Organ Biodistribution of Radiolabelled γδ T Cells Following Liposomal Alendronate Administration in Different Mouse Tumour Models [0.03%]
载阿仑膦酸钠脂质体的放射性标记γδT细胞在不同小鼠移植瘤模型中的器官分布研究
Julie T-W Wang,Naomi O Hodgins,Wafa&#x; T Al-Jamal et al.
Julie T-W Wang et al.
Vγ9Vδ2 T cell immunotherapy has been shown to be effective in delaying tumour growth in both pre-clinical and clinical studies. It has been pointed out the importance of the ability of cells to accumulate within tumours and the associatio...
Effects of molecular weight and structural conformation of multivalent-based elastin-like polypeptides on tumor accumulation and tissue biodistribution [0.03%]
分子量及多价基序结构构象对弹性蛋白多肽肿瘤聚集及组织内分布的影响研究
Vijaya Sarangthem,Bo-Yeon Seo,Aena Yi et al.
Vijaya Sarangthem et al.
In order to improve clinical outcomes for novel drug delivery systems, distinct optimization of size, shape, multifunctionality, and site-specificity are of utmost importance. In this study, we designed various multivalent elastin-like poly...
Phospholipid prodrug conjugates of insoluble chemotherapeutic agents for ultrasound targeted drug delivery [0.03%]
用于超声靶向药物输送的难溶性化疗药物的磷脂前药共轭物
Mendi G Márquez,Rachel Dotson,Sally Pias et al.
Mendi G Márquez et al.
The hydrophobicity and high potency of many therapeutic agents makes them difficult to use effectively in clinical practice. This work focuses on conjugating phospholipid tails (2T) onto podophyllotoxin (P) and its analogue (N) using a link...
FGF2 engineered SPIONs attenuate tumor stroma and potentiate the effect of chemotherapy in 3D heterospheroidal model of pancreatic tumor [0.03%]
工程化FGF2-SPIONs削弱胰腺肿瘤微环境并增强化疗作用的三维异种球形模型研究
Deby Fajar Mardhian,Aggelos Vrynas,Gert Storm et al.
Deby Fajar Mardhian et al.
Pancreatic ductal adenocarcinoma (PDAC), characterized with abundant tumor stroma, is a highly malignant tumor with poor prognosis. The tumor stroma largely consists of cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM), an...
Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy [0.03%]
放射标记聚合物体在放疗中的摄取和亚细胞分布
Stefan J Roobol,Thomas A Hartjes,Johan A Slotman et al.
Stefan J Roobol et al.
Polymersomes have the potential to be applied in targeted alpha radionuclide therapy, while in addition preventing release of recoiling daughter isotopes. In this study, we investigated the cellular uptake, post uptake processing and intrac...
Thermo-responsive Fluorescent Nanoparticles for Multimodal Imaging and Treatment of Cancers [0.03%]
用于癌症多模态影像和治疗的温敏型荧光纳米粒子
Nikhil Pandey,Jyothi U Menon,Masaya Takahashi et al.
Nikhil Pandey et al.
Theranostic systems capable of delivering imaging and therapeutic agents at a specific target are the focus of intense research efforts in drug delivery. To overcome non-degradability and toxicity concerns of conventional theranostic system...
Nano-Antagonist Alleviates Inflammation and Allows for MRI of Atherosclerosis [0.03%]
纳米拮抗剂可减轻动脉炎症并用于动脉粥样硬化的MRI检测
Brian Mog,Courteney Asase,Alice Chaplin et al.
Brian Mog et al.
Specific targeting of inflammation remains a challenge in many pathologies, because of the necessary balance between host tolerance and efficacious inflammation resolution. Here, we discovered a short, 4-mer peptide which possesses antagoni...
Theranostic nanoparticles enhance the response of glioblastomas to radiation [0.03%]
诊疗纳米颗粒可增强胶质母细胞瘤的放射反应
Wei Wu,Jessica L Klockow,Suchismita Mohanty et al.
Wei Wu et al.
Despite considerable progress with our understanding of glioblastoma multiforme (GBM) and the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with tumor recurrence due to radioresistance being a major c...
Microbubble-enhanced ultrasound for the antivascular treatment and monitoring of hepatocellular carcinoma [0.03%]
用于抗血管生成治疗和监测肝细胞癌的微泡增强超声技术
Julia C D&#x;Souza,Laith R Sultan,Stephen J Hunt et al.
Julia C D&#x;Souza et al.
Background and Objective: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, and its current management relies heavily on locoregional therapy for curative therapy, bridge to transplant, and palliative therapy. Loco...
Enhanced blood-brain-barrier penetrability and tumor-targeting efficiency by peptide-functionalized poly(amidoamine) dendrimer for the therapy of gliomas [0.03%]
用于胶质瘤治疗的肽修饰聚酰胺胺树状大分子，提高其血脑屏障渗透能力及肿瘤靶向效率
Changliang Liu,Zijian Zhao,Houqian Gao et al.
Changliang Liu et al.
Glioblastoma is one of the most common primary tumor types of central nervous system (CNS) with high malignance and lethality. Although many treatment options are currently available, the therapy of brain cancers remains challenging because...