My journey to DNA repair [0.03%]
我与DNA修复的不解之缘
Tomas Lindahl
Tomas Lindahl
I completed my medical studies at the Karolinska Institute in Stockholm but have always been devoted to basic research. My longstanding interest is to understand fundamental DNA repair mechanisms in the fields of cancer therapy, inherited h...
MeRIP-PF: an easy-to-use pipeline for high-resolution peak-finding in MeRIP-Seq data [0.03%]
MeRIP-PF：一个用于MeRIP-seq数据高分辨率峰查找的简便流水线
Yuli Li,Shuhui Song,Cuiping Li et al.
Yuli Li et al.
RNA modifications, especially methylation of the N(6) position of adenosine (A)-m(6)A, represent an emerging research frontier in RNA biology. With the rapid development of high-throughput sequencing technology, in-depth study of m(6)A dist...
Global genomic arrangement of bacterial genes is closely tied with the total transcriptional efficiency [0.03%]
全局基因组排列与细菌基因的总转录效率密切相关
Qin Ma,Ying Xu
Qin Ma
The availability of a large number of sequenced bacterial genomes allows researchers not only to derive functional and regulation information about specific organisms but also to study the fundamental properties of the organization of a gen...
Identification of candidate transcription factor binding sites in the cattle genome [0.03%]
家畜基因组中候选转录因子结合位点的鉴定
Derek M Bickhart,George E Liu
Derek M Bickhart
A resource that provides candidate transcription factor binding sites (TFBSs) does not currently exist for cattle. Such data is necessary, as predicted sites may serve as excellent starting locations for future omics studies to develop tran...
The history and advances of reversible terminators used in new generations of sequencing technology [0.03%]
新一代测序技术中可逆终止子的应用进展及研究现状
Fei Chen,Mengxing Dong,Meng Ge et al.
Fei Chen et al.
DNA sequencing using reversible terminators, as one sequencing by synthesis strategy, has garnered a great deal of interest due to its popular application in the second-generation high-throughput DNA sequencing technology. In this review, w...
Zhang Zhang,Jun Yu
Zhang Zhang
In the RNA world, RNA is assumed to be the dominant macromolecule performing most, if not all, core "house-keeping" functions. The ribo-cell hypothesis suggests that the genetic code and the translation machinery may both be born of the RNA...
Interactome mapping: using protein microarray technology to reconstruct diverse protein networks [0.03%]
互作组研究：利用蛋白质微阵列技术重构多种蛋白质网络
Ijeoma Uzoma,Heng Zhu
Ijeoma Uzoma
A major focus of systems biology is to characterize interactions between cellular components, in order to develop an accurate picture of the intricate networks within biological systems. Over the past decade, protein microarrays have greatl...
Shigella strains are not clones of Escherichia coli but sister species in the genus Escherichia [0.03%]
志贺氏菌不是大肠杆菌的克隆而是结肠杆菌属的大姐物种
Guanghong Zuo,Zhao Xu,Bailin Hao
Guanghong Zuo
Shigella species and Escherichia coli are closely related organisms. Early phenotyping experiments and several recent molecular studies put Shigella within the species E. coli. However, the whole-genome-based, alignment-free and parameter-f...
DNA barcode ITS effectively distinguishes the medicinal plant Boerhavia diffusa from its adulterants [0.03%]
DNA条形码有效地区分差巴戟天及其伪品植物
Dhivya Selvaraj,Dhivya Shanmughanandhan,Rajeev Kumar Sarma et al.
Dhivya Selvaraj et al.
Boerhavia diffusa (B. diffusa), also known as Punarnava, is an indigenous plant in India and an important component in traditional Indian medicine. The accurate identification and collection of this medicinal herb is vital to enhance the dr...
Mohd Danishuddin,Lalima Kaushal,Mohd Hassan Baig et al.
Mohd Danishuddin et al.
Drug resistance is one of the major concerns for antimicrobial chemotherapy against any particular target. Knowledge of the primary structure of antimicrobial agents and their activities is essential for rational drug design. Thus, we devel...