Enhanced Photothermal Treatment Efficacy and Normal Tissue Protection via Vascular Targeted Gold Nanocages [0.03%]
血管靶向金纳米笼增强光热治疗疗效并保护正常组织
Samir V Jenkins,Dmitry A Nedosekin,Barry J Shaulis et al.
Samir V Jenkins et al.
A major challenge in photothermal treatment is generating sufficient heat to eradicate diseased tissue while sparing normal tissue. Au nanomaterials have shown promise as a means to achieve highly localized photothermal treatment. Toward th...
Perfluorocarbon nanodroplets can reoxygenate hypoxic tumors in vivo without carbogen breathing [0.03%]
无需呼吸 carbogen 的情况下全氟碳纳米液滴能重新供养体内低氧肿瘤细胞
Yun Xiang,Nicholas Bernards,Bryan Hoang et al.
Yun Xiang et al.
Nanoscale perfluorocarbon (PFC) droplets have enormous potential as clinical theranostic agents. They are biocompatible and are currently used in vivo as contrast agents for a variety of medical imaging modalities, including ultrasound, com...
Nanomedicine-Assisted Combination Therapy of NSCLC: New Platinum-Based Anticancer Drug Synergizes the Therapeutic Efficacy of Ganetespib [0.03%]
纳米医学辅助的非小细胞肺癌联合疗法：新型铂基抗肿瘤药物增敏Ganetespib治疗效果
Jyothi Kallu,Tuhina Banerjee,Shoukath Sulthana et al.
Jyothi Kallu et al.
Purpose: K-RAS is the most common mutated oncogene associated with Non-Small-Cell Lung Cancer (NSCLC). So far, there are no promising chemotherapies for the direct inhibition of K-RAS, and considered to be undruggable. In this work, we have...
Alkyne- and Nitrile-Anchored Gold Nanoparticles for Multiplex SERS Imaging of Biomarkers in Cancer Cells and Tissues [0.03%]
用于癌细胞和组织中生物标志物多重SERS成像的乙炔基和腈基锚定型金纳米粒子
Mingmin Li,Jianzhen Wu,Mengtian Ma et al.
Mingmin Li et al.
Surface-enhanced Raman spectroscopy (SERS) has proven a powerful tool for multiplex detection and imaging due to its narrow peak width and high sensitivity. However, conventional SERS reporters are limited to thiolated compounds, which have...
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model [0.03%]
卡巴他赛联合血脑屏障开启在患者来源的胶质母细胞瘤模型中的治疗效果
Einar Sulheim,Yrr Mørch,Sofie Snipstad et al.
Einar Sulheim et al.
Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, a semi-synthetic...
Laparoscopic fluorescence image-guided photothermal therapy enhances cancer diagnosis and treatment [0.03%]
腹腔镜荧光图像引导的光热疗法可提高癌症诊断和治疗效果
Mohan Singh,Elham Nabavi,Yu Zhou et al.
Mohan Singh et al.
Endoscopy is the gold standard investigation in the diagnosis of gastrointestinal cancers and the management of early and pre-malignant lesions either by resection or ablation. Recently gold nanoparticles have shown promise in cancer diagno...
Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment [0.03%]
纳米颗粒对肿瘤微环境中巨噬细胞极化生物学效应的影响研究
Derek Reichel,Manisha Tripathi,J Manuel Perez
Derek Reichel
Biological interactions between tumor-associated macrophages (TAMs), cancer cells and other cells within the tumor microenvironment contribute to tumorigenesis, tumor growth, metastasis and therapeutic resistance. TAMs can remodel the tumor...
Comparing Semiconductor Nanocrystal Toxicity in Pregnant Mice and Non-Human Primates [0.03%]
比较半导体纳米晶在怀孕小鼠和非人灵长类动物体内的毒性大小
Ling Ye,Rui Hu,Liwei Liu et al.
Ling Ye et al.
Rationale: Despite growing use of engineered nanomaterials (ENM) in applications from electronics to medicine, the potential risk to human health remains a critical concern within clinical use. ENM exposure during pregnancy can potentially ...
Comparative Study
Nanotheranostics. 2019 Jan 1;3(1):54-65. DOI:10.7150/ntno.27452 2019
Intelligent Photosensitive Mesenchymal Stem Cells and Cell-Derived Microvesicles for Photothermal Therapy of Prostate Cancer [0.03%]
用于前列腺癌光热治疗的智能感光间充质干细胞及其细胞衍生微囊泡
Liqun Huang,Chang Xu,Peng Xu et al.
Liqun Huang et al.
Targeted delivery of nanomedicines into the tumor site and improving the intratumoral distribution remain challenging in cancer treatment. Here, we report an effective transportation system utilizing both of mesenchymal stem cells (MSCs) an...
Aswathy Ravindran Girija,Sivakumar Balasubramanian
Aswathy Ravindran Girija
Theragnostics is considered as an emerging treatment strategy that integrates therapeutics and diagnostics thus allowing delivery of therapeutics and simultaneous monitoring of the progression of treatment. Among the different types of inor...