PlateletBase: A Comprehensive Knowledgebase for Platelet Research and Disease Insights [0.03%]
PlateletBase：血小板研究和疾病洞察的全面知识库
Huaichao Luo,Changchun Wu,Sisi Yu et al.
Huaichao Luo et al.
Platelets are vital in many pathophysiological processes, yet there is a lack of a comprehensive resource dedicated specifically to platelet research. To fill this gap, we have developed PlateletBase, a knowledge base aimed at enhancing the...
Plasma Proteomic Profiling Reveals ITGA2B as A Key Regulator of Heart Health in High-altitude Settlers [0.03%]
血浆蛋白质组分析揭示ITGA2B在高原定居者心脏健康中的重要作用
Yihao Wang,Pan Shen,Zhenhui Wu et al.
Yihao Wang et al.
Myocardial injury is a common disease in the plateau, especially in the lowlanders who have migrated to the plateau, in which the pathogenesis is not well understood. Here, we established a cohort of lowlanders comprising individuals from b...
Glycolysis Induces Abnormal Transcription Through Histone Lactylation in T-lineage Acute Lymphoblastic Leukemia [0.03%]
糖酵解通过组蛋白乳酸化在T细胞急性淋巴细胞白血病中诱导异常转录
Wenyan Wu,Jingyi Zhang,Huiying Sun et al.
Wenyan Wu et al.
The Warburg effect, which excessively produce lactate, and transcriptional dysregulation are two hallmarks of tumors. However, the precise influence of lactate on epigenetic modifications at a genome-wide level and its impact on gene transc...
Cell-free DNA Fragmentomics Assay to Discriminate the Malignancy of Breast Nodules and Evaluate Treatment Response [0.03%]
无细胞DNA片段组学鉴别乳腺结节良恶性及评估治疗效果的检测方法
Jiaqi Liu,Yalun Li,Wanxiangfu Tang et al.
Jiaqi Liu et al.
The fragmentomics-based cell-free DNA (cfDNA) assays have recently illustrated prominent abilities to identify various cancers from non-conditional healthy controls, while their accuracy for identifying early-stage cancers from benign lesio...
Clonal Hematopoietic Mutations in Plasma Cell Disorders: Clinical Subgroups and Shared Pathogenesis [0.03%]
浆细胞障碍中的克隆性血液肿瘤突变：临床分组与共同的发病机制
Xuezhu Wang,Liping Zuo,Yanying Yu et al.
Xuezhu Wang et al.
Plasma cell disorders (PCDs) are marked by the clonal proliferation of abnormal plasma cells and bone marrow plasma cells (BMPCs), causing various clinical complications. These PCDs include subtypes with distinct clinical features. Multiple...
Zhixin Kang,Tongtong Zhu,Dong Zou et al.
Zhixin Kang et al.
Advancements in high-throughput omics technologies have facilitated a systematic exploration of crucial hematopoietic organs across diverse species. A thorough understanding of hematopoiesis in vivo and facilitation of generating functional...
Harnessing the Foundation Model for Exploration of Single-cell Expression Atlases in Plants [0.03%]
利用基础模型探索植物单细胞表达图谱
Guangshuo Cao,Haoyu Chao,Wenqi Zheng et al.
Guangshuo Cao et al.
Single-cell RNA sequencing (scRNA-seq) provides unprecedented insights into plant cellular diversity by enabling high-resolution analyses of gene expression at the single-cell level. However, the complexity of scRNA-seq data, including chal...
LCORL and STC2 Variants Increase Body Size and Growth Rate in Cattle and Other Animals [0.03%]
LCORL和STC2基因变异使牛和其他动物增大体型并加快生长速度
Fengting Bai,Yudong Cai,Min Qi et al.
Fengting Bai et al.
Natural variants can significantly improve growth traits in livestock and serve as safe targets for gene editing, thus being applied in animal molecular designed breeding. However, such safe and large-effect mutations are severely lacking. ...
The High Expression of PD-1 Defines A Subpopulation of Tfh Cells Responding to COVID-19 Vaccine in Humans [0.03%]
PD-1的高表达定义了对COVID-19疫苗有反应的人群中的Tfh细胞亚群
Jingxin Guo,Zhangfan Fu,Yi Zhang et al.
Jingxin Guo et al.
Inactivated coronavirus disease 2019 (COVID-19) vaccines and receptor binding domain subunit (RBD-subunit) booster vaccination can induce effective humoral immune response. CD4+ T helper cells are essential in helping B cells and antibody r...
High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras [0.03%]
基因组和泛基因组时代的高质量人群特异性单倍型解析参考面板
Qingxin Yang,Yuntao Sun,Shuhan Duan et al.
Qingxin Yang et al.
Large-scale international and regional human genomic and pangenomic resources derived from population-scale biobanks and ancient DNA sequences have provided significant insights into human evolution and the genetic determinants of complex d...