MethylGenotyper: Accurate Estimation of SNP Genotypes and Genetic Relatedness from DNA Methylation Data [0.03%]
甲基化基因分型：从DNA甲基化数据中准确估计SNP基因型和遗传关系
Yi Jiang,Minghan Qu,Minghui Jiang et al.
Yi Jiang et al.
Epigenome-wide association studies (EWAS) are susceptible to widespread confounding caused by population structure and genetic relatedness. Nevertheless, kinship estimation is challenging in EWAS without genotyping data. Here, we proposed M...
AVM: A Manually Curated Database of Aerosol-transmitted Virus Mutations, Human Diseases, and Drugs [0.03%]
AVM：一个关于气溶胶传播病毒突变、人类疾病和药物的人工整理数据库
Lan Mei,Yaopan Hou,Jiajun Zhou et al.
Lan Mei et al.
Aerosol-transmitted viruses possess strong infectivity and can spread over long distances, earning the difficult-to-control title. They cause various human diseases and pose serious threats to human health. Mutations can increase the transm...
BLUPmrMLM: A Fast mrMLM Algorithm in Genome-wide Association Studies [0.03%]
全基因组关联研究中快速的mrMLM算法BLUPmrMLM
Hong-Fu Li,Jing-Tian Wang,Qiong Zhao et al.
Hong-Fu Li et al.
Multilocus genome-wide association study has become the state-of-the-art tool for dissecting the genetic architecture of complex and multiomic traits. However, most existing multilocus methods require relatively long computational time when...
DRED: A Comprehensive Database of Genes Related to Repeat Expansion Diseases [0.03%]
DRED：与重复扩增疾病相关基因的综合数据库
Qingqing Shi,Min Dai,Yingke Ma et al.
Qingqing Shi et al.
Expansion of tandem repeats in genes often causes severe neuromuscular diseases, such as fragile X syndrome, Huntington's disease, and spinocerebellar ataxia. However, information on genes associated with repeat expansion diseases is scatte...
SCancerRNA: Expression at the Single-cell Level and Interaction Resource of Non-coding RNA Biomarkers for Cancers [0.03%]
SCancerRNA：癌症非编码RNA生物标志物的单细胞表达及其互作资源
Hongzhe Guo,Liyuan Zhang,Xinran Cui et al.
Hongzhe Guo et al.
Non-coding RNAs (ncRNAs) participate in multiple biological processes associated with cancers as tumor suppressors or oncogenic drivers. Due to their high stability in plasma, urine, and many other fluids, ncRNAs have the potential to serve...
MSIsensor-RNA: Microsatellite Instability Detection for Bulk and Single-cell Gene Expression Data [0.03%]
MSIsensor-RNA：批量和单细胞基因表达数据微卫星不稳定性检测
Peng Jia,Xuanhao Yang,Xiaofei Yang et al.
Peng Jia et al.
Microsatellite instability (MSI) is an indispensable biomarker in cancer immunotherapy. Currently, MSI scoring methods by high-throughput omics methods have gained popularity and demonstrated better performance than the gold standard method...
RNA 5-Methylcytosine Modification: Regulatory Molecules, Biological Functions, and Human Diseases [0.03%]
RNA 5-甲基胞嘧啶修饰：调控分子、生物学功能及人类疾病
Yanfang Lu,Liu Yang,Qi Feng et al.
Yanfang Lu et al.
RNA methylation modifications influence gene expression, and disruptions of these processes are often associated with various human diseases. The common RNA methylation modification 5-methylcytosine (m5C), which is dynamically regulated by ...
The Genome Architecture of the Copepod Eurytemora carolleeae, the Highly Invasive Atlantic Clade of the E. affinis Species Complex [0.03%]
入侵大西洋的剑水蚤Eurytemora affinis复合物种中高度侵入性的卡罗琳氏无剑水蚤基因组结构
Zhenyong Du,Gregory Gelembiuk,Wynne Moss et al.
Zhenyong Du et al.
Copepods are among the most abundant organisms on the planet and play critical functions in aquatic ecosystems. Among copepods, populations of the Eurytemora affinis species complex are numerically dominant in many coastal habitats and are ...
Whole-genome Sequencing Association Analysis of Quantitative Platelet Traits in A Large Cohort of β-thalassemia [0.03%]
在大型β-地中海贫血队列中进行的血小板数量性状全基因组测序关联分析
Xingmin Wang,Qianqian Zhang,Xianming Chen et al.
Xingmin Wang et al.
Platelet acts as a crucial monitoring indicator for hypercoagulability and thrombosis and a key target for drug regulation. Genotype-phenotype association studies have confirmed that platelet traits are quantitatively regulated by multiple ...
Qianpeng Li,Yang Zhang,Sicheng Luo et al.
Qianpeng Li et al.
An accurate assessment of p53's functional status is critical for cancer genomic medicine. However, there is a significant challenge in identifying tumors with non-mutational p53 inactivations that are not detectable through DNA sequencing....