Opioid Therapy Discontinuation in General Practice: Associations with Adjunct Therapies and Somatoform Pain Disorders [0.03%]
阿片类药物治疗在综合医疗机构中的停药与辅助治疗和躯体形式疼痛障碍的关系
Sabrina Brinkmöller,Regina Poß-Doering,Cornelia Straßner et al.
Sabrina Brinkmöller et al.
Background: Chronic non-cancer pain is a common reason for consultation in primary care. Although opioid therapy may be considered a treatment option for selected patients, guideline-recommended discontinuation can be cha...
Real-World Effectiveness and Safety of Dotinurad in Chinese Patients with Gout: A Comparative Analysis [0.03%]
托替溴铵在中国痛风患者中的有效性及安全性：对比分析
Guanqun Yi,Xuechan Huang,Yukai Huang et al.
Guanqun Yi et al.
Background: Dotinurad, a novel selective uric acid (UA) reabsorption inhibitor, exerts its hypouricemic effect through the selective inhibition of urate transporter 1 (URAT1). The present study aimed to investigate the sh...
Residual Burden in Adalimumab-Treated Patients with Hidradenitis Suppurativa: An Observational Cohort Study Based on Insurance Claims in the USA [0.03%]
美国基于保险理赔的观察队列研究中的阿达木单抗治疗失败的汗腺炎患者残留负担研究
Maria A Aleshin,Tanja Tran,Ingrid Pansar et al.
Maria A Aleshin et al.
Introduction: Hidradenitis suppurativa (HS), a chronic, inflammatory skin disease, causes significant morbidity. Until 2023, adalimumab was the only US-approved biologic for patients with moderate to severe HS. ...
Calcitonin Gene-Related Peptide Monoclonal Antibody Utilization and Treatment Gaps in People with Migraine in Japan: Results from the OVERCOME (Japan) 2nd Study [0.03%]
日本偏头痛患者的降钙素基因相关肽单克隆抗体使用情况及治疗缺口：来自OVERCOME（日本）第2项研究的结果
Yoshiki Hanaoka,Tsubasa Takizawa,Ryotaro Ishii et al.
Yoshiki Hanaoka et al.
Background: Calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) are an effective preventive treatment for migraine. However, their population-level utilization patterns and treatment gaps are underreported i...
Feasibility of Reconstructing Survival Outcomes from Unstructured Electronic Medical Records under Japan's Next-Generation Medical Infrastructure Act: A Historical Cohort Study of Atezolizumab in Non-small Cell Lung Cancer [0.03%]
在日本下一代医疗基础设施法案下，从非结构化电子健康记录中重建无小细胞肺癌患者阿特珠单抗治疗生存结果的可行性：历史性队列研究
Masahiko Nakatsui,Yosuke Nishida,Suguru Nozue et al.
Masahiko Nakatsui et al.
Background and objective: As the use of real-world evidence (RWE) expands, evaluating whether Japanese real-world data (RWD) can reproduce clinical trial findings is crucial. This study aimed to determine whether pseudony...
Treatment Selection Patterns and Associated Outcomes for Biguanides and SGLT2 Inhibitors in Type 2 Diabetes: A Retrospective Database Study in Japan [0.03%]
二甲双胍和SGLT2抑制剂治疗选择模式及相应的临床结局：日本2型糖尿病患者的数据库回溯分析
Ryo Mishima,Daisuke Koide
Ryo Mishima
Background: Type 2 diabetes mellitus has multiple treatment options and high healthcare costs. In Japan, DPP-4 inhibitors have been widely used, but since 2022 the pharmacotherapy algorithm has shifted: DPP-4 inhibitors a...
Pre-existing Comorbidities as Potential Risk Modifiers for New-Onset Myocarditis and Pericarditis following mRNA COVID-19 Vaccination in Males Aged 18-30 in the United States: A Disproportionality Analysis using VAERS Spontaneous Reporting Data [0.03%]
美国18至30岁男性在接种mRNA新冠疫苗后新发心肌炎和心包炎的潜在危险因素：来自VAERS自发报告数据的比例分析研究
Mohammed Salah Salem,Yola Moride,Bernard Bégaud
Mohammed Salah Salem
Background: Rare cases of myocarditis and pericarditis following mRNA coronavirus disease-19 (COVID-19) vaccination have been reported, primarily among males under 30 years of age. Although the underlying mechanisms remai...
Complications and Occurrence of Exacerbations in Patients with Myasthenia Gravis Treated with Oral Corticosteroids [0.03%]
口服皮质类固醇治疗重症肌无力患者的并发症和病情加重发生率
Zhiwen Liu,Louis Jackson,Jacqueline Pesa et al.
Zhiwen Liu et al.
Background: Myasthenia gravis is a rare disease characterized by autoantibody-driven impairment of neuromuscular junction activity. Standard-of-care therapy includes oral corticosteroids (OCS), despite associated complica...
Three-Year Interim Results from a Post-Marketing Surveillance Study of Patients with Migraine Treated with Fremanezumab in South Korea [0.03%]
韩国偏头痛患者注射呋喃唑坦的上市后监测研究三年中期结果
Dayoung Seo,Manho Kim,Mi Ji Lee et al.
Dayoung Seo et al.
Background: There is limited real-world evidence on the safety and effectiveness of fremanezumab in South Korea. Objective: We aimed to...
Assessment of Potential Drug-Drug Interactions and Associated Factors Among Pulmonary Inpatients in a Tertiary Care Hospital: A Cross-Sectional Study [0.03%]
三级医疗机构中肺科住院患者的潜在药物相互作用及影响因素的横断面研究评估
Nim Bahadur Dangi,Hari Prasad Sapkota,Gobinda Kandel et al.
Nim Bahadur Dangi et al.
Background: Potential Drug-drug interactions (pDDIs) are a significant cause of adverse drug events and can compromise treatment outcomes, especially in hospitalized patients who are prescribed multiple medications. Pulmo...