Genomic Instability and Clonal Hematopoiesis in the Deep-Space Environment: The Role of Sex-Chromosome Asymmetry and High-LET Radiation [0.03%]
深空环境中的基因组不稳定性与克隆型造血作用：性染色体不对称性和高线能量传递辐射的作用
Roksana Zakharyan,Ani Stepanyan,Arpine Minasyan et al.
Roksana Zakharyan et al.
Purpose of review: This paper examines how deep-space conditions in the Artemis program, including radiation, microgravity, and other stressors affect genomic stability in blood-forming cells, with a focus on clonal hemat...
Induced Pluripotent Stem Cell-Derived Red Blood Cells, Megakaryocytes, and Platelets: Progress and Challenges [0.03%]
诱导多能干细胞来源的红细胞、巨核细胞和血小板：进展与挑战
Hyun Hyung An,Mortimer Poncz,Stella T Chou
Hyun Hyung An
Purpose of review: Human induced pluripotent stem cells (iPSCs) represent an attractive source to generate in vitro-derived red blood cells, megakaryocytes, and platelets for transfusion support. We review the progress ma...
The technical and ethical framework of fetal therapy: past and current advances [0.03%]
胎儿治疗的技术和伦理框架：过去与现在的进展
Anna Y Lynn,Peter M Glazer,W Mark Saltzman et al.
Anna Y Lynn et al.
Purpose of review: Fetal therapy, a burgeoning field that encompasses prenatal surgical and medical interventions for congenital diseases, enables minimally invasive strategies of pharmacologic drug treatment before birth...
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation [0.03%]
胚胎干细胞多能性和分化中RNA对糖酵解的调控作用
Wei Fan,Xiaoling Li
Wei Fan
Purpose of review: The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a core part of cellular metabolism, glycolysis provides energy and biomolecules impor...
Transcription factors and splice factors - interconnected regulators of stem cell differentiation [0.03%]
转录因子和剪接因子在干细胞分化中的串扰机制
Madison M Mehlferber,Muge Kuyumcu-Martinez,Clint L Miller et al.
Madison M Mehlferber et al.
Purpose of review: The underlying molecular mechanisms that direct stem cell differentiation into fully functional, mature cells remain an area of ongoing investigation. Cell state is the product of the combinatorial effe...
Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It [0.03%]
干细胞生物学及其它领域中的定量建模：如何最好地利用它
Philip Greulich
Philip Greulich
Purpose of review: This article gives a broad overview of quantitative modelling approaches in biology and provides guidance on how to employ them to boost stem cell research, by helping to answer biological questions and...
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling [0.03%]
人干细胞在眼科中的应用：诊断图像分析和计算建模的最新进展
L E Wadkin,I Makarenko,N G Parker et al.
L E Wadkin et al.
Purpose of review: To explore the advances and future research directions in image analysis and computational modelling of human stem cells (hSCs) for ophthalmological applications. ...
Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility [0.03%]
基于细胞的再生医学 reproducibility研究原则的应用
Alicia D Henn,Kunal Mitra,Joshua Hunsberger et al.
Alicia D Henn et al.
Purpose of review: Cell and tissue products do not just reflect their present conditions; they are the culmination of all they have encountered over time. Currently, routine cell culture practices subject cell and tissue ...
Abhishek K Singh,Jose A Cancelas
Abhishek K Singh
Purpose of review: The well-established crosstalk between hematopoietic stem cells (HSC) and bone marrow (BM) microenvironment is critical for the homeostasis and hematopoietic regeneration in response to blood formation ...
Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE) [0.03%]
年龄、性别和基因多态性对造血急性辐射综合征(H-ARS)和放射后远期效应(DEARE)小鼠模型的影响
Christie M Orschell,Tong Wu,Andrea M Patterson
Christie M Orschell
Purpose of review: Malicious or accidental radiation exposure increases risk for the hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of acute radiation exposure (DEARE). Radiation medical countermea...