Comprehensive Benchmarking with Guidelines for Analyzing Transposable Element-derived RNA Expression [0.03%]
全面基准测试及分析转座子衍生RNA表达的指导方针
Jianqi She,Jiadong Wang,Ence Yang
Jianqi She
Transposable element-derived RNAs (teRNAs) have been recognized to play accelerating fundamental or pathogenic roles, especially in humans. Despite the rapid development of computational methods, the best practice for accurate identificatio...
Spatial Visual Proteomics: Insights into Tumor Microenvironment Dynamics [0.03%]
空间视觉蛋白质组学：肿瘤微环境动态的见解
Peiwu Huang,Changying Fu,Qian Kong et al.
Peiwu Huang et al.
The tumor microenvironment, a dynamic network of cancer, immune, stromal, and extracellular matrix components, dictates tumor progression and therapeutic resistance. Traditional proteomics, while informative, homogenizes tissues, obscuring ...
ML-Powered MultiFluid-mRNAplex31: A Self-Developed Panel for Precise Tracing of Five Body Fluids [0.03%]
一种用于精准鉴别五种人体检材的机器学习助力多检材mRNAplex（v2.0）体系构建及检案验证
Meiming Cai,Qiong Lan,Man Chen et al.
Meiming Cai et al.
Identification of body fluid origin at crime scenes can help establish a link between the individual who sheds the sample and the criminal activity, thereby aiding the characterization of the case. Many studies have shown that messenger RNA...
HiMWA: A Hierarchical Multiple-wave Admixture Model for Reconstructing Complex Population Admixture Histories [0.03%]
HiMWA：一种用于重建复杂人群混合历史的分层多波混合模型
Yuhan Yang,Rui Zhang,Lu Yang et al.
Yuhan Yang et al.
Population admixture is a pivotal evolutionary process that has profoundly shaped genetic diversity and population structure in modern human populations. However, most existing methods for inferring admixture history rely on simplified assu...
NetCF: A Network Control-based Framework to Reveal the Molecular Mechanism of Phenotype Switching in Lung Cancer [0.03%]
基于网络调控的框架揭示肺癌表型转换的分子机制
Namhee Kim,Jongwan Kim,Jaeog Jeon et al.
Namhee Kim et al.
While targeted therapies are widely used in cancer treatment with specific biomarkers, they still encounter critical challenges such as intrinsic drug resistance. Discovery of combination targets to overcome such resistance is crucial. Howe...
Integrative Genomic and Epigenomic Dissection of Facial Morphology in Chinese Populations [0.03%]
中国人群中面部形态的基因组和表观基因组综合分析
Yongqiang Kong,Lixin Zou,Yiru Zhao et al.
Yongqiang Kong et al.
Facial morphology is a highly heritable human trait, yet its underlying genetic architecture remains largely unresolved despite recent progress from genome-wide association studies (GWAS). Here, we integrated univariate and multivariate ana...
A Spatially Resolved Atlas of Alternative Polyadenylation Across 18 Human Tissues and 76 Disease States [0.03%]
健康和患病组织中差异poly(A)位点的分布图谱
Zehang Jiang,Zhuochao Min,Zhanying Wu et al.
Zehang Jiang et al.
Alternative polyadenylation (APA) is a key regulator of gene expression and cellular dynamics, yet systematic investigations of spatially resolved APA across diverse human tissues remain limited. Here, we developed SpatialAPA (https://githu...
dbPTH: A Comprehensive Database for Protein Targets of Herbal Ingredients [0.03%]
dbPTH：药用活性成分作用蛋白质靶标综合数据库
Jianzhen Peng,Xinhe Huang,Kuo Yang et al.
Jianzhen Peng et al.
The identification of herbal ingredient-target interactions (ITIs) is essential for understanding the molecular basis of herbal pharmacology and facilitating target discovery in drug development. Here, we report a comprehensive database for...
The MAGIC Cohort Study: Genetic Associations of Anisometropia in Chinese Population [0.03%]
MAGIC队列研究：中国人群屈光参差的遗传关联分析
Zhen Ji Chen,Riyan Zhang,Huimin Wu et al.
Zhen Ji Chen et al.
Myopia, particularly high myopia (HM), represents a critical global public health issue due to its strong association with irreversible visual impairment. While past genetic studies have identified numerous myopia-associated loci, they expl...
Improving Genetic Risk Prediction of CAD in Chinese by Multi-ancestry and Multi-trait GWAS Integration [0.03%]
通过多祖先和多性状GWAS整合提高对中国人冠心病遗传风险预测的能力
Huihui Wang,Jinran Lin,Xingjie Hao et al.
Huihui Wang et al.
While many polygenic risk scores (PRSs) of coronary artery disease (CAD) have been developed to stratify disease risks in Europeans, their performances in the Chinese population are suboptimal due to population heterogeneity. Considering th...