Next-Generation Anticancer Peptides: Engineering, Nanotheranostics and Clinical Translation [0.03%]
下一代抗肿瘤肽：工程学、纳米精准诊治和临床转化
Abhishesh Kumar Mehata,Shinsuke Fukui,Yoshihiro Izumiya
Abhishesh Kumar Mehata
Anticancer peptides (ACPs) have emerged as a transformative class of next-generation therapeutics that bridge molecular precision with multifunctional tunability. Unlike many conventional small molecule chemotherapeutics, ACPs offer intrins...
Molecular Characterization of Factor VIII Gene Variants in Hemophilia A: A Genotype-Haplotype Study from Eastern and Northern-Central India [0.03%]
印度东部和中部地区血友病A因子Ⅷ基因变异的分子特征及基因型-单体型研究
Chanda Hemaliya,Arun Kumar Singh,Anju Bharti et al.
Chanda Hemaliya et al.
Rationale: Hemophilia A is an X-linked recessive bleeding disorder caused by a deficiency or dysfunction of factor VIII (FVIII), affecting approximately 1 in 5,000 males globally, including those in northern India. Accura...
In Vivo Bioimaging and Biodistribution of DiR-Labeled Solid SNEDDS of Black Sticky Rice Extract Using Neusilin® US2 as Solid Carrier [0.03%]
使用Neusilin®US2作为固体载体的黑粘米提取物SolidSNEDDSs的体内成像及分布研究（DiR标记）
Anggun Hari Kusumawati,Elfahmi Elfahmi,Afrillia Nuryanti Garmana et al.
Anggun Hari Kusumawati et al.
Black Sticky Rice Extract (BSRE; Oryza sativa var. glutinosa Blanco) is rich in anthocyanins and flavonoids with well-documented antioxidant and hepatoprotective activities. Nevertheless, its clinical translation is hindered by poor aqueous...
A Glucose-Responsive CeO₂@GOx Nanozyme Embedded in Chitosan/PVA Hydrogel for Accelerated Diabetic Wound Healing: from Molecular Simulations to In Vivo Validation [0.03%]
一种嵌入壳聚糖/PVA水凝胶中的葡萄糖响应型CeO₂@GOx纳米酶，用于加速糖尿病伤口愈合：从分子模拟到体内验证
Lidia Grace Naomi,Dino Pati Putra,Rangga Adhi Prastika et al.
Lidia Grace Naomi et al.
Diabetes prevalence in Indonesia reached 19.465 million patients in 2021 and is predicted to increase to 40.7 million cases by 2045, with 15-25% of diabetic patients at risk of diabetic wounds and 15-30% threatened with amputation. This stu...
A Rapid, High-Resolution Chromatographic Method for Isolating Subpopulations of HEK293-derived Extracellular Vesicles [0.03%]
一种快速高效的色谱法分离HEK293细胞来源的外泌体亚群
Raphael Ewonde Ewonde,William F Pons,R Kenneth Marcus
Raphael Ewonde Ewonde
Rationale: In recent years, significant advances have been made in understanding the basic underlying science of extracellular vesicles (EVs). This has opened multiple avenues for potential application, especially in area...
Liposomal J-Aggregates of Indocyanine Green as a Multifunctional Contrast Agent for Photoacoustic Imaging and Photothermal Therapy [0.03%]
用于光声成像和光热治疗的近红外光染料吲哚青绿liposome包裹J聚集体多功能造影剂研究
Noah Stern,Binita Shrestha,Susan Burrell et al.
Noah Stern et al.
One of the major barriers to further clinical adoption of photoacoustic imaging (PAI) and photothermal therapy (PTT) is a lack of versatile and multi-faceted contrast agents. While indocyanine green (IcG) has gained considerable attention a...
Bioelectronics for In Situ Monitoring of Tumor Microenvironment Markers [0.03%]
用于原位监测肿瘤微环境标志物的生物电子学
Kuldeep Mahato,Girijesh Kumar Patel
Kuldeep Mahato
The tumor microenvironment (TME) is a dynamic and heterogeneous niche that critically shapes cancer progression, immune evasion, and therapeutic resistance. Characterized by gradients in oxygen tension, pH, and metabolic activity, the TME o...
Rapid method for the high purity isolation of bovine milk-derived extracellular vesicles via polyester (PET) capillary-channeled polymer (C-CP) fiber columns [0.03%]
一种通过聚酯(PET)(capillary-channeled聚合物(C-CP)纤维柱高效纯化牛奶外泌体的快速方法
Carolina Mata,R Kenneth Marcus
Carolina Mata
The use of raw bovine milk as a source of extracellular vesicles (EVs) has gained in interest for therapeutic applications due to its low cost, accessibility, low immunogenicity, and potential for oral delivery. To address the need to achie...
Quantification of Kidney Inflammation Using Nanobubble-mediated Contrast Enhanced Ultrasound [0.03%]
纳米气泡增强型对比超声在肾脏炎症量化中的应用
Niloufar Rostam Shirazi,Xiaolin He,Dana Dranka et al.
Niloufar Rostam Shirazi et al.
Kidney inflammation is a central driver of acute kidney injury (AKI) and its progression to chronic kidney disease (CKD). While several imaging and biomarker-based approaches are under development, clinically validated non-invasive methods ...
Expression of BMP-2, OPG, RANKL And Number of Osteoblasts After Application of Bovine Amniotic Membrane and Secretome Umbilical Cord in Wistar Rats [0.03%]
应用牛胎盘羊膜和脐带秘密组分对Wistar大鼠成骨标志物BMP-2、OPG、RANKL的表达及成骨细胞数量的影响
Ernie Maduratna Setiawatie,Lambang Bargowo,Shafira Kurnia Supandi et al.
Ernie Maduratna Setiawatie et al.
Introduction: Bovine amniotic membrane (BAM) and secretome are tissue engineering materials studied for their high healing effects. This study aims to evaluate the expression levels of BMP-2, OPG, RANKL, and osteoblast count following the a...