MnO2-gated Nanoplatforms with Targeted Controlled Drug Release and Contrast-Enhanced MRI Properties: from 2D Cell Culture to 3D Biomimetic Hydrogels [0.03%]
具有靶向控制释放和对比增强MRI性能的MnO2调控纳米平台：从二维细胞培养到三维仿生水凝胶
Yupeng Shi,Flavien Guenneau,Xiaolin Wang et al.
Yupeng Shi et al.
Multifunctional nanomaterials combining diagnosis and therapeutic properties have attracted a considerable attention in cancer research. Yet some important challenges are still to be faced, including an optimal coupling between these two ty...
A Scalable Method for Squalenoylation and Assembly of Multifunctional 64Cu-Labeled Squalenoylated Gemcitabine Nanoparticles [0.03%]
一种可扩展的用于制备多模式放射活性64Cu-标记的Gemcitabine纳米颗粒的方法
Samantha T Tucci,Jai W Seo,Hamilton Kakwere et al.
Samantha T Tucci et al.
Squalenoylation of gemcitabine, a front-line therapy for pancreatic cancer, allows for improved cellular-level and system-wide drug delivery. The established methods to conjugate squalene to gemcitabine and to form nanoparticles (NPs) with ...
Functionalized MoS2 Nanosheets as Multi-Gene Delivery Vehicles for In Vivo Pancreatic Cancer Therapy [0.03%]
用于体内胰腺癌治疗的多功能MoS2纳米片多基因递送载体
Feng Yin,Tommy Anderson,Nishtha Panwar et al.
Feng Yin et al.
Transition metal dichalcogenides (TMDCs) are categorized as novel two-dimensional (2D) nanomaterials with unique physical and chemical properties, bearing varied applications in medical and materials sciences. However, only a few works repo...
In vivo therapeutic evaluation of polymeric nanomedicines: effect of different targeting peptides on therapeutic efficacy against breast cancer [0.03%]
不同靶向肽对治疗乳腺癌的疗效评价研究
Yongmei Zhao,Nicholas L Fletcher,Tianqing Liu et al.
Yongmei Zhao et al.
Targeted nanomedicines offer many advantages over macromolecular therapeutics that rely only on passive accumulation within the tumour environment. The aim of this work was to investigate the in vivo anticancer efficiency of polymeric nanom...
Hyaluronic Acid-Based Optical Probe for the Diagnosis of Human Osteoarthritic Cartilage [0.03%]
用于人类骨关节软骨诊断的透明质酸基光学探针
Shuxin Li,Wei Cong,Amirhossein Hakamivala et al.
Shuxin Li et al.
Osteoarthritis is typically caused by cartilage injury, followed by localized inflammatory responses and tissue deterioration. Early treatment of osteoarthritis is often impossible due to the lack of diagnostic options. Recent studies have ...
Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home? [0.03%]
功能性介孔硅纳米粒子靶向生长抑素受体——命中靶心了吗？
Valeriy M Paramonov,Diti Desai,Helene Kettiger et al.
Valeriy M Paramonov et al.
The concept of delivering nanoformulations to desired tissues by means of targeting membrane receptors of high local abundance by ligands anchored to the nanocarrier has gained a lot of attention over the last decade. Currently, there is no...
Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection [0.03%]
基于富马氧醇的双模态影像探针检测干细胞移植排斥反应
Kai Li,Carmel T Chan,Hossein Nejadnik et al.
Kai Li et al.
Purpose: Stem cell transplants are an effective approach to repair large bone defects. However, comprehensive techniques to monitor the fate of transplanted stem cells in vivo are lacking. Such strategies would enable corrective interventio...
Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes [0.03%]
基于局域表面等离子共振的近红外光控阿霉素高效低毒给药体系
Shellie S Knights-Mitchell,Marek Romanowski
Shellie S Knights-Mitchell
Precise control of drug release from nanoparticles can improve efficacy and reduce systemic toxicity associated with administration of certain medications. Here, we combined two phenomena, photothermal conversion in plasmon resonant gold co...
HAase-sensitive dual-targeting irinotecan liposomes enhance the therapeutic efficacy of lung cancer in animals [0.03%]
HA酶敏感的双靶向伊立替康脂质体增强动物模型中肺癌的治疗效果
Liang Zhang,Haixin Cui
Liang Zhang
Among all cancers, lung cancer is one of the most common and serious types of cancer. It is challenging for site-specific delivery of anticancer therapeutics to tumor cells. Herein, we developed a novel"smart" dual-targeting liposomal platf...
Genome-wide Transcriptional Analysis of Oxidative Stress-related Genes and Pathways Induced by CdTe aqQDs in Mice [0.03%]
CdTe量子点诱导小鼠氧化应激相关基因及通路的全基因组转录分析
Ling Kong,Jiayi Li,Jilong Wang et al.
Ling Kong et al.
Objective: Quantum dots (QDs) has widely applied in the field of science, whose potential toxic effect has increasingly become a focus concern we need pay attention to in public health. The purpose of this article was to explore the toxicit...