Can we identify which patients are likely to have septic arthritis with borderline synovial fluid cell counts? [0.03%]
我们能否识别出滑膜细胞数量处于临界值患者的脓毒性关节炎？
Boshen Liu,Michael Raffetto,Eric J Abbenhaus et al.
Boshen Liu et al.
Objective: Septic arthritis (SA) is a clinical emergency that requires prompt diagnosis and surgical treatment to minimize morbidity and mortality. A synovial fluid cell count (SFCC) greater than 50 000 mm-3 has been a threshold used to dia...
CarboCell G/C provides sustained high local bone antibiotic levels with minimal systemic exposure, supporting its therapeutic potential in orthopedic infection management [0.03%]
CarboCell G/C能够提供较高的局部骨抗生素浓度且极少产生全身暴露效应，具有潜在的治疗价值可应用于骨骼感染管理中
Nicole Lind Henriksen,Andrea René Jørgensen,Michal Poborsky et al.
Nicole Lind Henriksen et al.
Introduction: Achieving sustained local antibiotic concentrations is critical for managing orthopedic infections. This proof-of-concept study evaluated release kinetics, local/systemic concentrations, and histological responses to CarboCell...
Adverse events and tolerability of long-term suppressive antibiotic therapy for periprosthetic joint infection: a prospective cohort study [0.03%]
长期抗生素抑制治疗关节置换术后感染的不良事件及耐受性：前瞻性队列研究
Pia Reinecke,Svetlana Karbysheva,Stavros Goumenos et al.
Pia Reinecke et al.
Background: Long-term suppressive antibiotic therapy (SAT) is a management strategy for periprosthetic joint infection (PJI) when eradication is unattainable. However, SAT is often associated with adverse events (AEs) that may impact qualit...
Blood gas analyzers enable reliable measurement of synovial pH, lactate, and glucose in native and periprosthetic joint infection: an analytical agreement study [0.03%]
血气分析仪能够可靠地测量原发性和人工关节感染滑膜液的pH值、乳酸和葡萄糖：一项分析一致性研究
Dirk Müller,Igor Lazic,Benjamin Schloßmacher et al.
Dirk Müller et al.
Background: Synovial pH, lactate, and glucose are established biomarkers for septic arthritis in native joints and have emerging utility in periprosthetic joint infection (PJI). In routine care, these biomarkers are commonly analyzed in cen...
Rifampin resistance and multidrug resistance or extensive drug resistance (MDR/XDR) predict failure in monomicrobial Staphylococcus epidermidis periprosthetic joint infection (PJI) - a 15-year single-center cohort study [0.03%]
耐利福平和多重耐药或广泛耐药（MDR / XDR）单微生物表皮葡萄球菌假体周围关节感染（PJI）失败的预测因子-一项15年的单一中心队列研究
Álvaro Auñon,Santiago Gabardo,Carmen Álvaro et al.
Álvaro Auñon et al.
Introduction: Staphylococcus epidermidis is a leading coagulase-negative pathogen in periprosthetic joint infection (PJI), but the outcome impact of key resistance phenotypes is unclear. Methods: We retrospectively studied consecutive monom...
Diagnostic accuracy of alpha-defensin ELISA and lateral flow assays for periprosthetic joint infection: a systematic review and meta-analysis [0.03%]
α-防御素酶联免疫吸附测定和侧向流动分析诊断假体周围关节感染的准确性：系统评价和meta分析
Benjamin R Paul,David G Deckey,Alex Soriano et al.
Benjamin R Paul et al.
Background: Alpha-defensin (AD) is a synovial biomarker that can be used in the diagnosis of periprosthetic joint infection (PJI). Two testing modalities are available: the laboratory-based enzyme-linked immunosorbent assay (ELISA) and the ...
Empirical antibiotic therapy in acute orthopaedic infections: differences in antimicrobial susceptibility across anatomical sites [0.03%]
急性骨科感染的经验性抗生素治疗：解剖部位不同抗菌素敏感性的差异
Yoni Lodewijk-van den Brink,Jon H M Goosen,Denise S C Telgt et al.
Yoni Lodewijk-van den Brink et al.
Background: The selection of empirical antibiotic therapy for early postoperative orthopaedic infections is challenging because pathogen distribution, antimicrobial resistance, and microbiology vary locally and by anatomical site. Dutch nat...
Twenty common errors in the prevention, diagnosis, and treatment of fracture-related infection (FRI) [0.03%]
骨折相关感染（FRI）预防、诊断和治疗的二十项常见错误
Goran Georgievski,Nike Walter,Ronald Man Yeung Wong et al.
Goran Georgievski et al.
Fracture-related infections are among the most serious complications following osteosynthesis. They jeopardize fracture healing, prolong treatment duration, and can lead to loss of function or even amputation. Despite established standards,...
Is there a role for lavage aspiration after a dry tap in the work-up for potential periprosthetic joint infection? A systematic review [0.03%]
干抽后冲洗吸引在潜在的人工关节感染诊断中的作用如何？一项系统综述
Sander Bruyninckx,Stijn Ghijselings,Melissa Depypere et al.
Sander Bruyninckx et al.
Aim: Lavage aspiration following a dry tap remains a debated technique in the work-up for periprosthetic joint infection (PJI) of the hip and knee. This systematic review critically appraises the available evidence, with a particular focus ...
Diagnostic parameters in native joint septic arthritis and development of a new evaluation score [0.03%]
原发性关节化脓性关节炎的诊断参数及新的评价体系构建
Lorenz Huber,Hasan S Aguicenoglu,Susanne Baertl et al.
Lorenz Huber et al.
Introduction: Septic arthritis (SA) is an orthopaedic emergency; delayed treatment endangers joint function and survival. Unlike periprosthetic infections, diagnostic criteria for native joints are poorly standardized. This study aimed to (...