Designing Biopolymer Microthreads for Tissue Engineering and Regenerative Medicine [0.03%]
用于组织工程和再生医学的生物聚合物微丝的设计
Megan P O&#x;Brien,Meagan E Carnes,Raymond L Page et al.
Megan P O&#x;Brien et al.
Native tissue structures possess elaborate extracellular matrix (ECM) architectures that inspire the design of fibrous structures in the field of regenerative medicine. We review the literature with respect to the successes and failures, as...
MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis [0.03%]
微小核糖核酸在正常和恶性血液发生中的造血干细胞调控作用
Christine Roden,Jun Lu
Christine Roden
Studies on hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) have helped to establish the paradigms of normal and cancer stem cell concepts. For both HSCs and LSCs, specific gene expression programs endowed by their epigenome f...
Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development [0.03%]
脂肪组织和间充质干细胞：前沿研究与Lipogems技术的发展
Carlo Tremolada,Valeria Colombo,Carlo Ventura
Carlo Tremolada
In the past few years, interest in adipose tissue as an ideal source of mesenchymal stem cells (MSCs) has increased. These cells are multipotent and may differentiate in vitro into several cellular lineages, such as adipocytes, chondrocytes...
Adult Versus Pluripotent Stem Cell-Derived Mesenchymal Stem Cells: The Need for More Precise Nomenclature [0.03%]
成人与多能干细胞来源的间充质干细胞：更精确术语的需求
Michael D West,Igor Nasonkin,David Larocca et al.
Michael D West et al.
The complexity of human pluripotent stem cell (hPSC) fate represents both opportunity and challenge. In theory, all somatic cell types can be differentiated from hPSCs, opening the door to many opportunities in transplant medicine. However,...
Dafne Campigli Di Giammartino,Effie Apostolou
Dafne Campigli Di Giammartino
The revolutionary discovery that somatic cells can be reprogrammed by a defined set transcription factors to induced pluripotent stem cells (iPSCs) changed dramatically the way we perceive cell fate determination. Importantly, iPSCs, simila...
Human Stem Cell-Derived Astrocytes: Specification and Relevance for Neurological Disorders [0.03%]
人诱导多能干细胞来源星形胶质细胞的定向分化及其在神经系统疾病中的作用
Giulia Tyzack,Andras Lakatos,Rickie Patani
Giulia Tyzack
Astrocytes abound in the human central nervous system (CNS) and play a multitude of indispensable roles in neuronal homeostasis and regulation of synaptic plasticity. While traditionally considered to be merely ancillary supportive cells, t...
Maqsood Ahmed,Charles Ffrench-Constant
Maqsood Ahmed
Stem cells hold great promise in treating many diseases either through promoting endogenous cell repair or through direct cell transplants. In order to maximize their potential, understanding the fundamental signals and mechanisms that regu...
Asako Tajima,Isha Pradhan,Massimo Trucco et al.
Asako Tajima et al.
The thymus is the primary site for the generation of a diverse repertoire of T-cells that are essential to the efficient function of adaptive immunity. Numerous factors varying from aging, chemotherapy, radiation exposure, virus infection a...
A Broad Overview and Review of CRISPR-Cas Technology and Stem Cells [0.03%]
关于CRISPR-Cas技术及干细胞的概览与评论
Simon N Waddington,Riccardo Privolizzi,Rajvinder Karda et al.
Simon N Waddington et al.
The pinnacle of four decades of research, induced pluripotent stem cells (iPSCs), and genome editing with the advent of clustered, regularly interspaced, short palindromic repeats (CRISPR) now promise to take drug development and regenerati...
Design Principles for Engineering of Tissues from Human Pluripotent Stem Cells [0.03%]
基于人多能干细胞的组织工程设计原则
Oriane B Matthys,Tracy A Hookway,Todd C McDevitt
Oriane B Matthys
Recent advances in human pluripotent stem cell (hPSC) technologies have enabled the engineering of human tissue constructs for developmental studies, disease modeling, and drug screening platforms. In vitro tissue formation can be generally...