A Global Structural Variation Map Reveals Novel Variants for Body Conformation and Racing Ability in Horses [0.03%]
绘制全球结构变异图揭示了影响马身体形态和赛跑能力的新突变
Ying Gong,Xuexue Liu,Zhuqing Zheng et al.
Ying Gong et al.
The selection of horses has been instrumental in shaping long-range mobility, advancing warfare strategies, and diversifying equine phenotypes. However, the structural variants (SVs) favored by this process remain largely unexplored. Utiliz...
Yulun Wu,Tao Jiang,Bo Zhu et al.
Yulun Wu et al.
Antitumor immunity depends on a self-reinforcing cancer-immunity cycle, yet many tumors evade critical steps and respond poorly to checkpoint blockade. Emerging evidence indicates that gut microbiota-derived systemic cues could influence th...
Integrated Single-cell Proteomic and Transcriptomic Landscape of Mouse Folliculogenesis [0.03%]
小鼠卵泡发生的单细胞蛋白质组和转录组图谱整合分析
Hongchao Li,Xinshuai Zhang,Huimin Kang et al.
Hongchao Li et al.
Folliculogenesis is a complex process essential to female fertility, characterized by multifaceted communication between oocytes and granulosa cells (GCs). While transcriptional regulation during folliculogenesis has been extensively studie...
MicroWorldOmics: All-in-one Desktop Solution for Microbiome Profiling, Virome Analysis, and Unexplored "Dark Matter" Discovery [0.03%]
MicroWorldOmics：一站式桌面解决方案，用于微生物组分析、噬菌体研究和未知“暗物质”发现
Runze Li,Wei Dong,Zhuang Yang et al.
Runze Li et al.
The large amount of high-throughput sequencing data generated in ecology, medicine, and pharmacology has increased the complexity of data analysis and interpretation. However, the microbiome and virome fields still lack a user-friendly and ...
Pangenome Graph Reveals the Structural Variation Landscape in 2929 Cattle Samples and Its Impact on Gene Regulation [0.03%]
泛基因组图谱揭示了2929个 cattle 样本中的结构变异景观及其对基因调控的影响
Pengju Zhao,Chen Peng,Yahui Gao et al.
Pengju Zhao et al.
Structural variations (SVs) represent a significant source of genomic diversity, with demonstrated roles in livestock gene expression and traits. However, a comprehensive understanding of the SV landscape across large sample sets and its im...
SAA1 Promotes Pro-inflammatory Macrophage-mediated Bone Invasion in Silent Corticotroph Adenomas [0.03%]
SAT1促进无功能性促肾上腺皮质激素腺瘤中促炎巨噬细胞介导的骨侵犯作用
Jingyuan Jia,Chenggang Jiang,Jindou Xie et al.
Jingyuan Jia et al.
Silent corticotroph adenomas (SCAs) represent a high-risk subtype of pituitary neuroendocrine tumors, characterized by significant clinical heterogeneity and unclear pathogenesis. The multimicrocystic sign is a typical radiological feature ...
High Mutation Rates in Non-human Primates Edited by Cytosine Base Editors [0.03%]
次黄嘌呤碱基编辑器会导致非人灵长类动物中的高突变率
Wenwen Shi,Shao-Jie Zhang,Wushuang Rui et al.
Wenwen Shi et al.
Gene-edited animals are being produced and used in ever-increasing numbers. However, their genome-wide mutation rates remain largely unknown. To characterize the mutation rates in animals edited by different gene editors, we analysed the pu...
NTM-DB: A Comprehensive Non-tuberculosis Mycobacteria Genomic Database [0.03%]
NTM-DB：全面的非结核分枝杆菌基因组数据库
Tianyi Lu,Cuidan Li,Haobin Wei et al.
Tianyi Lu et al.
Non-tuberculous mycobacteria (NTM) are a major group of environmental bacteria, approximately one-third of which cause serious human infections, particularly respiratory diseases. The global rise in the prevalence and severity of NTM infect...
TNEAtlas: A Pan-cancer Database to Identify and Characterize Transcribed Non-coding Elements [0.03%]
TNEAtlas：一个用于识别和表征转录的非编码元件的泛癌症数据库
Wenyong Zhu,Rongxin Zhang,Xiao Sun
Wenyong Zhu
Advances in precision oncology have underscored the need to move beyond regulatory frameworks centered on protein-coding regions and better understand regulatory mechanisms within the non-coding genome. To systematically characterize transc...
Single-cell RNA Sequencing Reveals A Tumor-Promoting Role of EGR1+CD4+ T Cells in Papillary Thyroid Cancer [0.03%]
单细胞RNA测序揭示EGR1+CD4+ T细胞在乳头状甲状腺癌中的促肿瘤作用
Zhengshi Wang,Yun Zhang,Yong Xu et al.
Zhengshi Wang et al.
Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Based on single-cell RNA sequencing, a previously unrecognized CD4+ T cell subset was identified, termed EGR1+CD4+ T cells. This subset produced high levels of IL-10 and ...