Macrophage imaging and subset analysis using single-cell RNA sequencing [0.03%]
利用单细胞RNA测序进行巨噬细胞成像和亚群分析
Sean Arlauckas,Nuri Oh,Ran Li et al.
Sean Arlauckas et al.
Macrophages have been associated with drug response and resistance in diverse settings, thus raising the possibility of using macrophage imaging as a companion diagnostic to inform personalized patient treatment strategies. Nanoparticle-bas...
Imaging of cell-based therapy using 89Zr-oxine ex vivo cell labeling for positron emission tomography [0.03%]
利用89Zr-花青染料外标法的细胞治疗影像学PET研究
Yutaka Kurebayashi,Peter L Choyke,Noriko Sato
Yutaka Kurebayashi
With the rapid development of anti-cancer cell-based therapies, such as adoptive T cell therapies using tumor-infiltrating T cells, T cell receptor transduced T cells, and chimeric antigen receptor T cells, there has been a growing interest...
Neural precursors cells expanded in a 3D micro-engineered niche present enhanced therapeutic efficacy in vivo [0.03%]
三维微工程生态位中扩增的神经前体细胞具有更强的体内治疗效果
Stephana Carelli,Toniella Giallongo,Federica Rey et al.
Stephana Carelli et al.
Rationale: Stem Cells (SCs) show a great potential in therapeutics for restoring and regenerating native tissues. The clinical translation of SCs therapies is currently hindered by the inability to expand SCs in vitro in large therapeutic d...
Cancer-derived EVs show tropism for tissues at early stage of neoplastic transformation [0.03%]
癌症衍生的外泌体表现出对新生物转化早期组织的趋向性
Mariangela Garofalo,Alessandro Villa,Electra Brunialti et al.
Mariangela Garofalo et al.
From the past decade, extracellular vesicles (EVs) have attracted considerable attention as tools for the selective delivery of anti-neoplastic drugs to cancer tissues. Compared to other nanoparticles, EVs display interesting unique feature...
The effect of ultrasound pulse length on microbubble cavitation induced antibody accumulation and distribution in a mouse model of breast cancer [0.03%]
超声脉冲长度对微泡空化诱导抗体在乳腺癌小鼠模型中积聚和分布的影响
Marie Amate,Joseph Goldgewicht,Balasubramanian Sellamuthu et al.
Marie Amate et al.
In solid tumors, the limited diffusion of therapeutic molecules in the perivascular space is a known limitation impacting treatment efficacy. Ultrasound Targeted Microbubble Cavitation (UTMC) has been shown to increase vascular permeability...
Local delivery of insulin/IGF-1 for bone regeneration: carriers, strategies, and effects [0.03%]
用于骨再生的局部胰岛素/IGF-1递送：载体、策略和影响
Xiaoxuan Zhang,Helin Xing,Feng Qi et al.
Xiaoxuan Zhang et al.
Bone defects caused by trauma, tumor resection, congenital malformation and infection are still a major challenge for clinicians. Biomimetic bone materials have attracted more and more attention in science and industry. Insulin and insulin-...
Electrostatic reaction for the detection of circulating tumor cells as a potential diagnostic biomarker for metastasis in solid tumor [0.03%]
用于检测循环肿瘤细胞的静电反应作为实体瘤转移的潜在诊断生物标志物
Zhiming Li,Xingping Liu,Weidong Zhang et al.
Zhiming Li et al.
The detection of circulating tumor cells (CTCs) from blood samples is important to predict metastatic spread of cancer cells. However, effective quantification and identification of CTCs in solid tumors remain a challenge. Aerobic glycolysi...
Multiplex detection of ctDNA mutations in plasma of colorectal cancer patients by PCR/SERS assay [0.03%]
PCR/SERS测定法在结直肠癌患者血浆中多重检测ctDNA突变
Nana Lyu,Vinoth Kumar Rajendran,Russell J Diefenbach et al.
Nana Lyu et al.
Molecular diagnostic testing of KRAS and BRAF mutations has become critical in the management of colorectal cancer (CRC) patients. Some progress has been made in liquid biopsy detection of mutations in circulating tumor DNA (ctDNA), which i...
Histologic evaluation of activation of acute inflammatory response in a mouse model following ultrasound-mediated blood-brain barrier using different acoustic pressures and microbubble doses [0.03%]
不同声强和微泡剂量介导的超声开放血脑屏障激活急性炎症反应的组织学评价
Aurea Pascal,Ningrui Li,Kendra J Lechtenberg et al.
Aurea Pascal et al.
Rationale: Localized blood-brain barrier (BBB) opening can be achieved with minimal to no tissue damage by applying pulsed focused ultrasound alongside a low microbubble (MB) dose. However, relatively little is known regarding how varying t...
A Gold Nanoparticle Bouquet held on plasma membrane: An ultrasensitive dark-field imaging approach for Cancer Cell Analysis [0.03%]
一种超灵敏暗场成像的癌症细胞分析方法及应用
Yue Cao,Jie Wang,Qiao-Yan Jiang et al.
Yue Cao et al.
Rational: p53 is suppressing tumor protein correlated with the cell cycle factors and apoptosis. Here, a gold nanoparticle bouquet is designed for an ultrasensitive dark-field imaging approach for cancer cell analysis. Methods: AuNP60/APBA ...