Surface enhanced deep Raman detection of cancer tumour through 71 mm of heterogeneous tissue [0.03%]
一种能穿透71毫米异质性组织的肿瘤深部拉曼检测技术
Priyanka Dey,Alexandra Vaideanu,Sara Mosca et al.
Priyanka Dey et al.
Detection of solid tumours through tissue- from depths relevant to humans- has been a significant challenge for biomedical Raman spectroscopy. The combined use of surface enhanced Raman scattering (SERS) imaging agents with deep Raman spect...
EK-16A liposomes enhance HIV replication in ACH2 or J-Lat 10.6 cell engrafted NSG mice [0.03%]
EK-16A脂质体增强ACH2或J-Lat 10. 6细胞移植NSG小鼠中HIV的复制
Panpan Lu,Jinlong Yang,Xinyi Yang et al.
Panpan Lu et al.
Background: Numbers of HIV latency reversal agents (LRAs) have been tested in clinical trials, but with limited effect. EK-16A is an ingenol derivative that isolated from Euphorbia kansui. Our prior studies have suggested that it could reac...
A 2D nanotheranostic platform based on graphene oxide and phase-change materials for bimodal CT/MR imaging, NIR-activated drug release, and synergistic thermo-chemotherapy [0.03%]
一种基于石墨烯和相变材料的二维纳米诊疗平台用于双模CT/MR成像、NIR激活药物释放及协同热化疗
Mehri Mirrahimi,Zahra Alamzadeh,Jaber Beik et al.
Mehri Mirrahimi et al.
Recent years have seen considerable progress in the development of nanomedicine by the advent of 2D nanomaterials serving as ideal platforms to integrate multiple theranostic functions. We synthesized multifunctional stimuli-responsive 2D-b...
Lanthanide-based β-Tricalcium Phosphate Upconversion Nanoparticles as an Effective Theranostic Nonviral Vectors for Image-Guided Gene Therapy [0.03%]
基于镧系元素的β-三钙磷酸盐上转换纳米颗粒作为有效的光控基因治疗非病毒载体用于影像引导的基因治疗研究
Flavia Rodrigues Oliveira Silva,Nelson Batista Lima,Maria Helena Bellini et al.
Flavia Rodrigues Oliveira Silva et al.
Lanthanide-based beta-tricalcium phosphate (β-TCP) upconversion nanoparticles are exploited as a non-viral vector for imaging guided-gene therapy by virtue of their unique optical properties and multi-modality imaging ability, high transfe...
Taha Rakhshandehroo,Bryan Ronain Smith,Hannah J Glockner et al.
Taha Rakhshandehroo et al.
Novel targeted therapies are rapidly emerging for the treatment of cancer. With the advent of new immune targeting agents, understanding the changes in the tumor microenvironment (TME) is critical. Given the complexity and several cellular ...
Intracellular vesicle entrapment of nanobubble ultrasound contrast agents targeted to PSMA promotes prolonged enhancement and stability in vivo and in vitro [0.03%]
针对PSMA的纳米气泡超声造影剂的细胞内囊泡捕获可促进体内和体外长时间增强和稳定化
Reshani H Perera,Eric Abenojar,Pinunta Nittayacharn et al.
Reshani H Perera et al.
Gas-core nanoscale bubbles (or nanobubbles) have gained significant recent attention as promising contrast agents for cancer molecular imaging using medical ultrasound. Previous work has shown that active targeting of nanobubbles to tumor b...
Visualizing surface marker expression and intratumoral heterogeneity with SERRS-NPs imaging [0.03%]
具有SERRS-NPs成像的表面标记表达和瘤内异质性可视化
Lara K Rotter,Naxhije Berisha,Hsiao-Ting Hsu et al.
Lara K Rotter et al.
Cell surface marker expression in tumors dictates the selection of therapeutics, therapy response, and survival. However, biopsies are invasive, sample only a small area of the tumor landscape and may miss significant areas of heterogeneous...
Anti-PD-L1 F(ab) Conjugated PEG-PLGA Nanoparticle Enhances Immune Checkpoint Therapy [0.03%]
抗PD-L1的F（ab）'PEG-PLGA纳米粒子增强免疫检查点疗法
Christina K Lee,Danielle F Atibalentja,Lilian E Yao et al.
Christina K Lee et al.
Background: Immune checkpoint therapies are effective in the treatment of a subset of patients in many different cancers. Immunotherapy offers limited efficacy in part because of rapid drug clearance and off-target associated toxicity. PEG-...
Mild hyperthermia accelerates doxorubicin clearance from tumour-extravasated temperature-sensitive liposomes [0.03%]
轻度发热可加速柔红霉素从肿瘤外渗的温敏脂质体中清除
Wafa&#x; T Al-Jamal,Kostas Kostarelos
Wafa&#x; T Al-Jamal
Mild hyperthermia (HT) (40-43 °C) has been combined with temperature-sensitive liposomes (TSL), offering on-demand drug release for increased drug bioavailability and reduced systemic toxicity. Different HT regimens have been applied to tr...
Lipid nitroalkene nanoparticles for the focal treatment of ischemia reperfusion [0.03%]
用于缺血再灌注局部治疗的脂质亚硝基烯纳米颗粒
Gary Z Yu,Thiruganesh Ramasamy,Marco Fazzari et al.
Gary Z Yu et al.
Rationale: The treatment of microvascular obstruction (MVO) using ultrasound-targeted LNP cavitation (UTC) therapy mechanically relieves the physical obstruction in the microcirculation but does not specifically target the associated inflam...