Satellite-like Gold Nanocomposites for Targeted Mass Spectrometry Imaging of Tumor Tissues [0.03%]
卫星状金纳米复合物用于肿瘤组织靶向质谱成像
Yu-Ting Tseng,Scott G Harroun,Chien-Wei Wu et al.
Yu-Ting Tseng et al.
We have developed a simple, rapid, high-throughput cancer diagnosis system using functional nanoparticles (NPs) consisting of poly(catechin) capped-gold NPs (Au@PC NPs) and smaller nucleolin-binding aptamer (AS1411) conjugated gold NPs (AS1...
Engineering Quantum Dots with Different Emission Wavelengths and Specific Fluorescence Lifetimes for Spectrally and Temporally Multiplexed Imaging of Cells [0.03%]
用于细胞光谱和时间复用成像的不同发射波长和特定荧光寿命的量子点工程学
Butian Zhang,Chengbin Yang,Yuan Gao et al.
Butian Zhang et al.
In this work, a proof-of-concept study was performed to examine the potential of spectrally and temporally multiplexed imaging of cells by using quantum dots (QDs). The CdSe and ZAIS QDs with different emission wavelengths and well-separate...
Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy [0.03%]
用于癌症治疗的肝素调节的前药型大分子诊疗系统
Huiyuan Wang,Cheol Moon,Meong Cheol Shin et al.
Huiyuan Wang et al.
Heparin is a kind of naturally occurring polymer with excellent biocompatibility and solubility. It is characterized by dense of negative charge, higher than any endogenous components. Heparin can bind with various cationic peptides and pro...
A Vascular Permeability Assay Using an In Vitro Human Microvessel Model Mimicking the Inflammatory Condition [0.03%]
一种体外人微血管模型的血管通透性检测方法及其在炎症条件下的应用研究
Joris Pauty,Ryo Usuba,Haruko Takahashi et al.
Joris Pauty et al.
The vascular barrier is an important function of the endothelium and its dysfunction is involved in several diseases. The barrier function of the endothelial cell monolayer is governed by cell-cell, cell-extracellular matrix (cell-ECM) cont...
Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice In Vivo [0.03%]
用于小鼠活体内CD44表达肿瘤的新型透明质酸缀合物的双核成像和治疗研究
Ravindra Dhar Dubey,Rebecca Klippstein,Julie Tzu-Wen Wang et al.
Ravindra Dhar Dubey et al.
Hyaluronic acid, a natural CD44 receptor ligand, has attracted attention in the past years as a macromolecular delivery of anticancer agents to cancer. At the same time, the clinical applications of Gemcitabine (Gem) have been hindered by i...
Upendra Chitgupi,Yiru Qin,Jonathan F Lovell
Upendra Chitgupi
Phototherapies involve the irradiation of target tissues with light. To further enhance selectivity and potency, numerous molecularly targeted photosensitizers and photoactive nanoparticles have been developed. Active targeting typically in...
Effects of Cd-based Quantum Dot Exposure on the Reproduction and Offspring of Kunming Mice over Multiple Generations [0.03%]
Cd基量子点的多代小鼠生殖毒性研究及对子代的影响
Jianwei Liu,Chengbin Yang,Jing Liu et al.
Jianwei Liu et al.
The potential health risks associated with heavy-metal containing quantum dots (QDs) are a major concern accompanying their increased application in both research and industry. In this contribution, we investigate the effects of QDs on repr...
Improving Brain Delivery of Biomolecules via BBB Modulation in Mouse and Rat: Detection using MRI, NIRF, and Mass Spectrometry [0.03%]
利用MRI、近红外和质谱检测改善小鼠和大鼠脑屏障调节下的生物分子脑传递效果
Kavisha R Ulapane,Ngoc On,Paul Kiptoo et al.
Kavisha R Ulapane et al.
There is an urgent need to develop new and alternative methods to deliver functional biomolecules to the brain for diagnosis and treatment of brain diseases. The goal of this study was to evaluate the activity of blood-brain barrier (BBB) m...
Gold Nanoparticle Based Platforms for Circulating Cancer Marker Detection [0.03%]
基于金纳米粒子的循环肿瘤标志物检测平台
Xiaohua Huang,Ryan O&#x;Connor,Elyahb Allie Kwizera
Xiaohua Huang
Detection of cancer-related circulating biomarkers in body fluids has become a cutting-edge technology that has the potential to noninvasively screen cancer, diagnose cancer at early stage, monitor tumor progression, and evaluate therapy re...
Alexandra Sneider,Derek VanDyke,Shailee Paliwal et al.
Alexandra Sneider et al.
Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response, and, if required, initiate secondary treatments. Recent in vivo experiments demonst...