Siqi Li,Shuwei Li,Siqi Liu et al.
Siqi Li et al.
Mass spectrometry-based single cell proteomics (MS-SCP) is attracting tremendous attention because it is now technically feasible to quantify thousands of proteins in minute samples. Since protein amplification is still not possible, techno...
The Updated Genome Warehouse: Enhancing Data Value, Security, and Usability to Address Data Expansion [0.03%]
更新的基因组仓库：增强数据价值、安全性和易用性以应对数据扩张
Yingke Ma,Xuetong Zhao,Yaokai Jia et al.
Yingke Ma et al.
The Genome Warehouse (GWH), accessible at https://ngdc.cncb.ac.cn/gwh, is an extensively utilized public repository dedicated to the deposition, management and sharing of genome assembly sequences, annotations, and metadata. This paper high...
Deconer: An Evaluation Toolkit for Reference-based Deconvolution Methods Using Gene Expression Data [0.03%]
Deconer：使用基因表达数据评估基于参考的去卷积方法的工具包
Wei Zhang,Xianglin Zhang,Qiao Liu et al.
Wei Zhang et al.
In recent years, computational methods for quantifying cell type proportions from transcription data have gained significant attention, particularly those reference-based methods which have demonstrated high accuracy. However, there is curr...
NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication [0.03%]
NSUN2介导的HCV RNA m5C甲基化促进病毒RNA稳定性和复制
Zhu-Li Li,Yan Xie,Yafen Wang et al.
Zhu-Li Li et al.
RNA modifications have emerged as new efficient targets against viruses. However, little is known about 5-methylcytosine (m5C) modification in the genomes of Flaviviruses. Herein, we demonstrate that hepatitis C virus (HCV), dengue virus, a...
Resolving Leukemia Heterogeneity and Lineage Aberrations with HematoMap [0.03%]
使用HematoMap解决白血病异质性和系别异常问题
Yuting Dai,Wen Ouyang,Wen Jin et al.
Yuting Dai et al.
Precise mapping of leukemic cells onto the known hematopoietic hierarchy is important for understanding the cell-of-origin and mechanisms underlying disease initiation and development. However, this task remains challenging because of the h...
FarmGTEx TWAS-server: An Interactive Web Server for Customized TWAS Analysis [0.03%]
FarmGTEx TWAS服务器：定制TWAS分析的交互式网络服务器
Zhenyang Zhang,Zitao Chen,Jinyan Teng et al.
Zhenyang Zhang et al.
Transcriptome-wide association study (TWAS) is a powerful approach for investigating the molecular mechanisms linking genetic loci to complex phenotypes. However, the complexity of the TWAS analytical pipeline including the construction of ...
Living on the Rocks: Genomic Analysis of Limestone Langurs Provides Novel Insights into the Adaptive Evolution in Extreme Karst Environments [0.03%]
洞穴生存记—— limestone叶猴基因组分析揭示极端喀斯特环境下的适应性进化新见解
Liu Zhijin,Xiongfei Zhang,Peipei Wang et al.
Liu Zhijin et al.
Understanding how organisms adapt to their environments is a central question in evolutionary biology. Limestone langurs are unique among primates, as they are exclusively found in karst limestone habitats and have evolved mechanisms to tol...
Bo Wang,Peng Jia,Shenghan Gao et al.
Bo Wang et al.
Recent developments in PacBio high-fidelity (HiFi) sequencing technologies have transformed genomic research, with circular consensus sequencing now achieving 99.9% accuracy for long (up to 25 kb) single-molecule reads. This method circumve...
Identification of Small Open Reading Frame Encoded Proteins from the Human Genome [0.03%]
人类基因组小开放阅读框编码蛋白的鉴定
Hitesh Kore,Satomi Okano,Keshava K Datta et al.
Hitesh Kore et al.
One of the main goals of human genome project was to identify all the protein-coding genes. There are ∼ 20,500 protein-coding genes annotated in human reference databases. However, in the last few years, proteogenomics studies have predict...
HemaScope: A Tool for Analyzing Single-cell and Spatial Transcriptomics Data of Hematopoietic Cells [0.03%]
HemaScope：一个用于分析造血细胞单细胞和空间转录组数据的工具
Zhenyi Wang,Yuxin Miao,Hongjun Li et al.
Zhenyi Wang et al.
Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) techniques hold great value in evaluating the heterogeneity and spatial characteristics of hematopoietic cells within tissues. These two techniques are highly complemen...