Nasopharyngeal microbiota profiles and lytA-PCR status in adult pneumococcal pneumonia: distinct microbial communities and diagnostic implications [0.03%]
成人肺炎链球菌肺炎的鼻咽微生物群特征和lytA-PCR状态：不同的微生物群落及诊断意义
Beatriz Dietl,Desirée Henares,Miguel Blanco-Fuertes et al.
Beatriz Dietl et al.
Background: Streptococcus pneumoniae is a leading cause of community-acquired pneumonia (CAP) in adults, yet microbiological diagnosis remains challenging. Quantitative lytA-PCR on nasopharyngeal samples has improved diag...
Pneumococcal pneumonia in adults - re-emergence of vaccine serotypes: a prospective multicenter cohort study in Germany, 2020-2023 [0.03%]
德国成人肺炎链球菌肺炎的再发：2020-2023年前瞻性多中心队列研究
Christina Bahrs,Norman Rose,Grit Barten-Neiner et al.
Christina Bahrs et al.
The main burden of non-invasive pneumococcal diseases in adults is largely due to community-acquired pneumonia (CAP). This study aimed to investigate the distribution and dynamics of pneumococcal vaccine serotypes and to determine the propo...
Development and internal validation of a Viremia-Integrated Risk Assessment (VIRA score) for predicting mortality at diagnosis of COVID-19 pneumonia [0.03%]
用于预测COVID-19肺炎诊断时死亡率的血液病毒水平综合风险评估(VIRA评分)模型的研制与内部验证
Sonsoles Salto-Alejandre,Cristina Rodríguez-Urbistondo,Javier Martin-Escolano et al.
Sonsoles Salto-Alejandre et al.
Background: CURB-65 score usefulness has been assessed in COVID-19 pneumonia, but not in cohorts including immunocompromised patients. SARS-CoV-2 RNAemia is associated with mortality and unfavorable clinical outcomes in C...
Antibiotic non-susceptibility associated serotypes of invasive pneumococcal disease - a nationwide population study from Switzerland, 2012-2022 [0.03%]
2012-2022年瑞士全国人口研究中与侵袭性肺炎球菌病抗药性相关的血清型分布研究
Nicolaj Just,Carlo Casanova,Florent Baty et al.
Nicolaj Just et al.
Introduction: It has been reported that the introduction of thirteen-valent pneumococcal conjugate vaccine (PCV13) had an influence on antibiotic resistance rates of invasive pneumococcal disease (IPD). Recent data about ...
Corticosteroids in immunocompromised ICU patients with pneumonia: risks, evidence, and clinical practice [0.03%]
免疫抑制ICU肺炎患者的皮质类固醇的风险、证据和临床实践
Jeison Andrés Morales-Olivera,Paula O Narvaez-Ramirez,Ingrid G Bustos et al.
Jeison Andrés Morales-Olivera et al.
Adjunctive corticosteroids are increasingly used in Severe Community-Acquired Pneumonia (sCAP) requiring admission to the intensive care unit (ICU), based on evidence derived largely from immunocompetent populations. Immunocompromised hosts...
A multicentre case-control study about effectiveness of pneumococcal vaccination against pneumonia hospitalization in at-risk adults [0.03%]
一项多中心病例对照研究：肺炎球菌疫苗针对高危成人住院肺炎的效力研究
María Liébana,Diana Toledo,Núria Soldevila et al.
María Liébana et al.
Background: Community-acquired pneumonia (CAP) is a leading cause of morbidity in adults with chronic conditions. Although pneumococcal vaccine effectiveness (VE) has been demonstrated in older adults, evidence is scant r...
Mariano Esperatti,Matías Olmos,Nora Fuentes
Mariano Esperatti
Acute respiratory distress syndrome (ARDS) remains a high‑mortality condition despite major advances in ventilatory and supportive care. Because lung injury is driven by uncontrolled inflammation and disruption of the alveolar–capillary b...
Pneumonia as a predictor of diabetes mellitus and coronary heart disease: a national cohort study [0.03%]
肺炎作为预测糖尿病和冠心病的指标：一项全国队列研究
Filip Jansåker,Xinjun Li,Kristina Sundquist et al.
Filip Jansåker et al.
Background: Pneumonia is a common infection that leads to frequent hospitalizations and primary healthcare visits. Previous smaller studies have indicated high prevalence of undiagnosed diabetes mellitus (DM) and increase...
The heterogeneous treatment effect of adjuvant therapy with corticosteroids in patients with Community-Acquired Pneumonia: a review [0.03%]
糖皮质激素作为社区获得性肺炎患者二线治疗的异质性疗效分析：一篇综述
Jim M Smit,A Torres,P A van der Zee et al.
Jim M Smit et al.
Randomized Controlled Trials (RCTs) assessing adjuvant corticosteroids for hospitalized Community-Acquired Pneumonia (CAP) show mixed results, suggesting Heterogeneity of Treatment Effect (HTE). Current guidelines conflict: some restrict us...
Nicole Cossrow,Salini Mohanty,Kelly D Johnson et al.
Nicole Cossrow et al.
Background: There are significant racial and environmental disparities in the burden of pneumococcal disease. Understanding the role of social determinants of health (SDoH) on pneumococcal disease can help health authorit...