circASbase：A Comprehensive Database of Alternative Splicing Events in circRNAs [0.03%]
circASbase：含可变剪接事件的环状RNA综合数据库
Lingxiao Zou,Jian Zhao,Haojie Li et al.
Lingxiao Zou et al.
Despite extensive evidence has underscored the critical role of alternative splicing in generating mature circular RNA (circRNA) isoforms and augmenting their function diversity, a significant gap remains in the availability of specialized ...
HGCPep: Hypergraph Deep Learning Identifies Cancer-associated Non-coding Peptides [0.03%]
HGCPep：超图深度学习识别癌症相关非编码肽
Wentao Long,Zhongshen Li,Junru Jin et al.
Wentao Long et al.
A small peptide encoded by a non-coding RNA (ncRNA), known as a non-coding peptide (ncPEP), is emerging as a critical regulator and biomarker in cancer, holding immense promise for immunotherapy. However, systematic identification of ncPEPs...
Bioinformatics Portal for Predicting Binding Regions and Modes in Protein-Nucleic Acid Interactions [0.03%]
预测蛋白质-核酸相互作用结合区域和模式的生物信息学平台
Xiao Zhang,Wenbo Guo,Jiaxin Liu et al.
Xiao Zhang et al.
Protein-nucleic acid interactions (PNIs) are essential for biological processes, including gene regulation, DNA repair, and viral infection. The changes in binding regions and modes in PNIs are vital for understanding the action mechanism a...
CanID: A Robust and Accurate RNA-seq Expression-based Diagnostic Classification Scheme for Pediatric Malignancies [0.03%]
基于RNA序列表达的儿童恶性肿瘤稳健且准确的诊断分类方案CanID
Daniel K Putnam,Alexander M Gout,Delaram Rahbarinia et al.
Daniel K Putnam et al.
Cancer subtype classification is critical for precision therapy and there is a growing trend of augmenting histopathology testing procedures with omics-based machine learning classifiers. However, analytical challenges remain for pediatric ...
Deep Transfer Learning Links Benign Glands to Prostate Cancer Progression via Transcriptomics [0.03%]
基于转录组的深度迁移学习通过转录组学将良性腺体与前列腺癌进程联系起来
Justin L Couetil,Ziyu Liu,Chao Chen et al.
Justin L Couetil et al.
The field effect describes the phenomena where environmental exposures, infection, and genetic predisposition result in molecular changes in cells that predispose them to developing cancer. Though this is a well-established concept in patho...
Noise2read: Accurately Rectify Millions of Erroneous Short Reads Through Graph Learning on Edit Distances [0.03%]
利用编辑距离图学习准确修正数以百万计的错误短读段噪声阅读（Noise2read）
Pengyao Ping,Shuquan Su,Xinhui Cai et al.
Pengyao Ping et al.
Although the per-base error rate of short-read sequencing data is very low at 0.1%-0.5%, the percentage/probability of erroneous reads in a dataset can be as high as 10%-15% or in the number millions. As current methods correct only some er...
Harnessing Large Cohorts and AI to Bridge Genomic Discovery and Clinical Practice [0.03%]
利用大型队列和人工智能弥合基因组学发现与临床实践之间的差距
Bitao Zhong,Shaoqi Wang,Xiaoxi Jing et al.
Bitao Zhong et al.
A Telomere-to-Telomere Diploid Reference Genome and Centromere Structure of the Chinese Quartet [0.03%]
中国四倍体基因组计划——telomere-to-telomere完整 diploid 基因组和染色体着丝粒结构解析
Bo Wang,Peng Jia,Stephen J Bush et al.
Bo Wang et al.
Recent advances in sequencing technologies have enabled the complete assembly of human genomes from telomere to telomere (T2T), resolving previously inaccessible regions such as centromeres and segmental duplications. Here, we present an up...
DBP: Adaptive and Interpretable Factor Analysis for Single-cell RNA-seq Data with Deep Beta Processes [0.03%]
基于深度贝塔过程的单细胞RNA测序数据自适应可解释因子分析(DBP)
Runyan Liu,Shuofeng Hu,Guohua Dong et al.
Runyan Liu et al.
Factor analysis is a method that condenses multiple variables into a few latent factors. It can be used to extract the underlying sources of biological variation in high-dimensional data and distill them into interpretable gene programs. Ho...
Regulation of Alternative Polyadenylation Events by PABPC1 Affects Erythroid Progenitor Cell Expansion [0.03%]
PABPC1通过调控选择性多聚腺苷酸化事件影响红系祖细胞增殖
Yanan Li,Yanbo Yang,Bin Hu et al.
Yanan Li et al.
Erythropoiesis is precisely regulated by multilayered networks. It is crucial for maintaining steady-state hemoglobin levels and ensuring effective oxygen transport. Alternative polyadenylation (APA) is a post-transcriptional regulatory mec...