells for Durable Cancer Immunotherapy [0.03%]
利用2型细胞因子重振耗竭T细胞的长期癌症免疫治疗
Wenle Zhang,Yanwen Wang,Bin Li
Wenle Zhang
Mengying Wu,Weilin Pu,Zhenglong Gu
Mengying Wu
Junjie Zhu,Fangqing Zhao
Junjie Zhu
Genome Assembly and Winged fruit Gene Regulation of Chinese Wingnut: Insights from Genomic and Transcriptomic Analyses [0.03%]
中国翅果油树基因组组装及翼果素调控机制研究：基于基因组和转录组分析的见解
Fangdong Geng,Xuedong Zhang,Jiayu Ma et al.
Fangdong Geng et al.
The genomic basis and biology of winged fruit are interesting issues in ecological and evolutionary biology. Chinese wingnut (Pterocarya stenoptera) is an important garden and economic tree species in China. The genomic resources of this ha...
Evaluation of T Cell Receptor Construction Methods from scRNA-Seq Data [0.03%]
基于单细胞 RNA 测序数据的 T 细胞受体构建方法评估
Ruonan Tian,Zhejian Yu,Ziwei Xue et al.
Ruonan Tian et al.
T cell receptors (TCRs) serve key roles in the adaptive immune system by enabling recognition and response to pathogens and irregular cells. Various methods have been developed for TCR construction from single-cell RNA sequencing (scRNA-seq...