MetaDIA: A DDA-free Database Reduction Strategy for DIA Human Gut Metaproteomics [0.03%]
一种无DDA的数据库缩减策略用于人类肠道宏蛋白组中的DIA代谢组学研究
Haonan Duan,Zhibin Ning,Zhongzhi Sun et al.
Haonan Duan et al.
Microbiomes, especially within the gut, are complex and may comprise hundreds of species. The identification of peptides in metaproteomics presents a substantial challenge, as it involves matching peptides to mass spectra within an enormous...
Evaluating AlphaFold Tools and Related Scoring Functions for Protein-peptide Complex Prediction [0.03%]
评估AlphaFold工具及相关打分函数预测蛋白质-肽复合物的能力
Negin Manshour,Jarett Zida Ren,Farzaneh Esmaili et al.
Negin Manshour et al.
Determining the three-dimensional structures of protein-peptide complexes is crucial for elucidating biological processes and designing peptide-based drugs. Protein-peptide docking has become essential for predicting complex structures. Alp...
CD4+ T cells in Type 1 Diabetes: Inferring Stage-specific Dysregulation from scRNA-seq [0.03%]
单细胞RNA测序推断1型糖尿病患者CD4+T细胞的特征性调控变化
Dmitry I Tychinin,Ekaterina S Petriaikina,Olga A Antonova et al.
Dmitry I Tychinin et al.
Deciphering the cellular and molecular mechanisms of type 1 diabetes (T1D) has long been a central goal in immunology. Here, we perform a large-scale single-cell transcriptomic analysis of peripheral blood mononuclear cells from children wi...
Human Single-cell Atlas Analysis Reveals Heterogeneous Endothelial Signaling [0.03%]
人类单细胞图谱分析揭示异质性内皮信号转导
Zimo Zhu,Rongbin Zheng,Yang Yu et al.
Zimo Zhu et al.
Endothelial cells (ECs) play complex roles across tissues and vessel types. Yet, systematic investigations of EC heterogeneity in the combined context of vessel type and tissue microenvironment are still largely lacking. We integrated over ...
Granulin+ Macrophages Promote Lineage Plasticity in Prostate Cancer Through Paracrine Signaling Loops [0.03%]
granulin+巨噬细胞通过旁分泌信号环促进前列腺癌的系谱可塑性
Zhipeng Zhu,Mi Zhang,Ying Song et al.
Zhipeng Zhu et al.
While lineage plasticity is a well-established driver of therapy resistance in prostate cancer, the role of tumor-infiltrating immune cells in mediating phenotype switching remains poorly understood. Here, we employed single-cell multi-omic...
Single-cell RNA Sequencing Discovered Subtypes Associated with Angiogenesis and Propranolol Treatment in Infantile Hemangioma [0.03%]
单细胞RNA测序发现与血管形成和普萘洛尔治疗相关的婴幼儿血管瘤亚型
Qiang Chen,Liuqing Yang,Sili Ni et al.
Qiang Chen et al.
Infantile hemangioma (IH), a benign vascular tumor of infancy, is characterized by rapid postnatal growth and subsequent spontaneous resolution. Although propranolol, initially developed for cardiovascular disorders, is the primary treatmen...
The 2025 Westlake Autumn Symposium for Al Proteomics and Virtual Cell [0.03%]
2025西湖秋季单原子蛋白组学和虚拟细胞研讨会
Rui Sun,Ruedi Aebersold,Qi Xiao et al.
Rui Sun et al.
Comprehensive Epitranscriptome Analysis from MeRIP-seq Data with exomePeak2 [0.03%]
利用exomePeak2从MeRIP-seq数据进行全面的表转录组分析
Jingxian Zhou,Zhen Wei,Di Zhen et al.
Jingxian Zhou et al.
As the most abundant internal RNA modification, N 6-methyladenosine (m6A) affects the fate of RNA through various mechanisms and regulates essential biological processes. In this study, we developed exomePeak2, a novel computational tool fo...
Toward A Pre-disease State-centered New Paradigm in Multi-omics Research [0.03%]
迈向多组学研究的以疾病前期状态为中心的新范式
Cheng Lu,Yan Li,Quansheng Du
Cheng Lu
Integrated multi-omics approaches have fundamentally redefined investigative framework in systems biology and precision medicine. Despite substantial technological progress, precise molecular characterization of pre-disease states remains a...