Characterization of Chronic Lymphocytic Leukemia Immunoglobulin Rearrangements from Partial Read Sequencing [0.03%]
基于部分读测序的慢性淋巴细胞白血病免疫球蛋白重排的特征分析
Azahara Fuentes-Trillo,Alicia Serrano-Alcalá,Blanca Ferrer-Lores et al.
Azahara Fuentes-Trillo et al.
The determination of the mutational status in the immunoglobulin variable region is an established prognostic biomarker for chronic lymphocytic leukemia (CLL). The length and inner variability of the variable, diversity, and joining (VDJ) r...
Fuhong He,Zhaojun Zhang,Xiangdong Fang et al.
Fuhong He et al.
Identifying Leukemia-related Genes based on Time-series Dynamical Network by Integrating Differential Genes [0.03%]
基于时间序列动态网络的集成差异基因法的白血病相关基因识别方法
Jin A,Ju Xiang,Xiangmao Meng et al.
Jin A et al.
Leukemia is a malignant disease of progressive accumulation characterized by high morbidity and mortality rates, and investigating its disease genes is crucial for understanding its etiology and pathogenesis. Network propagation methods hav...
Integrative Genome-wide Association Meta-analysis of Aortic Aneurysm and Dissection Identifies Five Novel Genes [0.03%]
主动脉瘤和夹层的全基因组整合Meta分析鉴定出五个新的易感基因
Yifan Du,Yunlong Guan,Zhonghe Shao et al.
Yifan Du et al.
Aortic aneurysm and dissection (AAD) is a multifaceted condition characterized by significant genetic predisposition and a considerable contribution to cardiovascular-related mortality. Previous studies have suggested that AAD subtypes shar...
UNISOM: Unified Somatic Calling and Machine Learning-based Classification Enhance the Discovery of CHIP [0.03%]
UNISOM：统一体细胞突变调用和基于机器学习的分类提高CHIP突变发现能力
Shulan Tian,Garrett Jenkinson,Alejandro Ferrer et al.
Shulan Tian et al.
Clonal hematopoiesis (CH) of indeterminate potential (CHIP), driven by somatic mutations in leukemia-associated genes, confers increased risk of hematologic malignancies, cardiovascular disease, and all-cause mortality. In blood of healthy ...
Integrated Computational and Functional Screening Identify G9a Inhibitors for SETD2-Mutant Leukemia [0.03%]
整合计算和功能筛选识别G9a抑制剂以治疗SETD2突变型白血病
Ya Zhang,Mengfang Xia,Zhenyi Yi et al.
Ya Zhang et al.
SETD2, a frequently mutated epigenetic tumor suppressor in acute leukemia, is associated with chemotherapy resistance and poor patient outcomes. To explore potential therapeutics for SETD2-mutant leukemia, we employed an integrated approach...
The Pathogen Adaptation of HLA Alleles and the Correlation with Autoimmune Diseases in the Han Chinese [0.03%]
汉族人HLA等位基因的病原适应及其与自身免疫疾病的关联研究
Shuai Liu,Yanyan Li,Tingrui Song et al.
Shuai Liu et al.
Human leukocyte antigen (HLA) genes play a crucial role in the adaptation of human populations to the dynamic pathogenic environment. Despite their significance, investigating the pathogen-driven evolution of HLAs and the implications for a...
Xuejing Zhang,Dongyuan Ma,Feng Liu
Xuejing Zhang
The discovery and iteration of clustered regularly interspaced short palindromic repeats (CRISPR) systems have revolutionized genome editing due to their remarkable efficiency and easy programmability, enabling precise manipulation of genom...
TRAIT: A Comprehensive Database for T-cell Receptor-Antigen Interactions [0.03%]
TRAIT：T细胞受体-抗原互作综合数据库
Mengmeng Wei,Jingcheng Wu,Shengzuo Bai et al.
Mengmeng Wei et al.
Comprehensive and integrated resources on interactions between T-cell receptors (TCRs) and antigens are still lacking for adoptive T-cell-based immunotherapies, highlighting a significant gap that must be addressed to fully comprehend the m...
GCRP: Integrated Global Chicken Reference Panel from 11,951 Chicken Genomes [0.03%]
GCRP：来源于11,951份家鸡基因组的综合全球鸡参考面板
Di Zhu,Yuzhan Wang,Hao Qu et al.
Di Zhu et al.
Chickens are a crucial source of protein for humans and a popular model animal for bird research. Despite the emergence of imputation as a reliable genotyping strategy for large populations, the lack of a high-quality chicken reference pane...