Genome Editing and Muscle Stem Cells as a Therapeutic Tool for Muscular Dystrophies [0.03%]
基因组编辑和肌肉干细胞作为治疗肌营养不良的手段
Veronica Pini,Jennifer E Morgan,Francesco Muntoni et al.
Veronica Pini et al.
Purpose of review: Muscular dystrophies are a group of severe degenerative disorders characterized by muscle fiber degeneration and death. Therapies designed to restore muscle homeostasis and to replace dying fibers are b...
Juliette M K M Delhove,Waseem Qasim
Juliette M K M Delhove
Purpose of review: Alternative approaches to conventional drug-based cancer treatments have seen T cell therapies deployed more widely over the last decade. This is largely due to their ability to target and kill specific...
Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration [0.03%]
利用人多能干细胞和基因编辑治疗视网膜变性潜在能力的研究
Patrick Ovando-Roche,Anastasios Georgiadis,Alexander J Smith et al.
Patrick Ovando-Roche et al.
Purpose of review: A major cause of visual disorders is dysfunction and/or loss of the light-sensitive cells of the retina, the photoreceptors. To develop better treatments for patients, we need to understand how inherite...
New Bioengineering Breakthroughs and Enabling Tools in Regenerative Medicine [0.03%]
再生医学中的新生物工程突破及赋能工具
Alvaro Mata,Helena S Azevedo,Lorenzo Botto et al.
Alvaro Mata et al.
Purpose of review: In this review, we provide a general overview of recent bioengineering breakthroughs and enabling tools that are transforming the field of regenerative medicine (RM). We focus on five key areas that are...
Deconstructing the Complexity of TGFβ Signaling in Hematopoietic Stem Cells: Quiescence and Beyond [0.03%]
破译骨髓造血干细胞中TGFβ信号的复杂性：静息与活动之间
Ashwini Hinge,Marie-Dominique Filippi
Ashwini Hinge
The hematopoietic system is highly dynamic and must constantly produce new blood cells every day. Mature blood cells all derive from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly quiescent but occasionally divide...
Dheeraj Bhavanasi,Peter S Klein
Dheeraj Bhavanasi
Wnt signaling plays important roles in stem cell self-renewal and differentiation in adults as well as in embryonic development. Mutations that activate canonical Wnt/β-catenin signaling also initiate and maintain several cancer states, in...
Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary [0.03%]
类固醇激素与组织驻留干细胞生理调节的作用——来自果蝇卵巢的启示
Elizabeth T Ables,Daniela Drummond-Barbosa
Elizabeth T Ables
Purpose of review: Stem cells respond to local paracrine signals; more recently, however, systemic hormones have also emerged as key regulators of stem cells. This review explores the role of steroid hormones in stem cell...
Doris A Taylor,Rohan B Parikh,Luiz C Sampaio
Doris A Taylor
Purpose of review: In this review, we focus on the multiple advancements in the field of cardiovascular regenerative medicine and the state-of-the art of building a heart. An organ is comprised of cells, but cells alone d...
Shugo Tohyama,Sho Tanosaki,Shota Someya et al.
Shugo Tohyama et al.
Purpose of review: Pluripotent stem cells (PSCs) have the capacity to differentiate into various types of cells, and are promising cell sources for regenerative therapy and drug screening. However, to realize the clinical...
Alex Sargent,Robert H Miller
Alex Sargent
The utilization of mesenchymal stem cells (also known as mesenchymal stromal cells, or MSCs) as a cell-based therapy for diseases that have ongoing inflammatory damage has become increasingly available. Our understanding of the cell biology...